Expanding Three-Coordinate Gold(I) Anticancer Agent Chemical Space by Charles E. Greif (21728091)

“…We report the synthesis and characterization of 14 complexes of the type (Au(R)[N̂N])⁺, where R = tunable biaryldialkyl phosphine ligands and [N̂N] = bidentate phenanthroline derivatives as anticancer agents. …”

Meltrin β does not affect the expression of EphA4 on the cell surface nor the initial association between ephrin-A5 and EphA4, but decreases accessibility of antibodies that recognize the EphA4 C-terminus. by Norihiro Yumoto (270290)

Subjects:

S5 Fig - by Jordan K. Abbott (8934239)

Inactivation of the <i>WNT5A</i> Alternative Promoter B Is Associated with DNA Methylation and Histone Modification in Osteosarcoma Cell Lines U2OS and SaOS-2 by Himani Vaidya (3179403)

“…In this study, we analyzed expression from two of the major <i>WNT5A</i> promoters, termed promoter A and promoter B, in normal human osteoblasts, SaOS-2 and U2OS osteosarcoma cell lines, and osteosarcoma tumor tissue. …”

Image 5_Deciphering the oncogenic network: how C1QTNF1-AS1 modulates osteosarcoma through miR-34a-5p and glycolytic pathways.tif by Yu Zhang (12946)

“…</p>Discussion<p>Our research emphasizes the critical role of C1QTNF1-AS1 in the pathogenesis of osteosarcoma (OS). We discovered that the downregulation of C1QTNF1-AS1 indirectly upregulates the expression of LDHA and PDK3 by suppressing miR-34a-5p, which functions as a regulator of the Warburg effect. …”

Table 5_Deciphering the oncogenic network: how C1QTNF1-AS1 modulates osteosarcoma through miR-34a-5p and glycolytic pathways.doc by Yu Zhang (12946)

“…</p>Discussion<p>Our research emphasizes the critical role of C1QTNF1-AS1 in the pathogenesis of osteosarcoma (OS). We discovered that the downregulation of C1QTNF1-AS1 indirectly upregulates the expression of LDHA and PDK3 by suppressing miR-34a-5p, which functions as a regulator of the Warburg effect. …”

Inhibition of G9a decreases the tumorigenicity of neuroblastoma cells. by Xiao-Xue Ke (626989)

Dual biomarkers long non-coding RNA GAS5 and microRNA-34a co-expression signature in common solid tumors by Eman A. Toraih (2589844)

“…<div><p>Accumulating evidence indicates that non-coding RNAs including microRNAs (miRs) and long non-coding RNAs (lncRNAs) are aberrantly expressed in cancer, providing promising biomarkers for diagnosis, prognosis and/or therapeutic targets. We aimed in the current work to quantify the expression profile of miR-34a and one of its bioinformatically selected partner lncRNA growth arrest-specific 5 (GAS5) in a sample of Egyptian cancer patients, including three prevalent types of cancer in our region; renal cell carcinoma (RCC), glioblastoma (GB), and hepatocellular carcinoma (HCC) as well as to correlate these expression profiles with the available clinicopathological data in an attempt to clarify their roles in cancer. …”

Optical Effects of <i>S</i>-Oxidation and M^<i>n</i>+ Binding in <i>meso</i>-Thienyl Dipyrrin Systems and of Stepwise Bromination of 4,4-Difluoro-8-(2,5-dibromo-3-thienyl... by Shin Hei Choi (2190841)

“…Treatment of 4,4-difluoro-8-(2,5-dibromo-3-thienyl)-4-bora-3<i>a</i>,4<i>a</i>-diaza-<i>s</i>-indacene with Br₂ gave red-shifted UV−vis absorption band features that grow with increasing dipyrrin bromination. …”

Optical Effects of <i>S</i>-Oxidation and M^<i>n</i>+ Binding in <i>meso</i>-Thienyl Dipyrrin Systems and of Stepwise Bromination of 4,4-Difluoro-8-(2,5-dibromo-3-thienyl... by Shin Hei Choi (2190841)

“…Treatment of 4,4-difluoro-8-(2,5-dibromo-3-thienyl)-4-bora-3<i>a</i>,4<i>a</i>-diaza-<i>s</i>-indacene with Br₂ gave red-shifted UV−vis absorption band features that grow with increasing dipyrrin bromination. …”

Optical Effects of <i>S</i>-Oxidation and M^<i>n</i>+ Binding in <i>meso</i>-Thienyl Dipyrrin Systems and of Stepwise Bromination of 4,4-Difluoro-8-(2,5-dibromo-3-thienyl... by Shin Hei Choi (2190841)

“…Treatment of 4,4-difluoro-8-(2,5-dibromo-3-thienyl)-4-bora-3<i>a</i>,4<i>a</i>-diaza-<i>s</i>-indacene with Br₂ gave red-shifted UV−vis absorption band features that grow with increasing dipyrrin bromination. …”

Optical Effects of <i>S</i>-Oxidation and M^<i>n</i>+ Binding in <i>meso</i>-Thienyl Dipyrrin Systems and of Stepwise Bromination of 4,4-Difluoro-8-(2,5-dibromo-3-thienyl... by Shin Hei Choi (2190841)

“…Treatment of 4,4-difluoro-8-(2,5-dibromo-3-thienyl)-4-bora-3<i>a</i>,4<i>a</i>-diaza-<i>s</i>-indacene with Br₂ gave red-shifted UV−vis absorption band features that grow with increasing dipyrrin bromination. …”

Optical Effects of <i>S</i>-Oxidation and M^<i>n</i>+ Binding in <i>meso</i>-Thienyl Dipyrrin Systems and of Stepwise Bromination of 4,4-Difluoro-8-(2,5-dibromo-3-thienyl... by Shin Hei Choi (2190841)

“…Treatment of 4,4-difluoro-8-(2,5-dibromo-3-thienyl)-4-bora-3<i>a</i>,4<i>a</i>-diaza-<i>s</i>-indacene with Br₂ gave red-shifted UV−vis absorption band features that grow with increasing dipyrrin bromination. …”

Optical Effects of <i>S</i>-Oxidation and M^<i>n</i>+ Binding in <i>meso</i>-Thienyl Dipyrrin Systems and of Stepwise Bromination of 4,4-Difluoro-8-(2,5-dibromo-3-thienyl... by Shin Hei Choi (2190841)

“…Treatment of 4,4-difluoro-8-(2,5-dibromo-3-thienyl)-4-bora-3<i>a</i>,4<i>a</i>-diaza-<i>s</i>-indacene with Br₂ gave red-shifted UV−vis absorption band features that grow with increasing dipyrrin bromination. …”

Optical Effects of <i>S</i>-Oxidation and M^<i>n</i>+ Binding in <i>meso</i>-Thienyl Dipyrrin Systems and of Stepwise Bromination of 4,4-Difluoro-8-(2,5-dibromo-3-thienyl... by Shin Hei Choi (2190841)

“…Treatment of 4,4-difluoro-8-(2,5-dibromo-3-thienyl)-4-bora-3<i>a</i>,4<i>a</i>-diaza-<i>s</i>-indacene with Br₂ gave red-shifted UV−vis absorption band features that grow with increasing dipyrrin bromination. …”

Optical Effects of <i>S</i>-Oxidation and M^<i>n</i>+ Binding in <i>meso</i>-Thienyl Dipyrrin Systems and of Stepwise Bromination of 4,4-Difluoro-8-(2,5-dibromo-3-thienyl... by Shin Hei Choi (2190841)

“…Treatment of 4,4-difluoro-8-(2,5-dibromo-3-thienyl)-4-bora-3<i>a</i>,4<i>a</i>-diaza-<i>s</i>-indacene with Br₂ gave red-shifted UV−vis absorption band features that grow with increasing dipyrrin bromination. …”

Infection decreases short chain phospholipids in the intestines of <i>V</i>. <i>cholerae</i>-infected flies. by Audrey S. Vanhove (4090594)

Decreased <i>Pax2</i> expression in <i>p53^−/−</i> embryonic kidneys. by Zubaida Saifudeen (135684)

“…<b>B</b>) In situ hybridization. Decreased expression of <i>Pax2</i> mRNA at E12.5. …”

DataSheet_1_Swine acute diarrhoea syndrome coronavirus (SADS-CoV) Nsp5 antagonizes type I interferon signaling by cleaving DCP1A.pdf by Hai-xin Huang (15774248)

“…SADS-CoV nsp5 targets and cleaves mRNA-decapping enzyme 1a (DCP1A) via its protease activity to inhibit the IRF3 and NF-κB signaling pathways in order to decrease IFN-β and inflammatory cytokine production. …”

Peripheral Erythrocytes Decrease upon Specific Respiratory Challenge with Grass Pollen Allergen in Sensitized Mice and in Human Subjects by Galateja Jordakieva (512458)

“…A significant decrease in circulating erythrocytes and hematocrit levels after airway challenges with grass pollen allergen was also found in grass pollen sensitized human rhinitis subjects (n = 42) at the VCC. …”