The kinases TTBK1/2 phosphorylate TDP-43 in <i>C. elegans</i> and <i>in vitro</i>. by Nicole F. Liachko (669572)

“…<p>(A) Developmentally synchronized day 1 adult <i>dkf-2(−/−)</i>;TDP-43, <i>cdc-7(−/−)</i>;TDP-43, and H05L14.1(−/−);TDP-43 kinase mutants have decreased phosphorylated TDP-43 relative to TDP-43 transgenic animals alone. …”

Collapse regime, hysteresis, and recovery of plant–pollinator mutualistic networks. by Gaurav Baruah (7257587)

“…(B, C) As the transition parameter, which is <i>γ</i>₀, decreases, the mutualistic network transitions from a high-functioning stable state—high species richness in B and high biomass in C—to a low-functioning undesirable state—low richness in B and low biomass depicted by dark pink points. …”

ATP-Sensitive K⁺ Channel Knockout Induces Cardiac Proteome Remodeling Predictive of Heart Disease Susceptibility by D. Kent Arrell (2347204)

“…Forecasting disease susceptibility requires detection of maladaptive signatures prior to onset of overt symptoms. A case-in-point are cardiac ATP-sensitive K⁺ (K_ATP) channelopathies, for which the substrate underlying disease vulnerability remains to be identified. …”

Table_1_Independent and joint influence of depression and advanced lung cancer inflammation index on mortality among individuals with chronic kidney disease.DOCX by Jie Zhou (28945)

“…Each point increase in a patient’s PHQ-9 score increased the risk of all-cause mortality by 4% (HR, 1.04; 95% CI, 1.02–1.06; p < 0.001), in the full adjusted model. …”

Age-related reduction of Na, K-ATPase immunoreactivity in the stria vascularis. by Xinping Hao (570986)

“…<p>Sox10 (green) and Na, K-ATPase (31B) immunoreactivity (red) in the StV of a young adult (A–C) and an aged (D–F) mouse. …”

Table1_Placental treatment with insulin-like growth factor 1 via nanoparticle differentially impacts vascular remodeling factors in guinea pig sub-placenta/decidua.DOCX by Baylea N. Davenport (14324355)

“…Additionally, there are no effective in utero treatment options for FGR. We have developed a nanoparticle to deliver human insulin-like 1 growth factor (hIGF-1) in a trophoblast-specific manner which results in increased expression of hIGF-1. …”

Baseline characteristics for pneumonia. by Mathias Aagaard Christensen (19139443)

“…</p><p>Results</p><p>Models were generated for atrial fibrillation, venous thromboembolism and pneumonia as genetics only, clinical features only and a combined model. For venous thromboembolism, the ROC-AUCs were 60.1% [59.6%-60.4%], 63.4% [63.2%-63.4%] and 66.6% [66.2%-66.9%] for the linear models and 51.5% [49.4%-53.4%], 63.2% [61.2%-65.0%] and 62.6% [60.7%-64.5%] for the deep learning SNP, clinical and combined models, respectively. …”

Data_Sheet_1_Estimation of potato above-ground biomass based on unmanned aerial vehicle red-green-blue images with different texture features and crop height.docx by Yang Liu (4829)

“…The results show that (i) potato crop height and AGB first increase and then decrease over the growth period; (ii) GDS and scales mainly affect the correlation between GLCM- and Gabor-based textures and AGB; (iii) to estimate AGB, GLCM-based textures of GDS1 and GDS30 work best when the GDS is between 1 and 5 cm and 10 and 60 cm, respectively (however, estimating potato AGB based on Gabor-based textures gradually deteriorates as the Gabor convolution kernel scale increases); (iv) the AGB estimation based on a single-type texture is not as good as estimates based on multi-resolution GLCM-based and multiscale Gabor-based textures (with the latter being the best); (v) different forms of textures combined with crop height using the LSSVM technique improved by 22.97, 14.63, 9.74, and 8.18% (normalized root mean square error) compared with using only all GLCM-based textures, all Gabor-based textures, the former combined with crop height, and the latter combined with crop height, respectively. …”

Complexes with Redox-Active Ligands: Synthesis, Structure, and Electrochemical and Photophysical Behavior of the Ru(II) Complex with TTF-Annulated Phenanthroline by Lawrence K. Keniley (1936060)

“…Ru­(II) complexes with chelating ligands, 4′,5′-ethylene­dithio­tetra­thiafulvenyl­[4,5-<i>f</i>]­[1,10]­phenan­throline (<b>L1</b>), 1,3-dithiole-2-thiono­[4,5-<i>f</i>]­[1,10]­phenanthroline (<b>L2</b>), and 1,3-dithiole-2-ono­[4,5-<i>f</i>]­[1,10]­phenanthroline (<b>L3</b>), have been prepared and their structural, electrochemical, and photophysical properties investigated. …”

Mechanisms involved in the regulation of CD36 expression by tumor necrosis factor (TNF)α by Jean Frédéric Boyer (32017)

“…Human monocytes were incubated with macrophage-serum-free medium (M-SFM) alone (control), or with M-SFM containing TNFα (10 ng/ml) for 5, 30 or 60 minutes, and then stimulated, or not, with a synthetic ligand of PPARγ, rosiglitazone (R; 5 μmol/l) for 45 minutes. …”

miRNA expression microarray. by Masanori Kawano (798368)

“…<p>(A). Heat map of genome-wide miRNA profiles in five ES cell lines and hMSCs. …”

Characterization of glucose metabolism in imatinib-sensitive and -resistant cells. by Jérome Kluza (5649763)

“…Cells were then collected for total ATP measurement as described in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0021924#s2" target="_blank">Materials and Methods</a>. …”

Supplemental material for Fig 2. by Hannah Gordon (8729760)

“…(h) Quantification of the abundance of 561-Eos⁺ microglia in <i>Tg(pu1</i>:<i>Eos)</i> animals that had all microglia photoconverted a 3 dpf and then quantified at 6 dpf. Each data point with connect line represent a single animal. …”

Modeling glutamate-induced glutamate release (GIGR). by Saju Balakrishnan (58265)

“…<b><i>D</i></b>–To model calcium-free experiments (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0202802#pone.0202802.g003" target="_blank">Fig 3C</a>), the release rate was decreased 5-fold and glutamate transients rapidly diminished. …”

Myelin alteration in 8-week-old TRAF4-KO mice. by Sébastien Blaise (332585)

“…(C): Western blot analysis of the myelin-specific MBP marker and of the interglial-specific TJ marker claudin 11 (cl 11) showed a decreased expression level of both proteins in 4 independent TRAF4-KO cerebellum protein extracts (lanes 5–8) compared with 4 WT samples (lanes 1–4) ; tubulin served as a loading control. …”

Supplementary Material for: Visual Analysis of Biomarkers Reveals Differences in Lipid Profiles and Liver Enzymes before and after Gastric Sleeve and Bypass by vanBerckel M.M.G. (10103377)

<i>Sox2</i> and <i>Fgf20</i> interact during cochlea development—quantitative analysis. by Lu M. Yang (6919364)

“…Letters (L, I, J, O, P, S, T; representing each measurement in panels B-E) indicate a statistically significant decrease (p < 0.05) when comparing the row genotype against the column genotype. …”

Brine management strategies, technologies, and recovery using adsorption processes by Al-Absi R.S.

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Data_Sheet_1_Mechanical Determinants of the U-Shaped Speed-Energy Cost of Running Relationship.docx by Apolline Carrard (6093833)

“…<p>Purpose: The aim of this study was to investigate the relationship between the energy cost of running (Cr) and speed and its mechanical determinants by comparing running in normal [100% body weight (BW)] and reduced (20% and 60% BW) gravity conditions at several speeds (2.25, 3.17, 4.08, and 5.00 m·s⁻¹) in experienced runners.</p><p>Methods: Twelve experienced runners (24.6 ± 5.4 year) ran on an AlterG treadmill in a partially randomized order at the four running speeds and at the three gravity conditions in order to assess Cr, spatiotemporal parameters, spring-mass characteristics and elastic energy (EL) during running.…”

Temporal Variation of Soil Physical Quality under Conventional and No-Till Systems by Carlos Germán Soracco (5112683)

“…Under NT, most dynamic indicators increase from BS to V6 and decrease again at AH, whereas under CT, they follow a different trend, decreasing from BS to V6, remaining constant until R5, and increasing at AH. …”