A high-throughput screening identifies ZNF418 as a novel regulator of the ubiquitin-proteasome system and autophagy-lysosomal pathway by Sonia R Singh (9704338)

“…We undertook an unbiased, total genome high-throughput screen to identify novel effectors that regulate both the UPS and ALP. We generated a stable HEK293 cell line expressing a UPS reporter (Ub^G76V-mCherry) and an ALP reporter (GFP-LC3) and screened for genes for which knockdown increased both Ub^G76V-mCherry intensity and GFP-LC3 puncta. …”

Kit-mediated autophagy suppression driven by a viral oncoprotein emerges as a crucial survival mechanism in Merkel cell carcinoma by Hao Shi (158171)

“…Thus, autophagy-inducing agents represent a therapeutic strategy in advanced MCPyV-associated MCC.…”

Table_1_The effect of a community-based group intervention on chronic disease self-management in a vulnerable population.docx by Sophie A. Korenhof (16856631)

“…For caregivers without a chronic condition, only doctor visits significantly decreased (1.54 vs. 2.25, P < 0.001).…”

Histology of the myocardium and WAT of mice during acute infection (n = 5, minimum five images/section were analyzed). by Fnu Nagajyothi (37087)

“…A dramatic decrease in the severity of the infection (the sum of grading) was observed in the hearts of HFD-fed mice (5.2±0.815) compared with RD fed mice (13±1.367). …”

Decrease in numbers of <i>Tph2</i>- and <i>Sert</i>-labeled neurons in the dorsal raphe nucleus (DR) and raphe magnus nucleus (RMg). by Ning-Ning Song (233637)

“…<p>The number of neurons with intense <i>in situ</i> signals of <i>Tph2</i> and <i>Sert</i> are significantly decreased in the DR (A) and RMg (B) of <i>Lmx1b</i> iCKO mice (n = 4; * <i>P</i><0.05), while the number of <i>Aadc</i> positive cell is comparable in <i>Lmx1b</i> iCKO mice and wild-type mice (n = 4, <i>P</i>>0.5).…”

The double blind, placebo-controlled, dose-escalating, multiple-dose study: Arms, subject enrollment, disposition, and analysis. by Deepti Saxena (462177)

“…Subjects are indicated by number and were dichotomized after one week on-drug (S1) into those who did achieve the threshold of ≥150 μM in serum (Group A) or who did not (Group B [≤149 μM] and Group C [‘below the threshold, unaffected by medication’]) (see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0154842#pone.0154842.g007" target="_blank">Fig 7</a>); and after 8 weeks off-drug (S2) into those who had or who had not shown a S1 viral response (see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0154842#pone.0154842.g008" target="_blank">Fig 8</a>). …”

Analysis of covariance for BMO-MRW (a), RNFL (inner, b; middle, c; outer, d), and GCL (e) considering age and patients’ groups. by Bettina Hohberger (4542781)

“…<p>(a) a significant age effect on BMO-MRW was observed (p = 0.047); (b-d) age showed an impact on RFNL for the inner and middle scan; gender was significantly associated with RNFL of the outer scan; (e) a significant decrease of RGC was observed with increasing age for male and female persons (p = 0.0021).…”

Effect of 1.25% SCFP on poultry cecal microbial composition inoculated with six multidrug-resistant (<i>MDR</i>) <i>Salmonella</i> serovars compared to a no-treatment control at 24... by Elena G. Olson (10649705)

Inhibition of integrin β3 during the process of virus entering in the midgut epithelial cells decrease the relative mRNA level of <i>Atgs</i>. by Lu Zhang (50563)

CMZ prevented the decrease of protein levels of PPAR-α, p300 and Sirt-1, and inhibited the increased acetylation of PGC-1α induced by ethanol. by Tao Zeng (103451)

Real herbicide wastewater treatment by combined means of electrocatalysis application and biological treatment by Liman Zhang (204829)

“…The results indicated that COD removal ratio reached 87.0%, and the COD decreased from 7519 mg L⁻¹ to 980 mg L⁻¹ after 120 min electrolysis under the degradation parameters of the current density of 4 a dm⁻², pH value of 4 and the plate spacing of 1.0 cm. …”

Rabbit ATG and alemtuzumab decrease effector mechanisms of peripheral blood CD3⁻CD56^dim NK cells. by Diana Stauch (266579)

“…<p>(A) Dose-dependent decrease of NK cell cytotoxicity after 18 hours pretreatment with rATG, alemtuzumab, daclizumab and rIgG (0–100 µg). …”

Characteristics of patients with AKI diagnosed using KDIGO definition versus patients diagnosed with AKI by eKDIGO only by the decrease in sCr (deKDIGO). by Marina Wainstein (12437091)

Emotions. by Teresa Gavaruzzi (5464847)

Heart rate. by Teresa Gavaruzzi (5464847)

“…<p>HR decreases during narrative reading as a function of narrative content.…”

Intention. by Teresa Gavaruzzi (5464847)

Table_1_Exposure to Olfactory Alcohol Cues During Non-rapid Eye Movement Sleep Did Not Decrease Craving in Patients With Alcohol Dependence.pdf by Ran Zhu (2463547)

Corrugator EMG. by Teresa Gavaruzzi (5464847)

Abundance of (A) <i>Escherichia coli</i> and coliforms (excluding <i>E</i>. <i>coli</i>), and (B) <i>β</i>-lactam-resistant <i>E</i>. <i>coli</i> and <i>β</i>-lactam-resistant coli... by Akira Fukuda (682800)

Switching the Adhesive State of Catecholic Hydrogels using Phototitration by Evan M. White (1879558)

“…Irradiation of these hydrogels with UV light affords a viscous liquid solution, demonstrating a gel–sol transition with a subsequent decrease in the adhesive strength of the material. …”