Combined treatment of CAPE with chemotherapy drugs shows synergistic and antagonistic inhibition on proliferation of PC-3 cells. by Hui-Ping Lin (184894)

“…<p>Proliferation of PC-3 cells treated with increasing dosage (0, 5, 10, 20 µM) of CAPE in combination with increasing concentration of etoposide (A), paclitaxol (B), vinblastine (C), mitoxantrone (D), and estramustine (E) for 72 h was determined by 96-well proliferation assay. …”

Body temperature, bioenergetic, and behavioral responses to acute hyperpurinergia. by Zarazuela Zolkipli-Cunningham (5234186)

“…<p>A. Male C57BL/6J mice (nucleotide dose = 0.5 μmol/g body weight, n = 6 per group, 5–6 months old), B. …”

Changes in volume, mass, and end-diastolic strain during experimental MR in dogs. by Johane H. Bracamonte (12883844)

“…<p>a) Fitted data on fold changes show a) a 36% increase in LVM [<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1012390#pcbi.1012390.ref015" target="_blank">15</a>,<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1012390#pcbi.1012390.ref016" target="_blank">16</a>,<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1012390#pcbi.1012390.ref020" target="_blank">20</a>–<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1012390#pcbi.1012390.ref033" target="_blank">33</a>] and b) 67% increase in LV end-diastolic volume (V_<i>ED</i>) [<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1012390#pcbi.1012390.ref016" target="_blank">16</a>,<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1012390#pcbi.1012390.ref017" target="_blank">17</a>,<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1012390#pcbi.1012390.ref020" target="_blank">20</a>–<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1012390#pcbi.1012390.ref026" target="_blank">26</a>,<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1012390#pcbi.1012390.ref029" target="_blank">29</a>,<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1012390#pcbi.1012390.ref032" target="_blank">32</a>,<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1012390#pcbi.1012390.ref033" target="_blank">33</a>,<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1012390#pcbi.1012390.ref061" target="_blank">61</a>,<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1012390#pcbi.1012390.ref078" target="_blank">78</a>,<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1012390#pcbi.1012390.ref080" target="_blank">80</a>,<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1012390#pcbi.1012390.ref082" target="_blank">82</a>,<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1012390#pcbi.1012390.ref083" target="_blank">83</a>,<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1012390#pcbi.1012390.ref131" target="_blank">131</a>–<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1012390#pcbi.1012390.ref136" target="_blank">136</a>] on average at steady-state. c) In a spherical model, these changes imply a 20% increase followed by a gradual decrease below baseline in end-diastolic strain on average, with a wide range of trajectories possible for different combinations of mass and volume change. d) Calculated chronic strain levels are lower when LVM increases more. …”

Long term follow up of biomarkers of podocyte damage and renal function in patients with and without preeclampsia by Ylbe Palacios de Franco (5254832)

“…Proteinuria decreased from 123.5 mg/g [65.9, 194.8] to 43.2 mg/g [20.9, 139.3], p = 0.12. …”

Long term follow up of biomarkers of podocyte damage and renal function in patients with and without preeclampsia by Ylbe Palacios de Franco (5254832)

“…Proteinuria decreased from 123.5 mg/g [65.9, 194.8] to 43.2 mg/g [20.9, 139.3], p = 0.12. …”

CTR-C PDZ- binding motif mutation and TJ disruption and invasion. by Ahmed Aljameeli (2548528)

“…<p>A. Transepithelial Electric Resistance (TER): Polarized PC-3v, PC-3-CTRwt and PC-3CTR-∆ESS cells were serum-starved for 4 hours, then treated with/without 50 nM CT. …”

Illustration of real and virtual objects in the Distance-discrimination control experiment. by Melina Heinrich (405120)

“…Thus, the virtual object appears behind the speaker-microphone combination at a distance of 204 cm. The bats were trained to discriminate a distance difference of 17 cm, as indicated by the vertical bars (RO: −8.5 cm; UO: +8.5 cm). …”

Figure 4 from ATF6 Promotes Colorectal Cancer Growth and Stemness by Regulating the Wnt Pathway by Jeffrey J. Rodvold (19921112)

“…<b>B,</b> Gene expression of CCK81 shATF6 cells as treated and analyzed in <b>A</b> (<i>n</i> = 3). <b>C,</b> Effect of ATF6 knockdown on LGR5 surface expression. …”

The NAD⁺ that is spontaneously released from M-MSNs@NAD⁺ can not increase the intracellular NAD⁺ and ATP levels in H₂O₂-treat... by Heyu Chen (456225)

“…<p>(A) The concentration of NAD⁺ that was spontaneously released from the 50 µg/mL M-MSNs@NAD⁺ into the media. …”

<i>In vitro</i> and <i>in vivo</i> cytotoxicity assessment of glyphosate and imazethapyr-based herbicides and their association by Gessyca Costa (12115178)

“…Data demonstrated cytotoxicity due to exposure to ATN, IMZT for both models, as follows: (1) ATN (0.5 mg/L), IMZT (5 mg/L), and M3 (0.05 mg/L ATN + 5 mg/L IMZT) increased cytotoxicity by disturbing the mitochondrial activity of HepG₂ cells 24 hr after exposure; (2) ATN and IMZT (5 mg/L), and M3 (0.05 mg/L ATN + 5 mg/L IMZT) also decreased the integrity of the membrane of HepG₂ cells after 24 hr incubation; (3) only ATN and IMZT (5 mg/L) in their single forms diminished the mitochondrial potential of zebrafish; (4) ATN (single form) at 0.5 mg/L induced apoptosis in zebrafish larvae. …”

Arf6 recruits the Rac GEF Kalirin to the plasma membrane facilitating Rac activation-0 by Tae Hyeon Koo (77248)

Hemodynamic effects of high-dose ephedrine in anesthetized rats. by Daniel Radiloff (588253)

“…C: Repeated injection of combined ephedrine (20 mg/kg) and ambrisentan (0.1 mg/kg) significantly enhances heart rates, and concomitantly, pulmonary blood flow, measured by pulmonary window blood flow measurements, and pulse oximetry (paired T-test, corrected for multiple comparison, p<0.05, N = 5). D: injection of ephedrine, alone or in combination with ambrisentan, caused a significant increase of breathing rates (one-sided ANOVA with Bonferroni correction, p<0.001, N = 5–13/group). …”

DataSheet_1_Appropriate pre-transplant strategy for patients with myelodysplastic syndromes receiving allogeneic haematopoietic stem cell transplantation after myeloablative condit... by Hong Wang (13528)

“…However, compared with patients who received HMA, those who received chemotherapy-based therapy had a lower 5-year OS rate (56% vs. 69%, P=0.020) and a slightly higher 5-year NRM rate (28% vs. 18%, P=0.067). …”

Fpr agonist activity in the skin wound. by Mingyong Liu (387689)

“…Neutrophils from WT mice were pretreated with Boc-1 (4 µM and 8 µM, <i>A</i>), WRW4 (4 µM and 8 µM, <i>B</i>) or Boc-2 (5 µM and 10 µM, <i>C</i>) for 30 min and then were measured for chemotaxis in response to homogenates of wounded skin collected at 4 h. *, significantly decreased number of migrating cells treated with Fpr antagonists as compared to neutrophils without pretreatment (<i>p</i>< 0.05). #, significantly decreased number of migrating cells treated with Fpr antagonists as compared to neutrophils without pretreatment (<i>p</i>< 0.05). …”

Data_Sheet_1_Identification of the Methanogenesis Inhibition Mechanism Using Comparative Analysis of Mathematical Models.pdf by Magela Odriozola (6677918)

“…The assessed inhibition models were: competitive (M1a), non-competitive (M2a), un-competitive (M3a), biocide-linear (M4a), and biocide-exponential (M5a). …”

Effects of Klf4-knockout on cell death and/or cell proliferation in the developing cerebellum. by Peter Zhang (777400)

“…The appearance of heterochromatic cells is a hallmark of the Klf4-null EGL compared to the wildtype at E15.5 (black arrows). …”

The simulation results for ratio of co-localization in flattened and spherical nucleus. by Jing Kang (251503)

“…(<b>B</b>) The co-localization ratio is a decreasing function of the number of transcription factors for both flattened nucleus of the same volume as the spherical one, and the nucleus of 5 times larger volume. …”

Gene numbers associated with differential expression in adipose and grouped for QTL position. by Nicholas M. Morton (206471)

“…The number in parenthesis indicates the number of genes within a QTL <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0023944#pone.0023944-Horvat1" target="_blank">[5]</a> as a percentage of the whole (genome wide column).…”

ECG reverts to normal sinus rhythm following resuscitation. by William P. Schilling (7522238)

“…PR interval was: (a) 27.5±0.8, (d) 32±1.1, (e) 27.8 ± 0.5 msec.</p>…”

Heatmap showing the frequencies of the historical and outbreak haplotypes at 11 inversion sites for all samples. by Monica K. Borucki (106008)

“…All entries of zero frequency were set to a floor of 10⁻⁵ so that they correspond to a valid logarithm value of -5 (dark green). …”