The NK1-receptor antagonist ezlopitant significantly inhibits both sucrose and ethanol operant self-administration in rats. by Pia Steensland (362091)

“…<p>Ezlopitant (2, 5, 10 mg/kg i.p.) dose dependently decreases self-administration of 5% sucrose (<b>A</b>). …”

Evidence from cell culture assays that ZAP inhibits retrotransposition. by John L. Goodier (126693)

“…(E) Overexpression of HA-ZAP-L, HA-ZAP-S, rat HA-NZAP, and V5-TEV-MOV10 constructs strongly decreased Alu retrotransposition in HeLa-HA cells. …”

Is the risk of progressive multifocal leukoencephalopathy the real reason for natalizumab discontinuation in patients with multiple sclerosis? by Julia Krämer (436881)

“…Questionnaires were completed at 5 different time points. Patients were stratified into 5 subgroups according to the presence of PML risk factors (prior immunosuppression, anti-JCV antibody status, treatment duration). …”

In the CE3b-group, the AgB-specific IL-4 response changed over time independently of therapy. by Linda Petrone (339785)

“…The treatment led to cyst solidification (CE4 at T1) in 4/5 of patients with CE3b at T0: 2 patients showed a IL-4 decline; one patient showed almost no change and one patient showed an increase. …”

Effect of Telomerase Depletion on the Differentiation of Human CD34+ Progenitor Cells. by Aparna Raval (14624)

“…<p>(A-B) Scatter plots showing median values for (A) pRb and (B) pATM expression in CD34-LKS CD150hi, CD150lo and CD150neg populations from WT <i>Tert</i>+/+ (n = 4), G0 <i>Tert</i>+/- (n = 4), G5 <i>Tert</i>-/- (n = 4) and TxG5 <i>Tert</i>-/- (n = 4) mice. …”

DNA epitope vaccine improves acquisition and retention of spatial memory in immune mice. by Nina Movsesyan (86328)

“…<p>A) The escape latency to reach the platform was significantly decreased in the groups of non-transgenic (n = 6) and 3xTg-AD immune mice (n = 9) versus age-matched groups of MDC-irrelevant control (n = 5) and non-vaccinated control 3xTg-AD mice (n = 5). …”

Effects of etravirine on HIV-1 reverse transcriptase, recovered from plasma of HIV-1 infected patients. by Eva Agneskog (593818)

“…Based on the IC₅₀ value of BH10-wild-type (1.0±0.18 µM), which was included in every run, the IC₅₀ value and the fold-difference in susceptibility of each isolate were determined. A fold-difference of <5 was considered as sensitive, between 5–15 as decreased susceptibility, and above 15 as resistant.…”

qRT-PCR assays. by Michiel van Boxelaere (4610947)

“…<p>(A) Hippocampal gene expression analysis revealed significantly decreased TH mRNA levels (n = 5) and DAT (n = 5) mRNA levels of UCMS exposed BL6 mice, relative to unexposed controls. …”

Dose-Dependent Effects of Morphine Exposure on mRNA and microRNA (miR) Expression in Hippocampus of Stressed Neonatal Mice by Ryan M. McAdams (128412)

“…Control mice were untreated and dam-reared. mRNA and miR expression profiling was performed on hippocampal tissues at P9. Overall, 2 and 5 mg/kg morphine treatment altered expression of a total of 150 transcripts (>1.5 fold change, P<0.05) from which 100 unique mRNAs were recognized (21 genes were up- and 79 genes were down-regulated), and 5 mg/kg morphine affected 63 mRNAs exclusively. …”

Distribution of modulated genes. by Doreswamy Kenchegowda (135193)

Effect of E protein on the recognition of prM protein by human anti-prM mAbs. by Wen-Yang Tsai (108058)

“…<p>(A) Binding specificity of 4 human anti-prM mAbs including 2 CR (DVB59.3 and DVB18.5) and 2 sCR (DVB65.5 and DVB32.4) mAbs was determined as in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0052600#pone-0052600-g005" target="_blank">Figure 5</a>. …”

DATA ALL PARTICIPANTS.xlsx by Angela Van Sickle (20441450)

“…An additional purpose was to investigate the same parameters using a 5 mL swallow of water. Participants were divided into three groups: young adults (n = 65,= 22.8 years), middle-aged adults (n = 62,= 53.2 years), older adults (n = 65,= 81.5 years). …”

Supplementary material for cardiac responses to environmental heat exposure in young and older adults.docx by Josh Foster (21527189)

“…In both climates and in both age groups, heat stress <i>a)</i> increased cardiac output by ~0.7 ± 0.8 L/min, <i>b)</i> decreased stroke volume by ~7 <a href="" target="_blank">± </a>10 mL and <i>c)</i> augmented diastolic function through increased atrial contribution to filling by 5 ± 5%. …”

Dynamical properties of the kernel. by Mathias Foo (701966)

“…(D) The same <i>LHY</i> mRNA levels in (A), along with simulated <i>LHY</i> mRNA levels when <i>LHY/CCA1</i> inhibition by PRR5 (black dotted), or by PRR7 (gray dotted), or by both PRR5 and PRR7 (gray solid) was removed from MF2015. …”

Land Management Practices Associated with House Loss in Wildfires by Philip Gibbons (120631)

“…Significant fuel variables in a logistic regression model we selected to predict house loss were (in order of decreasing effect): (1) the cover of trees and shrubs within 40 m of houses, (2) whether trees and shrubs within 40 m of houses was predominantly remnant or planted, (3) the upwind distance from houses to groups of trees or shrubs, (4) the upwind distance from houses to public forested land (irrespective of whether it was managed for nature conservation or logging), (5) the upwind distance from houses to prescribed burning within 5 years, and (6) the number of buildings or structures within 40 m of houses. …”

Short-term time-restricted feeding during the resting phase is sufficient to induce leptin resistance that contributes to development of obesity and metabolic disorders in mice by Katsutaka Oishi (278169)

DataSheet1_Compounds Isolated from Wikstroemia taiwanensis Regulate Bone Remodeling by Modulating Osteoblast and Osteoclast Activities.docx by Zuha Imtiyaz (11119893)

“…Specifically, astragalin (1) and kaempferol 3-O-β-D-apiofuranosyl-(1→6)-β-D-glucopyranoside (2), besides increasing mineral deposition, increased alkaline phosphatase activity (137.2% for 1 and 115.8% for 2) and ESR-α expression (112.8% for 1 and 122.5% for 2) in primary human osteoblasts. In contrast, compounds 1, 2, 3, and 5 inhibited tartrate-resistant acid phosphatase (TRAP) activity in receptor activator of nuclear factor-κB ligand-induced osteoclasts by 40.8, 17.1, 25.9, and 14.5% and also decreased the number of TRAP-positive cells by 51.6, 26.8, 20.5, and 18.6%, respectively. …”

DataSheet1_Compounds Isolated from Wikstroemia taiwanensisRegulate Bone Remodeling by Modulating Osteoblast and Osteoclast Activities.docx by Zuha Imtiyaz (11119893)

“…Specifically, astragalin (1) and kaempferol 3-O-β-D-apiofuranosyl-(1→6)-β-D-glucopyranoside (2), besides increasing mineral deposition, increased alkaline phosphatase activity (137.2% for 1 and 115.8% for 2) and ESR-α expression (112.8% for 1 and 122.5% for 2) in primary human osteoblasts. In contrast, compounds 1, 2, 3, and 5 inhibited tartrate-resistant acid phosphatase (TRAP) activity in receptor activator of nuclear factor-κB ligand-induced osteoclasts by 40.8, 17.1, 25.9, and 14.5% and also decreased the number of TRAP-positive cells by 51.6, 26.8, 20.5, and 18.6%, respectively. …”

Table_1_Maternal Serotonin Reuptake Inhibitor Antidepressants Have Acute Effects on Fetal Heart Rate Variability in Late Gestation.docx by Kayleigh S. J. Campbell (11276013)

“…</p><p>Methods: At 36-weeks' gestation, cardiotocograph measures of fetal HR and HRV were obtained from 148 pregnant women [four groups: SRI-Depressed (n = 31), SRI-Non-Depressed (n = 18), Depressed (unmedicated; n = 42), and Control (n = 57)] before, and ~5-h after, typical SRI dose. Maternal plasma drug concentrations were quantified at baseline (pre-dose) and four time-points post-dose. …”

Decoder inferred using the extensive information model. by Kaushik J. Lakshminarasimhan (5782289)

“…Thresholds are shown for a population of 256 neurons, by which point the performance had saturated to its asymptotic value for all <i>γ</i>. …”