Architecture of P2Y Nucleotide Receptors:  Structural Comparison Based on Sequence Analysis, Mutagenesis, and Homology Modeling^† by Stefano Costanzi (82273)

“…The mutation of Y306 (7.35, site of a cationic residue in P2Y₁₂) or Y203 in the second extracellular loop selectively decreased the affinity of the agonist 2-MeSADP, and the Y306F mutation also reduced antagonist (MRS2179) affinity by 5-fold. …”

Architecture of P2Y Nucleotide Receptors:  Structural Comparison Based on Sequence Analysis, Mutagenesis, and Homology Modeling^† by Stefano Costanzi (82273)

“…The mutation of Y306 (7.35, site of a cationic residue in P2Y₁₂) or Y203 in the second extracellular loop selectively decreased the affinity of the agonist 2-MeSADP, and the Y306F mutation also reduced antagonist (MRS2179) affinity by 5-fold. …”

Architecture of P2Y Nucleotide Receptors:  Structural Comparison Based on Sequence Analysis, Mutagenesis, and Homology Modeling^† by Stefano Costanzi (82273)

“…The mutation of Y306 (7.35, site of a cationic residue in P2Y₁₂) or Y203 in the second extracellular loop selectively decreased the affinity of the agonist 2-MeSADP, and the Y306F mutation also reduced antagonist (MRS2179) affinity by 5-fold. …”

Architecture of P2Y Nucleotide Receptors:  Structural Comparison Based on Sequence Analysis, Mutagenesis, and Homology Modeling^† by Stefano Costanzi (82273)

“…The mutation of Y306 (7.35, site of a cationic residue in P2Y₁₂) or Y203 in the second extracellular loop selectively decreased the affinity of the agonist 2-MeSADP, and the Y306F mutation also reduced antagonist (MRS2179) affinity by 5-fold. …”

Architecture of P2Y Nucleotide Receptors:  Structural Comparison Based on Sequence Analysis, Mutagenesis, and Homology Modeling^† by Stefano Costanzi (82273)

“…The mutation of Y306 (7.35, site of a cationic residue in P2Y₁₂) or Y203 in the second extracellular loop selectively decreased the affinity of the agonist 2-MeSADP, and the Y306F mutation also reduced antagonist (MRS2179) affinity by 5-fold. …”

Architecture of P2Y Nucleotide Receptors:  Structural Comparison Based on Sequence Analysis, Mutagenesis, and Homology Modeling^† by Stefano Costanzi (82273)

“…The mutation of Y306 (7.35, site of a cationic residue in P2Y₁₂) or Y203 in the second extracellular loop selectively decreased the affinity of the agonist 2-MeSADP, and the Y306F mutation also reduced antagonist (MRS2179) affinity by 5-fold. …”

Architecture of P2Y Nucleotide Receptors:  Structural Comparison Based on Sequence Analysis, Mutagenesis, and Homology Modeling^† by Stefano Costanzi (82273)

“…The mutation of Y306 (7.35, site of a cationic residue in P2Y₁₂) or Y203 in the second extracellular loop selectively decreased the affinity of the agonist 2-MeSADP, and the Y306F mutation also reduced antagonist (MRS2179) affinity by 5-fold. …”

Architecture of P2Y Nucleotide Receptors:  Structural Comparison Based on Sequence Analysis, Mutagenesis, and Homology Modeling^† by Stefano Costanzi (82273)

“…The mutation of Y306 (7.35, site of a cationic residue in P2Y₁₂) or Y203 in the second extracellular loop selectively decreased the affinity of the agonist 2-MeSADP, and the Y306F mutation also reduced antagonist (MRS2179) affinity by 5-fold. …”

Combined Effects of <i>TGFB1</i> +869 T/C and +915 G/C Polymorphisms on Acute Rejection Risk in Solid Organ Transplant Recipients: A Systematic Review and Meta-Analysis by Yu-Zheng Ge (285709)

“…Overall, a significantly decreased risk was detected in patients carried with intermediate producer (IP) haplotypes (T/C G/C, T/T G/C, and C/C G/G) and/or low producer (LP) haplotypes (C/C G/C, C/C C/C, T/T C/C, and T/C C/C) compared with high producer (HP) haplotypes (T/T G/G and T/C G/G; IP vs. …”

DataSheet_1_A Chinese Prescription Yu-Ping-Feng-San Administered in Remission Restores Bronchial Epithelial Barrier to Inhibit House Dust Mite-Induced Asthma Recurrence.pdf by Kaifan Bao (6017810)

“…This study aims to evaluate the efficacy and mechanism of a potent Chinese prescription Yu-Ping-Feng-San (YPFS) against asthma recurrence. …”

Table 1_Associated effects of lipopolysaccharide, oleic acid, and lung injury ventilator-induced in developing a model of moderate acute respiratory distress syndrome in New Zealan... by Xingyu Tian (17791894)

“…The present study sought to induce a moderate ARDS model in New Zealand White rabbits with a model involving a mix of lipopolysaccharide (LPS), oleic acid (OA), and ventilation-induced lung injury (VILI). …”

DataSheet_1_The incidence risk of breast and gynecological cancer by antidepressant use: A systematic review and dose–response meta-analysis of epidemiological studies involving 16... by Yanjia Zhuang (13957293)

“…</p>Results<p>Based on a systematic literature search, 34 eligible studies (27 case–control studies and 7 cohort studies) involving 160,727 female breast and gynecological cancer patients found that antidepressant use did not increase the incidence risk of female breast and gynecological cancer (pooled OR: 1.01; 95% CI: 0.97, 1.04, I² = 71.5%, p < 0.001), and even decreased the incidence risk of ovarian cancer (pooled OR: 0.91; 95% CI: 0.83, 1, I² = 17.4%, p = 0.293). …”

DataSheet_1_The incidence risk of breast and gynecological cancer by antidepressant use: A systematic review and dose–response meta-analysis of epidemiological studies involving 16... by Yanjia Zhuang (13957293)

“…</p>Results<p>Based on a systematic literature search, 34 eligible studies (27 case–control studies and 7 cohort studies) involving 160,727 female breast and gynecological cancer patients found that antidepressant use did not increase the incidence risk of female breast and gynecological cancer (pooled OR: 1.01; 95% CI: 0.97, 1.04, I² = 71.5%, p < 0.001), and even decreased the incidence risk of ovarian cancer (pooled OR: 0.91; 95% CI: 0.83, 1, I² = 17.4%, p = 0.293). …”

DataSheet_1_The incidence risk of breast and gynecological cancer by antidepressant use: A systematic review and dose–response meta-analysis of epidemiological studies involving 16... by Yanjia Zhuang (13957293)

“…</p>Results<p>Based on a systematic literature search, 34 eligible studies (27 case–control studies and 7 cohort studies) involving 160,727 female breast and gynecological cancer patients found that antidepressant use did not increase the incidence risk of female breast and gynecological cancer (pooled OR: 1.01; 95% CI: 0.97, 1.04, I² = 71.5%, p < 0.001), and even decreased the incidence risk of ovarian cancer (pooled OR: 0.91; 95% CI: 0.83, 1, I² = 17.4%, p = 0.293). …”

Protein aggregation of LPO treated with different HOCl concentrations. by Carlos Eduardo A. Souza (338908)

“…<p>Upper panel depicts the reducing SDS-PAGE of LPO treated with HOCl, showing a decrease in the main LPO band, and a concomitant increase of high molecular weight aggregates. …”

Image_7_TGF-β2 Induces Gli1 in a Smad3-Dependent Manner Against Cerebral Ischemia/Reperfusion Injury After Isoflurane Post-conditioning in Rats.TIF by Li Peng (83452)

“…Transforming growth factor beta (TGF-β) and hedgehog (Hh) signaling pathways govern a wide range of mechanisms in the central nervous system. …”

Table_1_TGF-β2 Induces Gli1 in a Smad3-Dependent Manner Against Cerebral Ischemia/Reperfusion Injury After Isoflurane Post-conditioning in Rats.XLS by Li Peng (83452)

“…Transforming growth factor beta (TGF-β) and hedgehog (Hh) signaling pathways govern a wide range of mechanisms in the central nervous system. …”

Image_9_TGF-β2 Induces Gli1 in a Smad3-Dependent Manner Against Cerebral Ischemia/Reperfusion Injury After Isoflurane Post-conditioning in Rats.TIF by Li Peng (83452)

“…Transforming growth factor beta (TGF-β) and hedgehog (Hh) signaling pathways govern a wide range of mechanisms in the central nervous system. …”

Image_3_TGF-β2 Induces Gli1 in a Smad3-Dependent Manner Against Cerebral Ischemia/Reperfusion Injury After Isoflurane Post-conditioning in Rats.TIF by Li Peng (83452)

“…Transforming growth factor beta (TGF-β) and hedgehog (Hh) signaling pathways govern a wide range of mechanisms in the central nervous system. …”

Image_11_TGF-β2 Induces Gli1 in a Smad3-Dependent Manner Against Cerebral Ischemia/Reperfusion Injury After Isoflurane Post-conditioning in Rats.TIF by Li Peng (83452)

“…Transforming growth factor beta (TGF-β) and hedgehog (Hh) signaling pathways govern a wide range of mechanisms in the central nervous system. …”