Mithramycin Exerts an Anti-Myeloma Effect and Displays Anti-Angiogenic Effects through Up-Regulation of Anti-Angiogenic Factors by Eléonore Otjacques (410361)

“…The administration of MTM to mice injected with 5TGM1 decreased 5TGM1 cell invasion into bone marrow and myeloma neovascularisation. …”

Compound 1294 interferes in host cell invasion. by Kayode K. Ojo (353587)

“…Cultures were maintained in the absence of 1294 (B), in the presence of 2.5 μM 1294 added 2 h post-invasion (C), and in the presence of 2.5 μM 1294 added already at the time point of invasion (D). …”

Frequency distributions of the <i>γ</i> values for the parameter sets that yield circadian oscillation. by Kazuhiro Maeda (182174)

“…<p>The frequency distributions of the quantitative balance between <i>X</i> and <i>Y</i> loops (<i>γ</i>) were simulated, while changing the kinetic symmetry (<i>ρ</i>): <i>ρ</i>≥99 (cross), <i>ρ</i> = 1 (circle), <i>ρ</i> = 0.1 (square), <i>ρ</i> = 0.01 (diamond). A decrease in <i>ρ</i> increases the kinetic symmetry. …”

Basal LDLR gene expression and activity is higher in PC-3 than LNCaP cells. by James Robert Krycer (104817)

“…Expression is represented as a fold change (relative to PC-3 cells), whereby a one-unit increase in ΔC_t results in a two-fold decrease in mRNA expression. …”

Proton Transfer and Structure-Specific Fluorescence in Hydrogen Bond-Rich Protein Structures by Dorothea Pinotsi (1305144)

“…The importance of proton transfer on the intrinsic fluorescence observed in protein fibrils is signified by large reductions in the fluorescence intensity upon either fully protonating, or deprotonating, the fibrils at pH = 0 or 14, respectively. Thus, our results point to the existence of a structure-specific fluorophore that does not require the presence of aromatic residues or multiple bond conjugation that characterize conventional fluorescent systems. …”

Increased S129-P-α-synuclein in acutely treated curcumin mice. by Kateri J. Spinelli (293686)

“…(n = 2 mice for DMSO treatment, n = 3 mice for curcumin treatment; each data point represents the average value for a 3μm z-stack, with 4–12 z-stacks analyzed per mouse; pink arrows indicate colocalized synapses, white arrows indicate lack of colocalization; *p<0.05,**p<0.01,***p<0.001, Scale bar = 5 μm).…”

Proton Transfer and Structure-Specific Fluorescence in Hydrogen Bond-Rich Protein Structures by Dorothea Pinotsi (1305144)

“…The importance of proton transfer on the intrinsic fluorescence observed in protein fibrils is signified by large reductions in the fluorescence intensity upon either fully protonating, or deprotonating, the fibrils at pH = 0 or 14, respectively. Thus, our results point to the existence of a structure-specific fluorophore that does not require the presence of aromatic residues or multiple bond conjugation that characterize conventional fluorescent systems. …”

Proton Transfer and Structure-Specific Fluorescence in Hydrogen Bond-Rich Protein Structures by Dorothea Pinotsi (1305144)

“…The importance of proton transfer on the intrinsic fluorescence observed in protein fibrils is signified by large reductions in the fluorescence intensity upon either fully protonating, or deprotonating, the fibrils at pH = 0 or 14, respectively. Thus, our results point to the existence of a structure-specific fluorophore that does not require the presence of aromatic residues or multiple bond conjugation that characterize conventional fluorescent systems. …”

Flux changes and osmotic stress kinetic order distribution in osmotic conditions (0.3 M). by Guido Santos (171018)

“…<p><b>A.</b> Mean flux changes in logarithmic scale of (the mean of) the selected solutions. …”

Stability of beta-titanium T-loop springs preactivated by gradual curvature by Sergei Godeiro Fernandes Rabelo Caldas (4791744)

“…Results: The horizontal forces decreased gradually among the groups (p< 0.001) and the moments showed a significant and slow decrease over time among the groups (p< 0.001). …”

Cardiovascular and respiratory effects of lumbosacral epidural bupivacaine in isoflurane-anesthetized dogs: The effects of two volumes of 0.25% solution by Raquel Sartori Gonçalves Dias (5117654)

“…Mean arterial pressure decreased significantly from 15 to 90 minutes after the administration of BUP02 and from 5 to 60 minutes in BUP04, with lower values in BUP04 than in BUP02 lasting up to 30 minutes after bupivacaine administration. …”

Cerebral vasomotor reactivity in migraine: effect of patent foramen ovale and aerogenic microembolism by Farid Khasiyev (9273491)

“…</p> <p>Presence of PFO correlated with a significant decrease of MCA BHI (1.43 ± 0.39 vs 1.04 ± 0.67, p = 0.032) and marginal reduction of PCA BHI (1.25 ± 0.46 vs. 1.01 ± 0.39, p = 0.090) in migraineurs. …”

Table1_The feasibility and safety of his-purkinje conduction system pacing in patients with heart failure with severely reduced ejection fraction.docx by Chengming Ma (15775178)

“…At implantation, the CSP threshold was 0.6 ± 0.3 V @ 0.4 ms and remained stable during a mean follow-up of 23.43 ± 11.44 months. …”

Presentation1_The feasibility and safety of his-purkinje conduction system pacing in patients with heart failure with severely reduced ejection fraction.pptx by Chengming Ma (15775178)

“…At implantation, the CSP threshold was 0.6 ± 0.3 V @ 0.4 ms and remained stable during a mean follow-up of 23.43 ± 11.44 months. …”

Gene expression patterns correlated to methapyrilene-mediated hepatotoxicity by J. Todd Auman (69692)

“…Each point on the graph represents the average expression value of the top 5 genes in the pattern for each microarray performed. …”

Experience-dependent and temporally restricted serotonin signaling and synaptic glomeruli pruning. by Vanessa Kay Miller (19775496)

“…Two-way ANOVA with Tukey’s multiple comparison shows a highly significant decrease in the Or42a OSN innervation (<i>n</i> = 28/condition, <i>p</i> = 7.45 × 10⁻¹¹) and increase in serotonin (<i>n</i> = 28/condition, <i>p</i> = 4.10 × 10⁻¹⁴). …”

Effects of L-arginine hydrochloride infusion on venous blood chloride concentrations. by Tsin W. Yeo (218400)

“…<p><a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0002347#pone-0002347-g005" target="_blank">Figure 5A</a>: Relationship between dose/weight (mg/kg) of infused L-arginine and the maximal decrease in venous blood chloride at any time during or in the two hours following infusion (n = 30, r = 0.6, p<0.001). …”

Kinetics of T and DHT and their predicted effects on prostatic gene occupancy. by Michael G. Zager (138879)

“…(Middle right panel) Prostatic DHT concentrations are decreased due to dropping levels of blood DHT and prostatic 5aR2 inhibition. …”

Datasheet1_Trends in hypertension and hypertension treatment in primary care in general practices in Germany between 2013 and 2022.pdf by Karel Kostev (2577346)

“…After adjusting for covariates, there was a significant decrease in the number of patients diagnosed with hypertension (beta coefficient = −7.91, p-value < 0.001) and treated with any antihypertensive drug per practice per year between 2013 and 2022 (beta coefficient = −5.40, p-value < 0.001).…”

Random forest identified stop codon identity, P-site amino acid identity, and 3’-UTR length as factors critical in readthrough efficiency prediction. by Kotchaphorn Mangkalaphiban (9767180)

“…<p><b>A.</b> Performance metric for random forest regression displaying average Normalized Root Mean Squared Error (NRMSE) ± standard deviation across 5-fold cross-validation. …”