Data_Sheet_1_An RORγt Oral Inhibitor Modulates IL-17 Responses in Peripheral Blood and Intestinal Mucosa of Crohn's Disease Patients.docx by Helena Bassolas-Molina (5877569)

“…BI119 has a more profound effect in ileal CD with additional significant downregulation of IL23R, CSF2, CXCL1, CXCL8, and S100A8, and upregulation of DEFA5. …”

Table1_Clinical Evidence-Guided Anti-rheumatoid Arthritis Study of Shuji Tablet in Adjuvant-Induced Arthritis Rats and Mechanism Exploration via Network Pharmacological Approach.XL... by Weibo Dai (11201244)

“…The mechanism exploration and target prediction of SJT against RA were performed via a network pharmacological approach.</p><p>Results: SJT showed excellent alleviation on AIA rats, with evidence of reducing paws swelling, decreasing systemic symptoms score, and arthritis index. …”

DataSheet1_On-Site Deployment of an Air-Liquid-Interphase Device to Assess Health Hazard Potency of Airborne Workplace Contaminants: The Case of 3-D Printers.docx by Boowook Kim (780726)

“…Hyperspectral microscopic observation showed that 3-D printers emitted particles to be attached to A549 cells after 2-h exposure, and many particles were internalized by A549 cells after 24 h of post-exposure incubation. …”

Modifying FA metabolism alters pro-inflammatory cytokine expression in PHN. by Joseph W. McFadden (679148)

“…<p>(A) C75 reversed C16:0-induced mRNA expression for TNFα and IL1β, and potentiated C16:0-induced expression of IL6. …”

Biochemical data. by Abdallah Tageldein Mansour (21158819)

“…Therefore, this approach aimed to enhance PPE’s stability and bioavailability and investigate mitigating impact of pomegranate peel extract-loaded nanoparticles (PPE-NPs) in a colitis model. Colonic injury was induced by 5% dextran sulfate sodium (DSS) and efficacy of disease progression after oral administration of PPE-NPs for 14 days was assessed by evaluating clinical signs severity, antioxidant and inflammatory markers, expressions of endoplasmic reticulum associated genes and histopathological and immunostaining analysis in colonic tissues. …”

Scoring of Disease Activity Index (DAI). by Abdallah Tageldein Mansour (21158819)

“…Therefore, this approach aimed to enhance PPE’s stability and bioavailability and investigate mitigating impact of pomegranate peel extract-loaded nanoparticles (PPE-NPs) in a colitis model. Colonic injury was induced by 5% dextran sulfate sodium (DSS) and efficacy of disease progression after oral administration of PPE-NPs for 14 days was assessed by evaluating clinical signs severity, antioxidant and inflammatory markers, expressions of endoplasmic reticulum associated genes and histopathological and immunostaining analysis in colonic tissues. …”

Primers sequences used in this study. by Abdallah Tageldein Mansour (21158819)

“…Therefore, this approach aimed to enhance PPE’s stability and bioavailability and investigate mitigating impact of pomegranate peel extract-loaded nanoparticles (PPE-NPs) in a colitis model. Colonic injury was induced by 5% dextran sulfate sodium (DSS) and efficacy of disease progression after oral administration of PPE-NPs for 14 days was assessed by evaluating clinical signs severity, antioxidant and inflammatory markers, expressions of endoplasmic reticulum associated genes and histopathological and immunostaining analysis in colonic tissues. …”

Analysis of the interplay between MeCP2 and histone H1 during <i>in vitro</i> differentiation of human ReNCell neural progenitor cells by Edilene Siqueira (17742491)

“…ReNCell expressed minimal amounts of histone H1.0 and their linker histone complement consisted mainly of histone H1.2, H1.4 and H1.5. The overall level of histone H1 exhibited a trend to increase during the differentiation of MeCP2 KO cells. …”

Pentoxifylline, dexamethasone and azithromycin demonstrate distinct age-dependent and synergistic inhibition of TLR- and inflammasome-mediated cytokine production in human newborn... by Esther M. Speer (5158913)

“…<div><p>Introduction</p><p>Neonatal inflammation, mediated in part through Toll-like receptor (TLR) and inflammasome signaling, contributes to adverse outcomes including organ injury. Pentoxifylline (PTX), a phosphodiesterase inhibitor which potently suppresses cytokine production in newborn cord blood, is a candidate neonatal anti-inflammatory agent. …”

Data_Sheet_1_Non-linear connections between maternal hemoglobin during the third trimester of pregnancy and birth weight outcomes in full-term newborns: Estimating the breakpoints.... by Guilan Xie (9330171)

“…There was an increasing trend of the risk of LBW and a decreased trend of LGA with the increase in maternal hemoglobin concentration. …”

Data Sheet 1_Effect of Fangxia-Dihuang Decoction on doxorubicin-induced cognitive impairment in breast cancer animal model.docx by Xuan Wang (55634)

“…</p>Methods<p>Build 4T1 breast cancer xenograft tumor model in Balb/c mice, intraperitoneal injection of DOX (5mg/kg) once a week, build the model of DOX induced chemotherapy related cognitive impairment (CRCI), and the administration lasted for three weeks. …”

Image_1_Trend and early outcomes in isolated surgical aortic valve replacement in the United Kingdom.pdf by Jeremy Chan (14348490)

“…The in-hospital/30-day mortality rate decreased from 5.28% (1996) to 1.06% (2018), despite an increasing trend in EuroSCORE II. …”

Image1_Arbuscular mycorrhizal fungi alleviate Mn phytotoxicity by altering Mn subcellular distribution and chemical forms in Lespedeza davidii.tif by Gao Pan (12510447)

“…</p>Methods<p>In this study, Lespedeza davidii inoculated with or without AMF (Glomus mosseae) under different Mn concentrations (0 mmol/L, 1 mmol/L, 5 mmol/L, 10 mmol/L, and 20 mmol/L) was cultivated via a pot experiment, and plant biomass, physiological and biochemical characteristics, manganese absorption, subcellular distribution, and chemical forms of Mn were examined.…”

Binary mixing of lithospheric mantle and asthenosphere beneath Tengchong volcano, SE Tibet: evidence from noble gas isotopic signatures by Kefei Chen (24659)

“…These observations indicate that the primitive magmas originated from a mixture of metasomatized SCLM and enriched asthenospheric mantle. …”

Image_2_Protective Effects of Bariatric Surgery on Kidney Functions by Inhibiting Oxidative Stress Responses Through Activating PPARα in Rats With Diabetes.tif by Hong-Wei Jiang (11035041)

“…</p>Methods<p>We established a useful type 2 diabetic rat model using high-fat and high-sugar diet feeding following low-dose streptozotocin (STZ) treatment. …”

<i>VHL-KO</i> mice exhibit hypoglycemia despite normal glucose tolerance and intact pancreatic β cells. by Atsushi Kurabayashi (156793)

“…<p>(<b>A</b>) <i>VHL-KO</i> mice had significant decreases in blood glucose levels (BS) after tamoxifen injection (4 mg/mouse; n = 10). …”

<b>CRTC1 in Mc4r-expressing cells is required for peripheral metabolism and systemic energy homeostasis</b> by Haruka Miyamori (11938689)

“…In this study, mice with CRTC1 deficiency in Mc4r-expressing cells exhibited 1) modest obesity, glucose intolerance, insulin resistance, hyperinsulinemia, and hyperlipidemia; 2) decreased systemic energy expenditure and thermogenesis; 3) suppression of melanocortin agonist-induced adaptation of energy expenditure and food intake; 4) impaired thermogenic programs and oxidative pathway in brown adipose tissue and skeletal muscle; and 5) enhanced lipogenic programs in the liver and white adipose tissue. …”

Image_3_Protective Effects of Bariatric Surgery on Kidney Functions by Inhibiting Oxidative Stress Responses Through Activating PPARα in Rats With Diabetes.tif by Hong-Wei Jiang (11035041)

“…</p>Methods<p>We established a useful type 2 diabetic rat model using high-fat and high-sugar diet feeding following low-dose streptozotocin (STZ) treatment. …”

Data Sheet 1_Neonatal body composition, salivary feeding gene expression, and feeding outcomes in infants of diabetic mothers.csv by Dara Azuma (20452160)

“…Introduction<p>Infants of diabetic mothers (IDMs) may exhibit decreased oral intake, requiring nasogastric feedings and prolonged hospitalization. …”

Sustained JNK pathway phosphorylation by TNF-α in NF-κB-inhibited RPE cells. by Hiroto Terasaki (104937)

“…<p>A: Western blot analysis of polarized RPE cells for phospho-c-Jun, phospho-JNK, and phospho NF-κB p65. …”