Image_4_Multi-omics analysis identifies IgG2b class-switching with ALCAM-CD6 co-stimulation in joint-draining lymph nodes during advanced inflammatory-erosive arthritis.tif by H. Mark Kenney (10320665)

“…Integration of single-cell and spatial transcriptomics revealed the increased IgG2b⁺ plasma cells localized in MARCO⁺ peri-follicular medullary sinuses. A concomitant decreased Fth1 expression (Early 2.5 ± 0.74 vs Advanced 1.0 ± 0.50 counts, p<0.001) within Advanced PLN sinuses was associated with accumulation of iron-laden Prussian blue positive macrophages in lymph nodes and synovium of Advanced TNF-Tg mice, and further validated in RA clinical samples. …”

Image_1_Multi-omics analysis identifies IgG2b class-switching with ALCAM-CD6 co-stimulation in joint-draining lymph nodes during advanced inflammatory-erosive arthritis.tif by H. Mark Kenney (10320665)

“…Integration of single-cell and spatial transcriptomics revealed the increased IgG2b⁺ plasma cells localized in MARCO⁺ peri-follicular medullary sinuses. A concomitant decreased Fth1 expression (Early 2.5 ± 0.74 vs Advanced 1.0 ± 0.50 counts, p<0.001) within Advanced PLN sinuses was associated with accumulation of iron-laden Prussian blue positive macrophages in lymph nodes and synovium of Advanced TNF-Tg mice, and further validated in RA clinical samples. …”

Image_2_Multi-omics analysis identifies IgG2b class-switching with ALCAM-CD6 co-stimulation in joint-draining lymph nodes during advanced inflammatory-erosive arthritis.tif by H. Mark Kenney (10320665)

“…Integration of single-cell and spatial transcriptomics revealed the increased IgG2b⁺ plasma cells localized in MARCO⁺ peri-follicular medullary sinuses. A concomitant decreased Fth1 expression (Early 2.5 ± 0.74 vs Advanced 1.0 ± 0.50 counts, p<0.001) within Advanced PLN sinuses was associated with accumulation of iron-laden Prussian blue positive macrophages in lymph nodes and synovium of Advanced TNF-Tg mice, and further validated in RA clinical samples. …”

Image_3_Multi-omics analysis identifies IgG2b class-switching with ALCAM-CD6 co-stimulation in joint-draining lymph nodes during advanced inflammatory-erosive arthritis.tif by H. Mark Kenney (10320665)

“…Integration of single-cell and spatial transcriptomics revealed the increased IgG2b⁺ plasma cells localized in MARCO⁺ peri-follicular medullary sinuses. A concomitant decreased Fth1 expression (Early 2.5 ± 0.74 vs Advanced 1.0 ± 0.50 counts, p<0.001) within Advanced PLN sinuses was associated with accumulation of iron-laden Prussian blue positive macrophages in lymph nodes and synovium of Advanced TNF-Tg mice, and further validated in RA clinical samples. …”

Mendelian randomization highlights the causal role of normal thyroid function on blood lipid profiles by Yanjun Wang (9719672)

Table_1_Diel Patterns of Variable Fluorescence and Carbon Fixation of Picocyanobacteria Prochlorococcus-Dominated Phytoplankton in the South China Sea Basin.docx by Yuyuan Xie (2614804)

“…We found that phytoplankton photosynthetic performance at stations SEATS and SS1 were characterized by a nocturnal decrease, dawn maximum, and midday decrease of the maximum quantum yield of PSII (Fv(′)/Fm(′), which has been denoted as both F_v/F_m and Fv′/Fm′) in the nutrient-depleted surface layer. …”

Structure Based Identification and Characterization of Flavonoids That Disrupt Human Papillomavirus-16 E6 Function by Jonathan J. Cherry (501180)

The interplay between tauopathy and aging through interruption of UPR/Nrf2/autophagy crosstalk in the Alzheimer’s disease transgenic experimental models by Javad Amini (15446400)

Anti-inflammatory effects and beneficial effects of the feed additive <i>Urtica cannabina</i> L. in zebrafish by Wu Dong (1376829)

SUD Raw data.zip by Xiaoding Zhang (17976626)

Data_Sheet_1_Brain Activity Associated With Regulating Food Cravings Predicts Changes in Self-Reported Food Craving and Consumption Over Time.DOCX by Nicole R. Giuliani (9632423)

“…However, most research on this topic is limited to one follow-up time point, and single outcome measures. The present study seeks to add to that literature by employing a more refined assessment of food craving and consumption outcomes along with a more detailed neurobiological model of behavior change over several time points. …”

Table_1_Transcriptome analysis provides insights into the response of Lotus corniculatus roots to low-phosphorus stress.xlsx by Xin Zhao (71840)

“…Meanwhile, the main pathways, such as carbohydrate metabolism, acid phosphatases, phosphate transporters and biosynthesis of secondary metabolites, as well as related genes were also screened by performing a KEGG enrichment analysis.</p>Discussion<p>The findings provide an essential point of reference for studying the physiological and molecular mechanism of the response to low-P stress in L. corniculatus.…”

Limb survival dependence on Tie2 in the autoamputation model. by Michael Lekas (134183)

“…(f) Quantification of adductor muscle perfusion capacity on day 14 expressed as a vessel score that is a composite of vessel branching point number, length and end points number. …”

Changes in connectivity strength and network metrics during resting state and task periods. by Thomas P. K. Breckel (455915)

“…Attentionally resilient subjects (blue) began to recover during the post-task phase and showed a decrease in functional connectivity in the direction of the pre-task values, whereas attentionally impaired subjects (red) showed further increases in global connectivity strength until the end of the measurement (see also <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0074125#pone-0074125-g005" target="_blank">Figure 5</a> A). …”

Markers of osteoclast-mediated bone remodeling is reactivated in ColI(2.3)⁺/Rs1⁺ cochlea. by Omar Akil (558393)

“…<p>Markers of bone remodeling were assessed by immunohistochemistry on dissected 12-week-old male WT and ColI(2.3)⁺/Rs1⁺ cochlea with moderate (Mod) and severe (Sev) fibrous lesions using quantitative PCR. (<b>A</b>) Rs1 transgene expression was absent in WT controls and elevated in moderate (**, p = 0.01) and elevated 30-fold in severe ColI(2.3)⁺/Rs1⁺ cochlea (***, p<0.001). …”

Vulnerability to high fat diet-induced obesity. by Alessandro Bartolomucci (165364)

“…At baseline, when mice were fed standard diet, all experimental groups showed a decrease in body weight, while controls (Con) showed a slight increase (F(3,23) = 3.2, p<0.05). …”

Polymerization kinetics of <i>Plasmodium</i> actins. by Andrea J. Lopez (4990781)

“…Raw data related to panels a-d can be found in <a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1011174#ppat.1011174.s028" target="_blank">S5 Data</a>, panels e and f in <a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1011174#ppat.1011174.s029" target="_blank">S6 Data</a>, and panels g and h in <a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1011174#ppat.1011174.s030" target="_blank">S7 Data</a>.…”

Ex vivo fitness, CTL escape phenotype and sequence evolution of <i>gag</i> p24 CTL escape mutants. by Ryan M. Troyer (265934)

“…The fold escape conferred by each mutation is displayed here as the ratio of effective peptide concentration (EC₅₀) required to elicit 50% of maximal ELISpot signal relative to the pre-escape peptide <a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1000365#ppat.1000365-Cao2" target="_blank">[54]</a>. …”

Structure–Activity Relationship Studies of Pyrimidine-4-Carboxamides as Inhibitors of <i>N</i>‑Acylphosphatidylethanolamine Phospholipase D by Elliot D. Mock (9930184)

“…Conformational restriction of an <i>N</i>-methylphenethylamine group by replacement with an (<i>S</i>)-3-phenylpiperidine increased the inhibitory potency 3-fold. Exchange of a morpholine substituent for an (<i>S</i>)-3-hydroxypyrrolidine reduced the lipophilicity and further increased activity by 10-fold, affording <b>LEI-401</b> as a nanomolar potent inhibitor with drug-like properties. …”

Selective Enrichment of Cysteine-Containing Phosphopeptides for Subphosphoproteome Analysis by Mingming Dong (1471396)

“…Interestingly, amino acid residues surrounding the identified phosphosites were enriched with buried residues (L, V, A, C) while depleted with exposed residues (D, E, R, K). …”