Cell-intrinsic sphingosine kinase 2 promotes macrophage polarization and renal inflammation in response to unilateral ureteral obstruction by Mallika Ghosh (742901)

“…These results demonstrate that reducing Sphk2 activity by genetic or pharmacological manipulation markedly decreases inflammatory and fibrotic responses to obstruction, resulting in diminished renal injury and supporting Sphk2 as a novel driver of the pro-inflammatory macrophage phenotype.…”

Prediction of Retention Time and Collision Cross Section (CCS_H+, CCS_H–, and CCS_Na+) of Emerging Contaminants Using Multiple Adaptive Regression Spl... by Alberto Celma (4092583)

“…Multivariate and univariate models were evaluated showing a better fit for univariate models to the experimental data. …”

Table_1_Supplemental Xylooligosaccharide Modulates Intestinal Mucosal Barrier and Cecal Microbiota in Laying Hens Fed Oxidized Fish Oil.DOCX by Jian-min Zhou (10175516)

“…The abundance of Erysipelatoclostridium decreased by XOS addition was negatively associated with ileal VH, VCR, ileal mucosal sIgA content, and the relative expression of zonula occludens-2, CLDN1, and CLDN5. …”

Exploiting Co-Benefits of Increased Rice Production and Reduced Greenhouse Gas Emission through Optimized Crop and Soil Management by Ning An (618997)

“…Advances in nitrogen, water and crop management (Best Management Practices—BMPs) helped closing existing yield gaps and resulted in a substantial reduction in CO₂-equivalent emission of rice farming despite a tradeoff of increase N₂O emission. …”

Epigenetic regulatory genes as putative cancer amplified driver genes. by Ying Chen (9697)

“…(B) <i>BRD4</i> and <i>YEATS4</i> shRNA activity in a panel of cancer cell lines (Project Achilles). shRNA score denotes the log2 based decrease in the representative shRNA compared to pooled shRNA in cancer cell lines after several rounds of proliferation post-shRNA <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0098293#pone.0098293-Cheung1" target="_blank">[11]</a>. …”

Table_4_Long Non-coding RNAs Rian and Miat Mediate Myofibroblast Formation in Kidney Fibrosis.xlsx by Roel Bijkerk (4662769)

“…In order to identify pericyte long non-coding RNAs (lncRNAs) that could serve as a target to decrease myofibroblast formation and counteract the progression of kidney fibrosis we employed two models of experimental kidney injury, one focused on kidney fibrosis (unilateral ureteral obstruction; UUO), and one focused on acute kidney injury that yields kidney fibrosis in the longer term (unilateral ischemia-reperfusion injury; IRI). …”

Reliable and robust method for abdominal muscle mass quantification using CT/MRI: An explorative study in healthy subjects by Jisuk Park (7405823)

“…In terms of the measurement level, TAMA did not differ from the L2_inf to L4_inf levels, whereas TPA increased with a decrease in measurement level.</p><p>Conclusions</p><p>TAMA is a better biomarker than TPA in terms of inter-scan and inter-reader agreement and robustness to the measurement level. …”

Data_Sheet_3_Generation and Validation of miR-100 Hepatocyte-Specific Knock-Out Mice.PDF by Dong Yang (141041)

“…<p>Background: Inactivation of microRNA-100 (miR-100) is involved in hepatocellular carcinoma (HCC) and miR-100 behaves as a tumor suppressor. To understand miR-100 function in HCC genesis and development in vivo, we developed hepatocyte-specific miR-100 deficient mice.…”

Image_2_Resting Heart Rate Variability Is Associated With Subsequent Orthostatic Hypotension: Comparison Between Healthy Older People and Patients With Rapid Eye Movement Sleep Beh... by Yukiyoshi Sumi (5290874)

“…The orthostatic challenge test is a standard autonomic function test that measures a decrease of blood pressure during a postural change from supine to standing positions. …”

Image_1_Resting Heart Rate Variability Is Associated With Subsequent Orthostatic Hypotension: Comparison Between Healthy Older People and Patients With Rapid Eye Movement Sleep Beh... by Yukiyoshi Sumi (5290874)

“…The orthostatic challenge test is a standard autonomic function test that measures a decrease of blood pressure during a postural change from supine to standing positions. …”

DataSheet1_Lysosomal TRPML1 triggers global Ca2+ signals and nitric oxide release in human cerebrovascular endothelial cells.docx by Valentina Brunetti (18861187)

“…Notably, interfering with TRPML1-mediated lysosomal Ca²⁺ mobilization led to a decrease in the free ER Ca²⁺ concentration. …”

DataSheet1_Characteristics of adverse reactions of three anti-glioma drugs in WHO-VigiAccess.ZIP by Huadong Ke (19937268)

“…The analysis revealed that the ten most frequently reported AEs included bone marrow suppression, myalgia, leukopenia, thrombocytopenia, nausea, vomiting, death, rhabdomyolysis, disease progression, and a decrease in neutrophil count. The five most common categories of AEs related to anti-glioma drugs were blood and lymphatic system diseases (20,233 cases, 15.2%), general disorders and administration site conditions (26,973 cases, 20.3%), gastrointestinal dysfunction (22,061 cases, 16.7%), necessitating further investigations (18,285 cases, 13.8%), and musculoskeletal and connective tissue diseases (30,695 cases, 23.1%). …”

Image_3_Microbial Community Redundancy and Resilience Underpins High-Rate Anaerobic Treatment of Dairy-Processing Wastewater at Ambient Temperatures.TIF by Lara M. Paulo (8567841)

“…For example, the main pH shock led to a drop in the methane content to 15%, COD removals decreased to 0%, while the archaeal population decreased to ~11% both at DNA and cDNA levels. …”

Image_2_Genes related to osmoregulation and antioxidation play important roles in the response of Trollius chinensis seedlings to saline-alkali stress.jpg by Rongmiao Hou (14507159)

“…<p>Saline-alkali stress is one of the main abiotic stress factors affecting plant growth and development. Trollius chinensis is a perennial herbal medicinal plant with high values for garden application. …”

How Does Single Oxygen Atom Addition Affect the Properties of an Fe−Nitrile Hydratase Analogue? The Compensatory Role of the Unmodified Thiolate by Priscilla Lugo-Mas (2406259)

“…Nitrile hydratase (NHase) is one of a growing number of enzymes shown to contain post-translationally modified cysteine sulfenic acids (Cys-SOH). …”

Data_Sheet_8_Global, regional, and national burden of chronic respiratory diseases and associated risk factors, 1990–2019: Results from the Global Burden of Disease Study 2019.ZIP... by Xiang Chen (10398)

“…</p>Results<p>In 2019, 454.56 [95% uncertainty interval (UI): 417.35–499.14] million individuals worldwide had a CRD, showing a 39·8% increase compared with 1990. …”

Integrating temperature-dependent life table data into Insect Life Cycle Model for predicting the potential distribution of <i>Scapsipedus icipe</i> Hugel & Tanga by Magara H. J. Otieno (7430183)

“…<div><p><i>Scapsipedus icipe</i> Hugel and Tanga (Orthoptera: Gryllidae) is a newly described edible cricket species. Although, there is substantial interest in mass production of <i>S</i>. …”

Data_Sheet_3_Gene Co-expression Network Reveals Potential New Genes Related to Sugarcane Bagasse Degradation in Trichoderma reesei RUT-30.PDF by Gustavo Pagotto Borin (751443)

“…Our results demonstrate a vast range of new promising targets that merit additional studies to improve the cellulolytic potential of T. reesei strains and to decrease the production costs of 2G ethanol.…”

How Does Single Oxygen Atom Addition Affect the Properties of an Fe−Nitrile Hydratase Analogue? The Compensatory Role of the Unmodified Thiolate by Priscilla Lugo-Mas (2406259)

“…Nitrile hydratase (NHase) is one of a growing number of enzymes shown to contain post-translationally modified cysteine sulfenic acids (Cys-SOH). …”

Image_2_Warming and CO2 Enhance Arctic Heterotrophic Microbial Activity.tif by Dolors Vaqué (683567)

“…Results showed that chlorophyll a concentration decreased at increasing temperatures, while BP significantly increased with pCO₂ at 6 and 10°C. …”