An Atypical Mitochondrial Carrier That Mediates Drug Action in <i>Trypanosoma brucei</i> by Juan P. de Macêdo (735541)

“…Conversely, over-expression of the carrier in procyclic forms increased parasite susceptibility more than 13-fold. Metabolomic analyses of parasites over-expressing TbMCP14 showed increased levels of the proline metabolite, pyrroline-5-carboxylate, suggesting a possible involvement of TbMCP14 in energy production. …”

Cytoprotective effect of cooling against chemotherapy drug-mediated toxicity in hair follicle-derived keratinocytes and flow cytometry-based quantification of cellular doxorubicin... by Christopher Dunnill (9525217)

“…Bars represent mean fold decrease (± SEM) in drug uptake for independent biological experiments (n = 3). …”

DEHP-induced DMRs in sperm promoters. by Julien Prados (743297)

“…The number of promoter showing a statistically not significant more than two-fold increase methylation level in DEHP condition is indicates in black on the bottom left of each graph, whereas the number of promoter showing a statistically not significant more of than two-fold decreased methylation in DEHP compared to control is indicates in black on the bottom right of each graph. …”

Expression of integrins in retinal AC under different glucose conditions. by Eui Seok Shin (151716)

“…This was mainly attributed with a nearly 2-fold decrease in the fluorescence intensity of α5 integrin, while the fluorescence intensity of β1 integrin did not change under various glucose conditions (not shown). …”

Characterization of changes in Ecrg4 gene expression in ME mucosal after NTHi infection. by Arwa Kurabi (344167)

“…Each gene expression data point represents gene arrays obtained from 2 independent sets of 20 C57BL/6J mice and expressed as fold change from the expression levels measured at time 0 hr (see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0061394#pone.0061394-Leichtle1" target="_blank">[32]</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0061394#pone.0061394-Ebmeyer2" target="_blank">[34]</a> for details). …”

Wet laboratory validation of in silico results. by Patrick Baum (235495)

“…Subsequent staining with Hoechst dye, Sytox Green and Lysotracker Red determined cell density, nuclear fragmentation, permeability and lysosomal mass per cell illustrated a strong decrease of cell density and an increase of nuclear fragmentation and lysosomal mass for Ex1 but not for BI5 treated cells. …”

RO5464466 blocked the production of progeny virus and inhibited an established influenza virus infection. by Lei Zhu (16642)

“…<p>(A) Decrease of progeny virus production in cells treated with RO5464466 and other reference compounds. 12-well plates were seeded with MDCK cells at a density of 1.5×10⁵ cells per well. …”

Dependence of measurement precision on signal intensity by G. Hamilton (28103)

“…All rights reserved</p> () versus as a function of reduced exposure times. Data from three sets of exposure times, our standard and two steps of 10-fold reduction of both Cy3 and Cy5, are shown for the same array as in . …”

Characterization of hematopoietic stem and progenitor cells from BM of young and aged KO-F mice vs. by Ling Tian (107492)

“…BM from aged KO-F mice had a significant increase in absolute number of SLAM cells (3.32-fold increase in aged KO-F mice as compared to WT-F mice, p = 0.0150), and a concomitant decrease in the MPP compartment. …”

Gene expression across aphid biotypes. by Holly L. Nichols (10702131)

“…Each expressed gene in the aphid genome is represented by a point. The x-axes show the log₂ fold change of each gene, with points to the right side of each plot indicating increased expression in the presence of symbionts, and points to the left showing decreased expression. …”

Effects of CANA on metabolites evaluated by metabolomics. by Dan Nakano (8775380)

“…Red circle indicates differential metabolites, which determined the condition of >1.5-fold increase with P<0.05 or <0.7-fold decrease with P<0.05. …”

Levels of miR-150 and miR-155 expression in central memory CD8 T cells by qPCR. by Gonzalo Almanza (246998)

“…<p>Fold modulation in F5 (<b>A</b>) and OT-I (<b>B</b>) IL-15-derived memory CD8 T cells. …”

Inhibition of myosin IIB activity increases the number and length of filopodia-like protrusions. by Jennifer L. Hodges (207936)

“…MIIB knockdown creates an increase in the fraction of thin (long protrusions with small head at tip) and filopodia-like spines (long protrusions without a spine head) with a concomitant decrease in the fraction of mushroom and stubby spines, F. …”

table_1_In Utero and Postnatal Propylthiouracil-Induced Mild Hypothyroidism Impairs Maternal Behavior in Mice.DOCX by Miski Aghnia Khairinisa (5213834)

“…As expected, locomotor and cognitive functions in these mice were disrupted in a PTU dose-dependent manner. On postpartum day 2, dams who had been exposed 50 ppm PTU during in utero and postnatal periods displayed a significantly longer time identifying the first pup and returning all three pups back to the nest, less time nursing, and decreased licking behavior. …”

table_2_In Utero and Postnatal Propylthiouracil-Induced Mild Hypothyroidism Impairs Maternal Behavior in Mice.DOCX by Miski Aghnia Khairinisa (5213834)

“…As expected, locomotor and cognitive functions in these mice were disrupted in a PTU dose-dependent manner. On postpartum day 2, dams who had been exposed 50 ppm PTU during in utero and postnatal periods displayed a significantly longer time identifying the first pup and returning all three pups back to the nest, less time nursing, and decreased licking behavior. …”

image_1_In Utero and Postnatal Propylthiouracil-Induced Mild Hypothyroidism Impairs Maternal Behavior in Mice.EPS by Miski Aghnia Khairinisa (5213834)

“…As expected, locomotor and cognitive functions in these mice were disrupted in a PTU dose-dependent manner. On postpartum day 2, dams who had been exposed 50 ppm PTU during in utero and postnatal periods displayed a significantly longer time identifying the first pup and returning all three pups back to the nest, less time nursing, and decreased licking behavior. …”

Deletion of RBPJK enhances cell spontaneous differentiation in regular MSC culture. by Xifu Shang (784529)

“…<p>Mesenchymal stem cells were infected with Control shRNA(Co) or RBPJK shRNA (shRBPJK) lentivirus before being harvested for alkaline phosphatase (ALP) staining, western blot, RT-PCR analysis and BrdU ELISA. (A) Western Blot showed a significant decrease of RBPJK protein expression at day 3 and 14 following shRBPJK lentiviral infection. …”

Effects of various chemical decontaminants on Salmonella Typhimurium survival in chicken carcasses by Okan AGIRDEMIR (10463419)

“…Typhimurium. There was a significant decrease in the 1.5 ppm ozone treatment group (5 min and 15 min) as compared with that in the other chemical decontaminant groups (p < 0.05). …”

Quantification of specific polyadenylated transcripts upon egg aging. by Anna Kosubek (239172)

“…The transcripts are named according to the corresponding gene symbols listed in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0013532#pone.0013532.s004" target="_blank">Table S1</a> and were selected based on their >4-fold decrease in the microarray upon egg aging. …”

Temporal Trends in Exposures to Six Phthalates from Biomonitoring Data: Implications for Cumulative Risk by Jeanette M. Reyes (1306353)

“…Over this period, there was a 2.2-fold decrease in the mean HI (0.34 to 0.15) and a 7.2-fold decrease in the percentage of participants with an HI > 1 (5.7% to 0.8%), indicating an overall decrease in combined exposure to these phthalates. …”