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point decrease » point increase (Expand Search)
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Lipid Droplet-Binding Protein TIP47 Regulates Hepatitis C Virus RNA Replication through Interaction with the Viral NS5A Protein
Published 2013“…A single point mutation (W9A) in NS5A that disrupts the interaction with TIP47 but preserves proper subcellular localization severely decreased HCV RNA replication. …”
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1543
a-c: Bone marrow (BM) HIF2 α is inappropriately decreased in uremic anemia.
Published 2018“…<p>BM HIF2 α protein (depicted as percentage of actin-corrected concentration) increases in 7 day-bled rats (Fig 2a) Vs control. Contrary to that, BM HIF2 α protein decreases in uremic (4 weeks after 5/6 nephrectomy) rats (Fig. 2b). …”
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1544
<i>Ex vivo</i> deletion of <i>sirt1</i> decreases expression of RUNX2 downstream targets.
Published 2017“…<b>C)</b> While SIRT1 knockout osteoblasts (Cre) express comparable amounts of Runx2, they show a near two-fold reduction in the expression of the Runx2 downstream target, <u>Osterix</u> (Osx). …”
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1545
Overexpression of cathepsin K in mice decreases collagen deposition and lung resistance in response to bleomycin-induced pulmonary fibrosis-2
Published 2011“…(A), data are given as fold change in cathepsin K mRNA of bleomycin-challenged cath K tg mice compared to wild-type mice. …”
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S2 Data -
Published 2023“…For diabetes, HealthRise was associated with A1c decreases in Ramsey (1.3 [0.4–2.2]). Qualitative data showed the value of home visits alongside clinic-based services; however, challenges remained, including community health worker retention and program sustainability.…”
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Overexpression of cathepsin K in mice decreases collagen deposition and lung resistance in response to bleomycin-induced pulmonary fibrosis-6
Published 2011“…Ned in lysates of alveolar macrophages and lung parenchymal tissue of mock-treated cath K tg mice as compared to mock-treated wild-type mice (A). In addition, cathepsin K protein was determined in lysates of alveolar macrophages (B), freshly isolated type II alveolar epithelial cells (C), lung parenchymal tissue (D), and concentrated BAL fluid supernatant (E) of mock-treated cath K transgenic and wild-type mice by western blot analysis. …”
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Overexpression of cathepsin K in mice decreases collagen deposition and lung resistance in response to bleomycin-induced pulmonary fibrosis-0
Published 2011“…Ned in lysates of alveolar macrophages and lung parenchymal tissue of mock-treated cath K tg mice as compared to mock-treated wild-type mice (A). In addition, cathepsin K protein was determined in lysates of alveolar macrophages (B), freshly isolated type II alveolar epithelial cells (C), lung parenchymal tissue (D), and concentrated BAL fluid supernatant (E) of mock-treated cath K transgenic and wild-type mice by western blot analysis. …”
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1553
Perturbing the ORF57-REF/Aly interaction with point mutations decreases cytoplasmic accumulation of viral mRNA.
Published 2011“…Point mutations of ORF57 residues implicated in direct interaction with REF, and reducing its binding, all caused significant decrease in cytoplasmic accumulation of viral mRNA.…”
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Adaptation to cool temperature decreases basal and stimulated lipolysis and increases <i>de novo</i> lipogenesis and TAG synthesis.
Published 2021“…ACC, acetyl-CoA carboxylase; ATGL, adipose triglyceride lipase; GSEA, gene set enrichment analysis; FASN, fatty acid synthase; HSL, hormone-sensitive lipase; NEFA, nonesterified fatty acid; PL, phospholipid; TAG, triacylglycerol; TOFA, 5-(tetradecyloxy)-2-furoic acid.…”
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Decreased methylglyoxal-mediated protein glycation in the healthy aging mouse model of ectopic expression of UCP1 in skeletal muscle
Published 2023“…In aged HSA-mUCP1 mice, urinary MG-derived AGEs/FL ratio was decreased ca. 60% whereas there was no change in CML/FL ratio – a marker of oxidative damage. …”
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1560
Table_1_Urban-driven decrease in arthropod richness and diversity associated with group-specific changes in arthropod abundance.DOCX
Published 2023“…Urbanisation level was estimated by five different proxies extracted from land use/land cover data (e.g., impervious surface cover), all of them calculated in a 100, 500, and 1,000 m radius around the sampling points, and three indexes based on distance to settlements. …”