Discovery of a Novel Class of d‑Amino Acid Oxidase Inhibitors Using the Schrödinger Computational Platform by Haifeng Tang (488592)

“…d-Serine is a coagonist of the <i>N</i>-methyl d-aspartate (NMDA) receptor, a key excitatory neurotransmitter receptor. …”

13C-NMR fitting of M0 (a), M1 (b), M2 (c). by Shufeng Zhao (12820875)

vFLIP maintains intestinal barrier integrity in a short term model <i>in vivo</i>. by Barbara Ruder (8379354)

Discovery of a Novel Class of d‑Amino Acid Oxidase Inhibitors Using the Schrödinger Computational Platform by Haifeng Tang (488592)

“…d-Serine is a coagonist of the <i>N</i>-methyl d-aspartate (NMDA) receptor, a key excitatory neurotransmitter receptor. …”

Composition (%) and gross chemical content (g/kg as fed) of the piglets experimental diets^a. by M. Girard (8501361)

Frontier analysis findings: (A) A frontier analysis diagram based on Age-Standardized DALYs Rate (ASDR) and the SDI from 1990 to 2021. by Guanghui Yu (423945)

Luminal tumors have a deregulated sphingolipid and ganglioside profile and high RICTOR expression. by Mohammad Nafees Ansari (22232505)

“…(<b>D</b>–<b>H</b>) Absolute quantification (mean ± SEM, <i>n</i> = 5) of GM3 (D), GD3 (E), GD2 (F), GM2 (G), and GM1 (H) gangliosides in luminal tumor tissues and adjacent normal tissues shows an increase in GM3 and GD3 gangliosides and a decrease in GM1 gangliosides in luminal tumor tissues. …”

Blocking the A_2B adenosine receptor alleviates myocardial damage by inhibiting spleen-derived MDSC mobilisation after acute myocardial infarction by Zongying Yu (10052796)

“…In AMI model mice, the percentage of MDSCs was increased in the circulation and infarcted heart and decreased in the spleen. MRS-1754-mediated A_2BAR inhibition decreased the MDSC ratio in the circulation and infarcted heart and prevented the decrease in MDSC number in the spleens of mice with AMI. …”

Potential pathways of lithium action on autophagy and GFAP expression. by Christine M. LaPash Daniels (796881)

“…Disinhibition of mTOR can then lead to a decrease in autophagy. Lithium can also increase autophagy through the IMPase pathway. …”

LiCl administered via 0.5% LiCl food pellets for 4 wks decreases the antioxidant stress response. by Christine M. LaPash Daniels (796881)

“…<p>(A) LiCl decreases <i>Nrf2</i> transcripts in hippocampus and cortex of R236H/+ mice (N = 5 male mice per group). …”

Meta-analysis for ever smoking and risk of A) all-cause dementia, B) Alzheimer’s disease and C) vascular dementia. by Guochao Zhong (701289)

Smoking Is Associated with an Increased Risk of Dementia: A Meta-Analysis of Prospective Cohort Studies with Investigation of Potential Effect Modifiers by Guochao Zhong (701289)

“…<div><p>Background</p><p>Previous studies showed inconsistent results on the association of smoking with all-cause dementia and vascular dementia (VaD), and are limited by inclusion of a small number of studies and unexplained heterogeneity. …”

Meta-analysis for former smoking and risk of A) all-cause dementia, B) Alzheimer’s disease and C) vascular dementia. by Guochao Zhong (701289)

Meta-analysis for current smoking and risk of A) all-cause dementia, B) Alzheimer’s disease and C) vascular dementia. by Guochao Zhong (701289)

Effect of extended-release buprenorphine (1 mg/kg, SC) vs. saline on the acute thermal nociception in naïve rats, quantified by tail flick assay in 52.5°C warm water bath. by Christina M. Larson (18196213)

[Ca²⁺]_cyt -dynamics in A. thaliana YC3.6 seedlings in response to DMBQ. by Alexandra W. Fuller (849994)

LiCl administered via 0.5% LiCl food pellets for 8 wks decreases GFAP levels in surviving <i>Gfap</i>-R236H/+ mice. by Christine M. LaPash Daniels (796881)

“…<p>(A) 81.8% (9/11) +/+ mice and 54.5% (6/11) R236H/+ mice survived 8 wks of LiCl treatment. …”

LiCl administered via 0.5% LiCl food pellets for 4 wks decreases GFAP levels in <i>Gfap</i>-R236H/+ mice. by Christine M. LaPash Daniels (796881)

“…<p>(A) Survival analysis for mice treated with 0.5% LiCl in food pellets for 4 wks. 94.7% (36/38) R236H/+ mice survived LiCl treatment while 100% of mice in other groups survived. …”

Concentric joint work data from the lower limb joints. by Eric Yung-Sheng Su (13015474)

Eccentric joint work data from the lower limb joints. by Eric Yung-Sheng Su (13015474)