HEWL interacts with dissipated oleic acid micelles, and decreases oleic acid cytotoxicity by Qin Huang (49441)

Subjects:

Synthesis and Antiproliferative Activity of a New Series of Mono- and Bis(dimethylpyrazolyl)‑<i>s</i>‑triazine Derivatives Targeting EGFR/PI3K/AKT/mTOR Signaling Cascades by Ihab Shawish (13015516)

“…Compound <b>4f</b> exhibited potent EGFR inhibitory activity with an IC₅₀ value of 61 nM compared to that of Tamoxifen (IC₅₀ value of 69 nM), with EGFR inhibition of 83 and 84%, respectively, at a concentration of 10 μM. Interestingly, <b>4f</b> showed remarkable PI3K/AKT/mTOR inhibitory activity with 0.18-, 0.27-, and 0.39-fold decrease in their concentration (reduction in controls from 6.64, 45.39, and 86.39 ng/mL to 1.24, 12.35, and 34.36 ng/mL, respectively). …”

Synthesis and Antiproliferative Activity of a New Series of Mono- and Bis(dimethylpyrazolyl)‑<i>s</i>‑triazine Derivatives Targeting EGFR/PI3K/AKT/mTOR Signaling Cascades by Ihab Shawish (13015516)

“…Compound <b>4f</b> exhibited potent EGFR inhibitory activity with an IC₅₀ value of 61 nM compared to that of Tamoxifen (IC₅₀ value of 69 nM), with EGFR inhibition of 83 and 84%, respectively, at a concentration of 10 μM. Interestingly, <b>4f</b> showed remarkable PI3K/AKT/mTOR inhibitory activity with 0.18-, 0.27-, and 0.39-fold decrease in their concentration (reduction in controls from 6.64, 45.39, and 86.39 ng/mL to 1.24, 12.35, and 34.36 ng/mL, respectively). …”

Overtrained mice show dichotomous modulation of timing-dependent synaptic depression (tLTD) in response to a change in the prevailing A–O contingency. by Vincent Paget-Blanc (21807763)

Predicted slope in 4-year intervals on the HOVs on a 4-point scale in GSOEP data. by Oscar Smallenbroek (17509563)

Proportion of NKG2D^-NKG2A^- cells among CD56^dim NK cells according to the dose of anti-thymocyte globulin. by Youngmin Ko (3333819)

Time concordance metrics for all TFs, pathways as well as genes using both a minimal |logFC| of 0.5 and 1. by Anika Liu (8411805)

vFLIP maintains intestinal barrier integrity in a short term model <i>in vivo</i>. by Barbara Ruder (8379354)

The primer information. by Guangxiao Ni (19713106)

“…MiR-199a-5p decreased the expression of PIK3R2 after MCAO, activated Akt signaling pathway, and increased the expression of Claudin-5 and VEGF in the ischemic penumbra. …”

Evans Blue extravasation between groups. by Guangxiao Ni (19713106)

“…MiR-199a-5p decreased the expression of PIK3R2 after MCAO, activated Akt signaling pathway, and increased the expression of Claudin-5 and VEGF in the ischemic penumbra. …”

Effect of imidacloprid (Im) and rutin (Ru) administration on thoracic electric currents in Africanized honey bee foragers. by Juan P. Hernández (22216133)

Identification of metabolites with cell type-specific-dynamics reveals the amino acid class as highly conserved in hiPSC and hNSC and that most of the cell type-specific amino acid... by João Vasconcelos e Sá (8721594)

Frequency Chart for optimal maxima case (Frequency = 1.714) (a), second optimal maxima case (Frequency = 1.692) (b), optimal minima case (Frequency = 0.946) (c) and second optimal... by Muhammad Hammad Bucha (21736111)

LuxR G37V has decreased DNA-binding activity. by Chelsea A. Simpson (9579303)

Immunoblotting for TGF-beta, alpha-actinin, MMP-13, and mTOR. by Dwight D. Harris (14484648)

“…There was a significant decrease in the ratio of pmTOR to mTOR. …”

Immunoblotting for JAK, STAT, and SMAD. by Dwight D. Harris (14484648)

“…There was also a significant decrease in SMAD and pSMAD in the SIT group. …”

Fibrosis markers. by Dwight D. Harris (14484648)

Immunoblotting for insulin sensitivity markers. by Dwight D. Harris (14484648)

“…There was also a significant decrease in pPKC alpha in the SIT-I myocardium compared to SIT-N. …”

S5 Fig - by Meghan J. Hirsch (16528311)

“…However, these relatively early time points may not encompass downstream airway cell signaling in response to the chronic PA infections observed in people with cystic fibrosis. …”

Immunoblotting FOXO1 and insulin receptors. by Dwight D. Harris (14484648)