Mmp10 is necessary for <i>Kras^LA2</i>-induced lung tumorigenesis <i>in vivo.</i> by Roderick P. Regala (168909)

“…Statistical analysis using Mann-Whitney U test revealed a significant decrease in higher grade tumors in <i>Kras^LA2/Mmp10^−/−</i> mice; *p<0.002.…”

Figure 2 by Kazuo Konishi (195884)

“…<p>A) DNA methylation status of thirteen cancer-specific or age-related genes/CpG islands in 16 primary CRCs and matched liver metastasis. …”

Results of MC simulations of VO and agonist infusion. by Johane H. Bracamonte (12883844)

“…<p>Top panels show normalized growth in CellArea for 100 representative simulations (gray lines), with terminal values indicated by black circles; adjacent boxplots reflect the mean, CI50, and CI90 of terminal values for 1000 simulations of a) Untreated VO, c) ISO infusion, and e) AngII infusion. …”

Treatment of gp130^757FF mice with WP1066 reduces tumour size. by Louise M. Judd (185660)

“…Antral tumours in 8 week untreated mice (A) and 10 week DMSO-treated vehicle controls (B) were no different in mean area, however WP1066 treatment resulted in ∼50% smaller tumours (C). …”

Co-expression of PGRN rescues the axonopathy induced by Mt TDP-43 but not Mt SOD1. by Angela S. Laird (360986)

“…<p>A) Staining of primary motor axons with an anti-synaptic vesicle 2 revealed a decrease in axonal length and increase in aberrant branching in embryos expressing Mt TDP-43 compared with Wt TDP-43. …”

Increase of intrinsic apoptosis in irradiated HNSCC cancer stem cells. by Anthony Boivin (298008)

“…<p>After cell sorting, two sub-populations were obtained from the SQ20B carcinoma cell line: CD44⁺ cancer stems cells (A, C, E) and a CD44⁻ side population (B, D, F) which were grown in the SQ20B culture medium for 10 days. …”

Characterization of lipid rafts isolated from the nerve trunks and their role in the organization of GIR. by Caroline Fasano (76332)

“…The low density fraction (3) exhibited high cholesterol content and low protein/cholesterol ratio compared to the high density fractions. b, c, Western blot analysis of the gradient fractions showed the enrichment of the fraction 3 in ganglioside GM1 and annexin II. c, d, decrease in annexin II (Western blot) in the rafts fraction isolated from the nerve trunks and depletion of cholesterol by 10 mM MβCD (mean of four assays from one experiment, see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0000612#s4" target="_blank">methods</a>). …”

Extension, twist and writhe changes of DNA during nucleosome-wrapping. by Chunhong Long (6858428)

“…(B) The mean extension increment resulting from nucleosome wrapping is a function of supercoil and stretching force. …”

Echocardiographic characteristics by patient group based on initial qualitative RV assessment of “normal”, “mild/mod” and “severe” RV enlargement. by Chad S. Weldy (9628603)

“…<p>(A) RV end diastolic area (cm²) (RVEDA) and (B) RV end systolic area (cm²) (RVESA) increased with mild-moderate and severe RV enlargement, (C) right atrial area (cm²) increased with severe RV enlargement, (D) RV fractional area change (RVFAC) showed a trend toward a decrease with severe RV enlargement, (E) RV free wall Lagrangian longitudinal strain (RVLS) showed a trend toward an increase with severe RV enlargement, and (F) LV ejection fraction (LVEF%) was similar in all groups, N = 4-11/group. …”

TSLPR-deficiency and IL-7R blockade alter numbers of thymocytes and splenocytes. by Maarten R. Hillen (760783)

“…Total numbers of splenocytes were decreased in anti-IL-7R treated TSLPR-/- mice compared to PBS treated WT mice (C), associated with a decrease in CD4+ and CD8+ T-cells in the anti-IL-7R treated TSLPR-/- mice (D). …”

Whole-cell [Ca²⁺]_i transients in hiPSC-CMs and their requirement for Ca²⁺ influx via L-type Ca²⁺ channels. by Ilanit Itzhaki (225708)

“…<p>(<b>A</b>) Confocal line-scan images showing changes in intracellular Ca²⁺ in a fluo-4 loaded hiPSC-CM (derived from the hIH1 line). …”

Modeling limb enhancers sequence composition and its integration with chromatin information. by Remo Monti (4379632)

“…(<b>B</b>) Same as (A) but showing AUPRC. (<b>C</b>) Bar plot showing the average coefficient from the LASSO models for those sequence features selected in 9/10 of splits during LASSO training and reported in the top 25% in terms of mean decrease in accuracy, as estimated during RF training. …”

Contribution of <i>hlgABC</i> to USA300 virulence in mouse infection models and survival in human blood. by Natalia Malachowa (224375)

“…(C) Survival of wild-type and Δ<i>hlgABC</i> strains in heparinized human blood. There were 1.5×10⁷ LAC wild-type CFUs at 0 min and this number decreased to 2.4×10⁶ CFUs by 120 min. …”

HMGB1 induces Src activation. by Mengchen Zou (725646)

“…EA.hy926 cells were plated in the upper part of transwell chambers until the formation of a tight monolayer. The cells were preincubated with 1, 2.5, 5, 10 or 20μM PP2 (upper) or 0.5, 1, 2.5, 5 or 10 μM CGP77675 (lower) for 1 h, respectively. …”

HIV/AIDS case definition criteria and association between sociodemographic and clinical aspects of the disease reported in the State of Minas Gerais from 2007 to 2016 by Sybelle de Souza Castro (5668175)

“…By contrast, a consequent decrease was observed in the number of criteria used for defining cases, which were adapted from the Centers for Disease Control and Prevention, Rio de Janeiro/Caracas, and for identifying AIDS-related deaths. …”

Changes in human intervertebral disc biochemical composition and bony end plates between middle and old age by Delio Eulalio Martins (5759282)

“…</p><p>Results</p><p>The old-aged group showed a decrease in content of sulphated and non-sulphated glycosaminoglycans relative to middle-aged and there were also alterations in the proportion of GAG disaccharides and a decrease of collagen fiber size. …”

Data_Sheet_1_Climate Warming Increased Spring Leaf-Out Variation Across Temperate Trees in China.pdf by Yaru Zhang (484892)

“…Furthermore, the LOV changes between 1987–2008 and 1963–1986 were significantly smaller at high latitudes (average decrease of 1.0 day) than at low latitudes (average increase of 1.5 days). …”

Acute Toxicity of Silver Free and Encapsulated in Nanosized Zeolite for Eukaryotic Cells by Clément Anfray (3923939)

“…After exposure to Ag⁺-EMT (50 μg/mL) for 24 h, a loss in cell viability independent of the cell type was observed, ranging from −34.37 ± 23.90% for astrocytes to −99.5 ± 0.24% for U87-MG cells. …”

Donor and Geometry Optimization: Fresh Perspectives for the Design of Polyoxometalate Charge Transfer Chromophores by Bethany R. Hood (20396768)

“…The linear systems show that with julolidinyl (Jd) and −NTol₂ donor groups, the alkyne bridge yields high second-order nonlinear optical (NLO) coefficients β (Jd, β_0,<i>zzz</i> = 318 × 10^–30 esu; −NTol₂, β_0,<i>zzz</i> = 222 × 10^–30 esu), indeed the Jd compound gives the highest NLO activity of any organoimido-POM to date with minimal decrease in transparency. The <i>bis</i>-functionalized 2D (<i>C</i>_2v) POM derivative showed increased activity over its monofunctionalized analogue with no decrease in transparency, although the NLO response was only minimally two dimensional. …”

Data_Sheet_1_Current Perspectives on Achieving Pronounced Enteric Methane Mitigation From Ruminant Production.docx by Emilio M. Ungerfeld (5414681)

“…<p>Limiting global warming to 1.5°C above pre-industrial levels by 2050 requires achieving net zero emissions of greenhouse gases by 2050 and a strong decrease in methane (CH₄) emissions. …”