Experimental and Computational Insight into the Mechanism of NO Binding to Ferric Microperoxidase. The Likely Role of Tautomerization to Account for the pH Dependence by Maria Oszajca (1833010)

“…From the pH dependence of the second-order rate constant for NO binding (<i>k</i>_on), we determined individual rate constants characterizing forms <b>1</b>–<b>3</b>, revealing only a ca. 10-fold decrease in the NO binding rate on going from <b>1</b> (<i>k</i>_on^(<b>1</b>) = 3.8 × 10⁶ M^–1 s^–1) to <b>2</b> (<i>k</i>_on^(<b>2</b>) = 4.0 × 10⁵ M^–1 s^–1) and the inertness of <b>3</b>. …”

RelA–TA2 docks itself onto a series of interlinked hydrophobic grooves of TAZ1 through a number of hydrophobic residues, which serve as anchor points. by Sulakshana P. Mukherjee (453389)

“…The Leu449Ala and Leu465Ala mutants in RelA–TA2 lead to diminished association constants accompanied with decreased negative enthalpy change. …”

Illustration of MAD-FC transform and plot. by Bruce A. Corliss (8725967)

“…Column definitions for (<b>A</b>): |FCU|, absolute fold change units; Direction, whether fold change datapoint is negative/decreasing (–) or positive/increasing (+), or no change (NC); FC: fold change value; MFC, fold change value after mirror transform; MAD-FC, fold change value after mirror and contraction transform.…”

Design of Benzyl-triazolopyrimidine-Based NADPH Oxidase Inhibitors Leads to the Discovery of a Potent Dual Covalent NOX2/MAOB Inhibitor by Beatrice Noce (16540800)

“…NADPH oxidases (NOXs) are enzymes dedicated to reactive oxygen species (ROS) production and are implicated in cancer, neuroinflammation, and neurodegenerative diseases. VAS2870 is a covalent inhibitor of mainly NOX2 and NOX5. It alkylates a conserved active-site cysteine, blocking productive substrate binding. …”

Impairment of autophagy decreases trimethylation at H3K4 in human monocytes. by Kathrin Buffen (651914)

Heatmap of fold-changes of metabolites. by Elena Heidenreich (6940475)

“…A) Metabolite fold-change per cell, B) Metabolite fold-change per POC.…”

HIV Tropism and Decreased Risk of Breast Cancer by Nancy A. Hessol (191696)

Cardamonin induced apoptosis and decreased the MMP of ovarian cancer cells. by Peiguang Niu (17044532)

Decreased efficiency of RNAP II termination and increased gene expression following the loss of histone H3.V. by David Reynolds (695731)

<i>Syx5</i> suppression in human cells decreases copper accumulation but does not affect rate of turnover. by Melanie Norgate (234832)

Retinoic acid decreases ATF-2 phosphorylation and sensitizes melanoma cells to taxol-mediated growth inhibition-5 by Ying Huang (53474)

Virion production is significantly decreased by rapamycin treatment. by Lisa A. Nichols (357612)

6-OHDA-treated monkeys have decreased PGP9.5-ir in cardiac nerve bundles and fibers. by Valerie Joers (319079)

“…<p>(<b>A–D</b>) Microphotographs of PGP9.5-positive nerve bundles (<b>A,B</b>) and fibers (<b>C,D</b>) in control and 6-OHDA-treated animals. …”

Image_5_Decreased Type I Interferon Production by Plasmacytoid Dendritic Cells Contributes to Severe Dengue.jpeg by Vinit Upasani (4169677)

Population entropy in APP/PS1 mice is decreased in dCA1, but increased in vCA1. by Udaysankar Chockanathan (18510288)

Decreased motor neuron survival in E18.5 GAD67-deficient (−/−) hypoglossal and phrenic motor nuclei. by Matthew J. Fogarty (283288)

Retnla overexpression decreased the levels of IL-4, IL-5, and IL-13 in OVA-induced asthmatic lung. by Mi-Ran Lee (664596)

Figure 5 from Ammonia Suppresses the Antitumor Activity of Natural Killer Cells and T Cells by Decreasing Mature Perforin by Joanna Domagala (21643925)

“…<p>Ammonia decreases the amount of mature perforin in NK cells. …”

<b>Adipose TGR5 deletion promotes hepatic steatosis through decreasing adiponectin secretion in mice</b> by Jiahui Li (646449)

Acute intestinal inflammation transiently decreases frequency of colonic LP CD5⁺ B cells. by Yoshiyuki Mishima (842248)