Visualizing the positive feedback triggered by Cdc42-GTP. by Iker Lamas (580641)

“…(Bottom) Time lapse as in top row, but normalized by subtraction of initial time-point signal and pseudocolored. Note side signal in Opto^Q61L cells (arrowheads), which represents gain of fluorescence intensity in respect to the initial time point (see <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.3000600#sec016" target="_blank">Methods</a>). …”

Diagrammatic illustrations to show the hypothetical effects of compensatory changes in skull dimensions and brain shape when there is craniosynostosis or shortening of certain skul... by Susan P. Knowler (522309)

“…<p>These figures were created using Adobe Photoshop (<a href="http://www.adobe.com/products/photoshopfamily.html" target="_blank">http://www.adobe.com/products/photoshopfamily.html</a>) which enables manipulation of shapes with fixed points facilitating a simple representation of the distortion. a) Normal; the skull is represented by a black box and brain by a grey circle with reference points w, x, y and z. …”

Mitochondrial OXPHOS activity of ATZ-treated rat skeletal muscle mitochondria. by Soo Lim (172772)

“…<p>Rats on a regular diet were treated with or without ATZ for 5 months. …”

Use of the Pareto set to define the patterns of primary/promiscuous activity modulation. by Hector Garcia-Seisdedos (158269)

“…(B), (C) and (D) are illustrative examples of the relation between the Pareto set (green data points) and the primary/promiscuous trade-offs. In (B) and (C) the starting variant (marked with a red circle) belongs to the Pareto set and, therefore, increasing the promiscuous activity necessarily implies a decrease of the primary activity. …”

Efficient trypanosome motility requires mechanical interaction with obstacles similar to red blood cells. by Niko Heddergott (120004)

“…Almost 90% of trypanosomes were classified as motile cells in arrays with 4 µm pillar distance, which corresponds to the mean spacing of erythrocytes in blood (n = 150). Wider spacing led to a sharp decrease in directional motility. (<i>C</i>) The dynamics of the cells net directional movement as represented by the mean squared displacement (MSD) plotted over the observation time points to a fast, super-diffusive swimming behavior in pillar arrays of 4 µm spacing. …”

Data_Sheet_1_Longitudinal study of mental health changes in residents affected by an initial outbreak of COVID-19 in China.DOC by Na Du (294594)

“…The mean PSS scores among the four time points showed significant differences (F = 183.98, P < 0.001), with the highest score at T1 (15.35 ± 7.14), a sharp decline at T2 (11.27 ± 6.27), an obvious rebound at T3 (15.17 ± 7.46), and finally a slight decrease at T4 (14.41 ± 7.99). …”

The Depsipeptide Romidepsin Reverses HIV-1 Latency <i>In Vivo</i> by Ole S. Søgaard (148120)

“…Here, we report a proof-of-concept phase Ib/IIa trial where 6 aviremic HIV-1 infected adults received intravenous 5 mg/m² romidepsin (Celgene) once weekly for 3 weeks while maintaining ART. …”

Table 1_Evaluation of the cardiorespiratory and antinociceptive effects of the total intravenous anesthesia technique with xylazine-butorphanol-propofol compared to isoflurane in c... by Shogo Sato (16544880)

“…<p>A novel total intravenous anesthesia (TIVA) technique combining xylazine (0.1 mg/mL), butorphanol (0.01 mg/mL), and propofol (2 mg/mL) in a 5% dextrose solution (XBP) has shown promising results in calves. …”

Nefopam modulates β-catenin protein level. by Raymond Poon (12265)

“…There is a decrease in β-catenin level with Nefopam treatment in cell cultures from both conditions. …”

Effects of stochastic channel gating alter the response to stellate cells to naturalistic stimuli. by Joshua T. Dudman (267282)

“…<p>(A,B) Plot of mean spike frequency (A) and coefficient of variation of the ISI distribution (B) as a function of the mean and standard deviation of band limited white noise inputs obtained from 5 s duration simulations (N = 384). …”

Varying temporal expression profiles of BDNF-mediated gene induction in E16 rat-derived striatal neurons. by Ozgun Gokce (213947)

“…The second set, represented by Ppm2c, Nab2, Klf5 and Baiap2, shows a more gradual and moderate fold increase rising to a peak within 3–6 hours after treatment and decreasing to near baseline levels within 12 hours. …”

Determinants of daily hearing aid use (Reed et al., 2025) by Nicholas S. Reed (22298786)

“…</p><p dir="ltr"><b>Results: </b>Every 1-year increase in prior hearing aid use was associated with 0.08-hr increase in daily hearing aid use (95% confidence interval [CI] [0.04, 0.13]); every 10-dB increase in PTA was associated with 0.63-hr increase in daily hearing aid use (95% CI [0.18, 1.08]); every 5-point increase in QuickSIN score was associated with 0.53-hr decrease in daily hearing aid use (95% CI [−0.99, −0.06]). …”

<i>Mecp2</i> deficient neurons and astroglia cells have significantly more chromocenters than wild type cells. by Bianca Bertulat (126768)

“…Unbiased analysis of data from three biological replicates (n = 100 per data set) for <i>Mecp2</i> wild type (solid line) and <i>Mecp2</i> deficient (dashed line) cells at different time points revealed significant decrease of chromocenters within the first two weeks of differentiation whereas extended differentiation time to 21 days did not result in further large scale heterochromatin remodeling. …”

Bursts in the nuc/cyt SMAD2 ratio are caused by anti-correlated changes in nuclear and cytoplasmic SMAD2 by Niklas Kolbe (11998394)

“…</div><div>In the scatter plot on the left each trajectory is represented by a blue dot and a red dot encoding nuclear and cytoplasmic SMAD2 at the time before and within a burst event respectively. …”

Video_2_Profiling of Blood-Brain Barrier Disruption in Mouse Intracerebral Hemorrhage Models: Collagenase Injection vs. Autologous Arterial Whole Blood Infusion.MP4 by Peijun Jia (11334594)

“…The results showed that the BBB leakage was associated with a decrease in TJ protein expression and an increase in MMP-9 activity and AQP4 expression on day 3 in the c-ICH model compared with that on day 5 in the b-ICH model. …”

Video_1_Profiling of Blood-Brain Barrier Disruption in Mouse Intracerebral Hemorrhage Models: Collagenase Injection vs. Autologous Arterial Whole Blood Infusion.MP4 by Peijun Jia (11334594)

“…The results showed that the BBB leakage was associated with a decrease in TJ protein expression and an increase in MMP-9 activity and AQP4 expression on day 3 in the c-ICH model compared with that on day 5 in the b-ICH model. …”

Pcl3 promotes ESC self-renewal. by Julie Hunkapiller (177548)

“…Graph represents average expression from 3–6 different clones. (B) A portion of cells transduced with <i>Pcl3</i> shRNA, but not scramble shRNA, are larger, flatter, and less dense, signifying a decrease in ESC cell morphology. …”

Image_1_Profiling of Blood-Brain Barrier Disruption in Mouse Intracerebral Hemorrhage Models: Collagenase Injection vs. Autologous Arterial Whole Blood Infusion.jpeg by Peijun Jia (11334594)

“…The results showed that the BBB leakage was associated with a decrease in TJ protein expression and an increase in MMP-9 activity and AQP4 expression on day 3 in the c-ICH model compared with that on day 5 in the b-ICH model. …”

Alterations of Marginal Zone (MZ) B cells during <i>T. brucei</i> infections. by Magdalena Radwanska (73816)

“…The decrease in total number of MZ B-cells per spleen was calculated for different time points during infection (B), based on the total amount of cells harvested per spleen at each time point (C). …”

DARPP-32 mediated signaling network shows dopamine-dependent gating of CaMKII/PP1 signaling and input-interval constraint. by Anu G. Nair (461390)

“…(C) The downstream response in terms of the amount of phosphorylated substrate (pSubstrate) for 10 pulses of calcium input at 10 Hz (leading to 5μM calcium concentration) with or without a dopamine (DA) pulse (1.5μM) (1.0s) following the calcium input. …”