The–log p-value graphs for the LOO-W analysis for <i>BRCA2</i>, <i>BRCA1</i> and <i>SMG1</i>. by Cavin Wong (7330154)

“…<p>A decrease in the–log p-value is an increase in p-value signifying the window dropped contains variants driving the association with PC risk. …”

Analysis of the errors in function of location and neural activity for rat R2192. by Ardi Tampuu (3906790)

“…Color of each hexagon depicts the average euclidean error of data points falling into the hexagon. More frequently visited areas (as seen from (a)) tend to have lower mean error. …”

Expression of components of the SUMOylation machinery. by Jinlin Li (2267896)

“…The results are shown as fold change relative to the expression at time 0. …”

Zerovalent [Pd(NHC)(Alkene)_1,2] Complexes Bearing Expanded-Ring N‑Heterocyclic Carbene Ligands in Transfer Hydrogenation of Alkynes by Peter Hauwert (2003662)

“…Their strong σ-donor character is reflected in a decrease in IR stretching frequency for the CO bond of the maleic anhydride ligands (<b>8</b>–<b>14</b>) in comparison to their five-membered counterparts. …”

Osmotic Pressure Simulations of Amino Acids and Peptides Highlight Potential Routes to Protein Force Field Parameterization by Mark S. Miller (1641355)

“…For five neutral amino acids, we also demonstrate a decrease in solute–solute attractions using the recently reported TIP4P-D water model and using the KBFF force field. …”

Feijoa F3 does not activate autophagy or inhibit NF-κB activity in autophagy defective HCT116 cells. by Noha Ahmed Nasef (760610)

“…Each experimental condition for solvent, media, and feijoa F3 had 3 biological replicates with two technical replicates (giving a maximum of 6 data points) and Torin1 had 2 biological replicates with two technical replicates (giving a maximum of 4 data points). …”

Feijoa F3 activates autophagy and inhibits NF-κB activity in HCT15 cells. by Noha Ahmed Nasef (760610)

“…Each experimental condition for solvent, media, and feijoa F3 had 3 biological replicates with two technical replicates (giving a maximum of 6 data points) and Torin1 had 2 biological replicates with two technical replicates (giving a maximum of 4 data points). …”

Highly Twisted Triarylamines for Photoinduced Intramolecular Charge Transfer by J. Matthew Chudomel (2178890)

“…Solution-phase (ensemble) time-resolved photoluminescence measurements show up to 4-fold decreases in fluorescence lifetime in acetonitrile compared to hexane. …”

Comparison of the overlap of DNA methylation probes with epigenetic marks showed the outcome of DIM-mediated alteration in DNA methylation may be influenced by local histone modifi... by Carmen P. Wong (512550)

“…A randomized control set was generated by reshuffling the genomic positions of each dataset (light and dark gray bars for decreased methylation and increased methylation, respectively). …”

Age-Related Changes following In Vitro Stimulation with <i>Rhodococcus equi</i> of Peripheral Blood Leukocytes from Neonatal Foals by Priyanka Kachroo (107357)

“…We found induction of genes critical for host immunity against pathogens (MHC class II) only at the later time-points (compared to birth). While it appears that foals up to 8-weeks of age are able to initiate a protective inflammatory response against the bacteria, relatively decreased expression of various other immune-related genes points toward inherent diminished immune responses closer to birth. …”

Edge time series, computed as the element-wise product of two z-scored calcium time series, measures instantaneous co-fluctuation between pairs of nodes pre- (left) and post- (righ... by Douglas Blackiston (234987)

“…In pre- puncture networks there is no clear pattern in co-fluctuations across the organoids, though in post- puncture networks there is a general decrease from strong co-fluctuations and amplitudes to some baseline levels.…”

Time-course of mRNA expression of IGF-system genes and the activation levels of signalling mediators in the E18.8 cochlea. by Hortensia Sanchez-Calderon (186893)

“…<p>(<b>A–D</b>) mRNA expression levels of <i>Igf1</i>, <i>Igf1r</i>, <i>Igfbp2</i> and <i>Igfbp3</i> were analyzed by qRT-PCR in <i>Igf1^+/+</i> (open circles) and <i>Igf1^−/−</i> (closed circles) mice at E15.5 and E18.5 (n = 8), P5, P15, P30, P60 and P90 (n = 6). …”

Polyglutamine Induced Misfolding of Huntingtin Exon1 is Modulated by the Flanking Sequences by Vinal V. Lakhani (249536)

Guanine metabolism. by Patricia Kuzaj (635687)

“…(d) Metabolic pathway of purine breakdown of guanine, including enzymatic steps of guanine deaminases (GDA) and xanthine oxidoreductases (XOR) with formation of reactive oxygen species (ROS). Arrows point to the comparison of patients and healthy controls: red (significantly increased), green (significantly decreased), light green (decreased, by trend), yellow (unchanged).…”

Growth inhibition of BT474 cells by targeting Y211 phosphorylation of PCNA. by Huajun Zhao (189292)

“…</b> DNA synthesis activity in the treated cells was determined by a colorimetric BrdU-incorporation analysis. For each data point, the amount of incorporated BrdU was normalized to the percentage of viable cells, as determined by a side-by-side MTT assay. …”

Paclitaxel induced polyneuropathy can be detected with the Catwalk method. by Petra Huehnchen (470721)

“…The swing phase (squares, long dashed line) increases, while the stance phase (open triangles, dotted line) and the duty cycle (circles, solid line) decreases. Duty cycle expresses the stance phase as a percentage of the entire step cycle (stand + swing). …”

Fig 2 - by Azam Shahvaroughi-Farahani (10924390)

“…<i>(</i><b><i>b</i></b><i>) Experiment 2 (Arm length estimate−Tactile/proprioceptive approach)</i>: Participants seated with eyes closed while estimating the length of their right/left arm (plus hand) on the table by using a tactile starting point. The participant then was instructed to move the right index finger on the table towards the right to indicate the length of his/her right/left arm (plus hand).…”

GSNO reduces fibrin branchpoint density, but does not alter the fiber density/branchpoint ratio. by Ryon M. Bateman (141170)

“…Panels A,B,C show a multiphoton image with three branch points (B1,B2,B3) and their corresponding contour map and surface plots, respectively. …”

ITDs and azimuthal head-turn angle. by Laura Hausmann (257760)

“…<p>(A) The azimuthal head-turn angles were pooled for stimulation with individualized HRTFs (dotted, owls H and S), responses to owl 39 normal (black, all three owls) and to owl 39 ruffcut (blue, all three owls). …”

Site-specific mutagenesis of MAEL HMG-box domain. by Pavol Genzor (711322)

“…(C-F) Mutation of individual arginines (R) results in the complete loss of binding to DNA 4WJ suggesting that they are essential for complex formation. The R8A mutant fold appears to be affected (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0120268#pone.0120268.s002" target="_blank">S2B Fig.…”