K149 of p66α is required for the MBD2 interaction as well as for the MBD2-mediated repression by Marc Brackertz (27647)

“…The bound protein together with the input fractions were analyzed by western blotting using the anti-Gal antibody. () K149R mutant of p66α decreases MBD2-mediated repression. HeLa cells were cotransfected with a 4xUAStk luciferase reporter together with vectors expressing the Gal-DNA binding domain, or Gal-MBD2b and increasing amount of pSG5-p66α or pSG5-p66αK149R. …”

Assessment of transcriptome associated with endothelium activation and blood-brain barrier integrity. by Nana O. Wilson (399957)

“…<p>mRNA expression of angiopoietin-1 (A), angiopoietin-2 (B), ICAM-1 (C), perforin (D), IFN-γ (E), and FasL (F) in whole brain homogenates of control, ARM, ATV, and ATV/ARM-treated <i>P. berghei</i>-infected mice ( = 5 per group). …”

Table_1_Use of Prazosin for Pediatric Post-Traumatic Stress Disorder With Nightmares and/or Sleep Disorder: Case Series of 18 Patients Prospectively Assessed.docx by Vladimir Ferrafiat (9154643)

“…</p>Results<p>Among the 18 patients (10 girls and 8 boys), 13 (72%) had experienced sexual abuse and 5 (28%) family violence. After 1 month of treatment with a mean prazosin dose of 2.16 ( ± 0.6) mg/day, the CGI-S score significantly decreased from 5.3 ( ± 0.9) to 2.9 ( ± 0.7) (improvement of 43%). …”

Maternal iron restriction prior to conception is associated with embryonic iron deficiency, postnatal anemia, and reduced postnatal central nervous system iron levels. by Camelia Mihaila (354659)

“…<p>The <i>ID -2wks</i> and <i>CTL</i> pregnant dams were sacrificed at different time points during gestation (E13, E15, E17, and E19) and embryos were characterized in respect to total iron content by AAS analysis. <b>A</b>. The nutritional <i>ID -2wks</i> regimen generated embryonic ID as early as E15 (Mean ± SEM, * p<0.001). …”

Image2_Deciphering the Active Compounds and Mechanisms of HSBDF for Treating ALI via Integrating Chemical Bioinformatics Analysis.TIF by Yanru Wang (187231)

“…<p>The Huashi Baidu Formula (HSBDF), a key Chinese medical drug, has a remarkable clinical efficacy in treating acute lung injury (ALI), and it has been officially approved by the National Medical Products Administration of China for drug clinical trials. …”

Image1_Deciphering the Active Compounds and Mechanisms of HSBDF for Treating ALI via Integrating Chemical Bioinformatics Analysis.TIF by Yanru Wang (187231)

“…<p>The Huashi Baidu Formula (HSBDF), a key Chinese medical drug, has a remarkable clinical efficacy in treating acute lung injury (ALI), and it has been officially approved by the National Medical Products Administration of China for drug clinical trials. …”

The deamidation of N15 does not depend on deamidation of N71. by Ignacio de la Mora-de la Mora (435666)

“…<p>Native gel electrophoresis of the WT (A) or the N71D mutant (B) after incubation at 1mg/mL in TE buffer at 37°C with 3.5 mM GAP in a temporal course of 5 hours. …”

The morphogenesis and development of VM dopaminergic neurons is disturbed in <i>Dkk1^{<b>−/−</b>}</i> embryos. by Diogo Ribeiro (230483)

“…<p>(A) <i>Dkk1^−/−</i> embryos at E17.5 revealed an absence of most facial and head structures. …”

Representative micrographs of the healing MCL after PBS or IL-1Ra treatment. by Connie S. Chamberlain (440242)

“…In contrast, proliferating cells decrease on day 5 (g–h) after IL-1Ra administration.…”

Plots illustrating different log₁₀ response patterns. by Bertrand Collet (485023)

“…(B) Sustained increase for the immunological molecule Mx. (C) Temporary decrease for the stress molecule hsp90a. Dots (·) represent unchallenged control group values and the dashed lines (---) are the predicted 2.5 and 97.5 percentiles around these. …”

The interplay of gravity and touch responses. by Ilya Loshchilov (3992330)

“…<p>The sensitivity to gravitropic (<i>w</i>_<i>g</i>) and thigmotropic (<i>w</i>_<i>t</i>) signals was set at (a) 0.5 and 0.5, (b) 0.1 and 0.9, and (c) 0.9 and 0.1, respectively. …”

Longitudinal evaluation of cell viability by <i>in vivo</i> BLI. by Annette Tennstaedt (834294)

“…<p>(A) BL images of unlabeled (left) and labeled (right) hNSCs, implanted in the right striatum and longitudinally evaluated from day 0 to day 9 post implantation [¹⁹F labeled cells day 0 (n = 9), day 1 (n = 9), day 2 (n = 8), day 5 (n = 8), day 7 (n = 7), day 9 (n = 5) / unlabeled cells day 0–9 (n = 4)]. …”

Identifying optimal cluster numbers in hierarchical cluster analysis. by Dolores Bernenko (16528426)

“…<p>(a) Reverse-ordered linkage values on a logarithmic scale. …”

First coronal temperature slice was compared against first coronal temperature slices at different sonication parameters. by Avinash Eranki (3842191)

“…Temperature curves obtained while sonicating at 0.5, 2, and 5 Hz PRF. The peak temperatures obtained were 50°C, 72°C, and 95°C for PRF of 0.5, 2, and 5 Hz, respectively.…”

Data_Sheet_1_Interplay Between Nanoplastics and the Immune System of the Mediterranean Sea Urchin Paracentrotus lividus.pdf by Carola Murano (10302947)

“…Upon transfer to PS NP-free CF, a significant decrease in fluorescence signal is observed, suggesting a fast cell clearance. …”

Cytoprotective gene regulation is essential to lifespan extension by diverse mechanisms. by David E. Shore (123998)

“…Lifespan was measured in three replicates comprising an average of 103 worms per condition. Data is presented as mean lifespan (columns 1–4), change mean lifespan in comparison to an empty vector RNAi control (column 5), or as the change in the extension of lifespan induced by each long-lived mutant (columns 6–8; for clarity, only decreases >15% are shown). …”

Determinants of Renal Tissue Oxygenation as Measured with BOLD-MRI in Chronic Kidney Disease and Hypertension in Humans by Menno Pruijm (541636)

“…The mean cortical and medullary R2* values ( = 1/T2*) were calculated before and after administration of IV furosemide, a low R2* indicating a high tissue oxygenation. …”

Changes in lacrimal tear and ocular surface parameters preoperatively, 1 day, 1 and 2 months postoperatively from preoperative value. by Yuli Park (772773)

“…(C) Change in corneal staining score from preoperative value. There was a statistically significant decrease in the corneal staining score at 1 and 2 months postoperatively but the dry eye group showed higher score than the no dry eye group (<i>P</i> <0.05). …”

Deletion of CDKAL1 Affects High-Fat Diet–Induced Fat Accumulation and Glucose-Stimulated Insulin Secretion in Mice, Indicating Relevance to Diabetes by Tadashi Okamura (118212)

“…In accordance with the findings in mice, a nominally significant (<em>P</em><0.05) association between <em>CDKAL1</em> rs4712523 and BMI was replicated in 2 Japanese general populations comprising 5,695 and 12,569 samples; the risk allele for type 2 diabetes was also associated with decreased BMI.…”

VCC-induced in vivo pro-inflammatory response and toxicity are TLR-dependent. by Shraddha Gandhi (21001590)

“…Right panel shows the colonization efficacies of WT and Δ<i>hlyA V. cholerae</i>. Mice were infected orally with the bacteria (5x10⁹ cells). …”