Synthesis and Antiproliferative Activity of a New Series of Mono- and Bis(dimethylpyrazolyl)‑<i>s</i>‑triazine Derivatives Targeting EGFR/PI3K/AKT/mTOR Signaling Cascades by Ihab Shawish (13015516)

“…Compound <b>4f</b> exhibited potent EGFR inhibitory activity with an IC₅₀ value of 61 nM compared to that of Tamoxifen (IC₅₀ value of 69 nM), with EGFR inhibition of 83 and 84%, respectively, at a concentration of 10 μM. Interestingly, <b>4f</b> showed remarkable PI3K/AKT/mTOR inhibitory activity with 0.18-, 0.27-, and 0.39-fold decrease in their concentration (reduction in controls from 6.64, 45.39, and 86.39 ng/mL to 1.24, 12.35, and 34.36 ng/mL, respectively). …”

Synthesis and Antiproliferative Activity of a New Series of Mono- and Bis(dimethylpyrazolyl)‑<i>s</i>‑triazine Derivatives Targeting EGFR/PI3K/AKT/mTOR Signaling Cascades by Ihab Shawish (13015516)

“…Compound <b>4f</b> exhibited potent EGFR inhibitory activity with an IC₅₀ value of 61 nM compared to that of Tamoxifen (IC₅₀ value of 69 nM), with EGFR inhibition of 83 and 84%, respectively, at a concentration of 10 μM. Interestingly, <b>4f</b> showed remarkable PI3K/AKT/mTOR inhibitory activity with 0.18-, 0.27-, and 0.39-fold decrease in their concentration (reduction in controls from 6.64, 45.39, and 86.39 ng/mL to 1.24, 12.35, and 34.36 ng/mL, respectively). …”

Monitoring of the weight of guinea pigs treated with anti-EBOV IgGs. by Olivier Reynard (354756)

DnaK associates with intact ribosomes and not with dismantled ribosomes. by Carissa Chan (18310140)

Trigger factor hinders DnaK-mediated reduction of protein synthesis. by Carissa Chan (18310140)

Preparations of DnaK protein are pure. by Carissa Chan (18310140)

DnaK does not refold heat-denatured luciferase when incubated in the presence of ribosomes. by Carissa Chan (18310140)

Patients’ histories are presented in decreasing length of observation and colour coded as red for the days of use or referred use and green for abstinence days. by Francesco Lolli (2530471)

Proportion of insertions under positive selection as a function of population size. by Thomas LaBar (739568)

Final number of evolved phenotypic traits as a function of population size. by Thomas LaBar (739568)

Image_2_Reaching and maintaining higher dietary diversity is associated with decreased risk of all-cause mortality: A longitudinal study from the China Health and Nutrition Survey.... by Xiaochen Qu (13861271)

“…In summary, reaching and maintaining a higher DDS was associated with a decreased risk of all-cause mortality. …”

Image_1_Reaching and maintaining higher dietary diversity is associated with decreased risk of all-cause mortality: A longitudinal study from the China Health and Nutrition Survey.... by Xiaochen Qu (13861271)

“…In summary, reaching and maintaining a higher DDS was associated with a decreased risk of all-cause mortality. …”

<i>Slc13a5</i>^<i>-/-</i> mice had decreased enamel volume as measured with μCT. by Armando R. Irizarry (422739)

GXM decreases the trans-endothelial electrical resistance (TEER) and transmigration of <i>C</i>. <i>neoformans</i> through HBECs in a blood brain barrier (BBB) model. by Hiu Ham Lee (15374677)

The Role of Genetically Modified Mesenchymal Stem Cells in Urinary Bladder Regeneration by Devon C. Snow-Lisy (798898)

“…Blood vessel and bladder functionality were evident at both time-points in all animals. Results from this study indicate that MSC-based Cyr61OX and Wnt5aOX cell lines play pivotal roles with regards to increasing the levels of functional vasculature, influencing muscle regeneration, and the regeneration of peripheral nerves in a model of bladder augmentation. …”

Reduced follicles, decreased ovulation and decreased fertilization of female Meox-2-cre/Separase S1121A mutant mice. by Juan Xu (225010)

Depletion of PfPKAc in NF54/AP2-G-mScarlet/PKAc cKD parasites leads to a block in merozoite invasion and decreases gametocyte rigidity. by Eva Hitz (10877688)

Change from full-scale to reduced model in sum (across all time points and grids) of squared error between model and MC scan data as a function of the number of clusters used in th... by Monica E. Shapiro (22622240)

Immunohistochemistry of Ki67, PCNA, and α-SMA was performed on the VX2 tumor rabbit model at days 1, 2, 5 and 7 after nsPEF ablation. by Qing-Gang Li (273341)

List of FLC-evolved strains with different <i>ERG251</i> point mutations. by Xin Zhou (54275)