The Full Capacity of AICAR to Reduce Obesity-Induced Inflammation and Insulin Resistance Requires Myeloid SIRT1 by Zhenggang Yang (120148)

“…We previously showed that two nutrient sensors AMP-activated protein kinase (AMPK) and SIRT1 interact to regulate macrophage inflammation. AMPK is also a molecular target of 5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside (AICAR), which has been shown to reduce insulin resistance in various animal models. …”

Vitreous Olink Proteomics Uncovers Novel Inflammatory Proteins in Patients with Proliferative Diabetic Retinopathy by Jiayu Zhang (128702)

Retrospective analysis of our institutional experience on PF rates and stump closure techniques during DP (Department of Surgery, TU München, 2007–2015). by Elke Tieftrunk (5390732)

“…The overall PF rate was 27% (Grade A: 11%, Grade 2: 11%, Grade 3: 5% according to the ISGPS definition from 2005 [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0197553#pone.0197553.ref016" target="_blank">16</a>]). …”

Increase in fall-related hospitalization, mortality, and lethality among older adults in Brazil by Lígia Raquel Ortiz Gomes Stolt (10433995)

“…The North showed a decreasing hospitalization rate (48%), and the Southeast a stationary one (3%). …”

SI Appendix - Figure Legends.pdf by William Wan (8219789)

“…Traditional cell culture substrates are 5-6 orders of magnitude stiffer than even diseased native cardiac tissue. …”

Table_1_Downed woody debris varies with climate and harvesting treatment in Douglas-fir forests of British Columbia, Canada.docx by Winnifred Jean Roach (11011191)

“…Across a 900-km long latitudinal gradient in British Columbia, we found that coarse woody debris (CWD, >7.5 cm diameter) in humid climates contained 700% greater carbon stocks, had 500% greater volume, and was more diverse than in arid climates. …”

‘Stemness’ gene expression profiles and epigenetic mechanisms in Du145-VP16 cells. by Hong Yan (27984)

“…<p>A. Du145-VP16 cells show both decreases and increases in stemness gene expression levels. …”

DataSheet2_Tomographic Image of Shear Wave Structure of NE India Based on Analysis of Rayleigh Wave Data.pdf by Amit Kumar (81180)

“…The images obtained reveal a very complicated tectonic regime. The Bengal Basin comprises a thick layer of sediments with the thickness increasing from west to east and a sudden steepening of the basement on the eastern side of the Eocene Hinge zone. …”

FXR and PPAR α ligands protects against aortic plaques formation induced by the HIV-PI ritonavir to ApoE^−/− mice. by Andrea Mencarelli (134128)

“…<p><b>Panel A.</b> Administration of ritonavir (5 mg/kg/day) to ApoE^−/− for 12 weeks increases the size of aortic plaques expressed of ratio of plaque surface area to vessel surface area. …”

Stratification of cohort into HIV-1 disease progression groupings. by Jennifer Serwanga (374953)

“…Positive (+) symbols indicate increasing CD4+ counts while (−) indicates decreasing CD4+ counts over time. Individuals in the extreme stratification group 1 were selected as rapid progressors (RP, n = 7) while those in group 5 were selected as slow progressors (SP, n = 14). …”

Calmodulin (CaM) gel-overlay assay of the purified recombinant AtCyp19-3 and its truncated versions. by Gundeep Kaur (789528)

“…<b>(D)</b> Helical wheel projection (<a href="http://rzlab.ucr.edu/scripts/wheel/wheel.cgi" target="_blank">http://rzlab.ucr.edu/scripts/wheel/wheel.cgi</a>) of the predicted CaM-binding domain (CaMBD) of AtCyp19-3. …”

<i>Nbea</i>^+/^<i>−</i> mice show postnatal, sustained growth retardation and an altered body composition. by Kim Nuytens (645050)

“…(<b>C–F</b>) DEXA measurements were performed to analyze the body composition (n = 5/genotype; 12 weeks old). (<b>C</b>) <i>Nbea</i>^+/<i>−</i> mice have a reduced total tissue mass accompanied by an increase in percentage fat mass (<b>D</b>) and a decreased percentage lean mass (<b>E</b>). …”

Contrasting transcriptomes of somatic, OSKM transduced HFF1 and pluripotent cell types. by Nancy Mah (105583)

“…The normalized expression values (z-score) of 6179 transcripts (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0024351#pone.0024351.s007" target="_blank">Data S1</a>) regulated at any timepoint or in iPS/ES cells with respect to HFF1 cells (p_adj<0.05; fold change >1.5) are shown. …”

Image_1_Inactivation of Prefrontal Cortex Delays Emergence From Sevoflurane Anesthesia.eps by Emma R. Huels (10321976)

“…Ninety minutes after injection, rats were anesthetized with 2.5% sevoflurane and the time to loss of righting reflex, a surrogate for loss of consciousness, was measured. …”

Image_2_Inactivation of Prefrontal Cortex Delays Emergence From Sevoflurane Anesthesia.eps by Emma R. Huels (10321976)

“…Ninety minutes after injection, rats were anesthetized with 2.5% sevoflurane and the time to loss of righting reflex, a surrogate for loss of consciousness, was measured. …”

Gel filtration and EMSA analysis of the WT N protein purified from HEK293S GNTI- cells. by Amanda Jack (11547638)

“…<b>(F)</b> EMSA using no RNA, 10 nM 0–5 kb viral RNA, and 50 ng/μL polyC RNA and decreasing concentration of N protein. …”

Table_1.DOCX by Sipla Aggarwal (4912828)

“…Four non-segregating RNAi lines of wheat were selected for detailed study (S3-D-6-1; S6-K-3-3; S6-K-6-10 and S16-D-9-5). Homozygous transgenic RNAi lines at T₄ seeds with a decreased transcript of TaIPK1 showed 28–56% reduction of the PA. …”

Enabling <i>C</i>. <i>glabrata</i> to make or use HMP allows for synthesis of thiamine and growth in starvation conditions. by Christine L. Iosue (2576281)

“…<p>(A) Adding back <i>THI5</i> in the genome or on a plasmid restores growth to <i>C</i>. …”

OG33 and OG35 cells are recalcitrant to differentiation. by Patrick M. Long (487632)

“…<p>OG33 (A) and OG35 (B-D) cells were induced to differentiate over 6 days <i>in </i><i>vitro</i> via activation of adenylyl cyclase (1 mM dibutyryl cAMP or 10 μM forskolin) or inhibition of MEK1/2 (1 μM PD035901), ErbB2 (1 μM PD174285), PI3K (5 μM and 10 μM LY294002), or mTOR (10 nM and 20 nM rapamycin [RAP]) signaling. …”

Sulindac Compounds Facilitate the Cytotoxicity of β-Lapachone by Up-Regulation of NAD(P)H Quinone Oxidoreductase in Human Lung Cancer Cells by Hsiu-Ni Kung (138467)

“…In the second part, we found that the FDA-approved non-steroidal anti-inflammatory drug sulindac and its metabolites, sulindac sulfide and sulindac sulfone, increased NQO1 expression and activity in the lung adenocarcinoma cell lines CL1-1 and CL1-5, which have lower NQO1 levels and lower sensitivity to β-lapachone treatment than the A549 cell lines, and that inhibition of NQO1 by either dicoumarol treatment or NQO1 siRNA knockdown inhibited this sulindac-induced increase in β-lapachone cytotoxicity. …”