Image1_Total flavonoids extracted from Penthorum chinense Pursh mitigates CCl4-induced hepatic fibrosis in rats via inactivation of TLR4-MyD88-mediated NF-κB pathways and regulatio... by Sujuan Wang (1865149)

“…Compared with control animals, CCl₄-treated rats demonstrated obvious liver injury and fibrosis, manifested as increases in gray values, distal diameter of portal vein (DDPV) and a decrease in blood flow velocity (VPV) in the ultrasound analysis; increased biochemical index values (serum levels of ALT, AST, TBIL, and ALP); marked increases in the contents of fibrotic markers (PC III, COL4, LN, HA) and inflammatory factors (serum TNF-α, IL-6, and IL-1β); and significant pathological changes. …”

Data Sheet 2_Cepharanthine may inhibit the proliferation of prostate cells by blocking the EGFR/PI3K/AKT signaling pathway: comprehensive network analysis, molecular docking, and e... by Yin Huang (179237)

“…Celigo counting revealed a significant decrease in both cell lines after 24–96 h of CEP treatment. …”

In vitro experiments yielded inconclusive results for predicting in vivo metastatic potential of L1CAM knockdown melanoma cells. by Ann-Kathrin Ernst (4846645)

“…Laminar flow adhesion assay on activated endothelium: Interactions of melanoma cells suspended in culture medium with a HUVEC monolayer under laminar flow. The number of events (only adherence and tethering, no rolling events) increased significantly for MeWo L1 kd against MeWo Luc cells and decreased significantly for MV3 L1 kd against MV3 Luc cells (E).…”

Effects of L’sc and Notch LoF and GoF on Ase expression. by Mercedes Martin (17271325)

“…Surface (E,F) and deep (G,H) views. The OPC of a <i>c820>Dl-DN</i> larvae exhibits a strong decrease of Ase expression in the medial L’sc⁺ neighboring cells (arrowheads) relative to the control. …”

Table_4_Systemic immunological profile of children with B-cell acute lymphoblastic leukemia: performance of cell populations and soluble mediators as serum biomarkers.docx by Maria Perpétuo Socorro Sampaio Carvalho (7300568)

“…On D8 and D15, the patients presented a transition in the immunological profile. While, on D35, they already presented an opposite profile to D0, with an increase in NKT, CD3⁺ T, CD4⁺ T and Treg cells, along with CCL5, and a decrease in the levels of CXCL9, CXCL10 and IL-10, thus demonstrating that B-ALL patients present a complex and dynamic immune network during induction therapy. …”

DataSheet4_Multi-omics analyses reveal ClpP activators disrupt essential mitochondrial pathways in triple-negative breast cancer.xlsx by Emily M. J. Fennell (6654536)

“…GO analysis of these data demonstrated additional similarity of response to ONC201 and TR-57, including a decrease in transcripts related to the mitochondrial inner membrane and matrix, cell cycle, and nucleus, and increases in other nuclear transcripts and transcripts related to metal-ion binding. …”

Baseline characteristics of patients. by Seung-Jae Joo (3620240)

“…After handgrip exercise, an increase in E_LVI (<i>P</i> = 0.021) and a decrease in VAC (<i>P</i> = 0.035) were observed specifically in men, with no corresponding changes noted in women. …”

Image5_Neuronal nitric oxide synthase required for erythropoietin modulation of heart function in mice.pdf by Jeeyoung Lee (2638744)

“…</p><p>Results: ΔEPORE mice showed a decrease in the left ventricular outflow tract (LVOT) peak velocity, ejection fraction, and fractional shortening, showing that endogenous non-erythroid EPO response is protective for heart function. …”

Point-of-care testing for <i>Toxoplasma gondii</i> IgG/IgM using <i>Toxoplasma</i> ICT IgG-IgM test with sera from the United States and implications for developing countries by Ian J. Begeman (4172935)

“…From the present study, it appears a simple, low-cost POC test is now available to help prevent morbidity/disability, decrease cost, and make gestational screening feasible. …”

Data_Sheet_1_Comparison of long-term cardiovascular and renal outcomes between percutaneous coronary intervention and coronary artery bypass grafting in multi-vessel disease with c... by Woochan Kwon (13772311)

“…However, PCI-CR had a comparable 5-year death, MI, or stroke rate to CABG (HR: 0.86, 95% CI 0.54–1.38, p = 0.54).…”

Data Sheet 1_Enabling immune checkpoint blockade efficacy in T-lymphopenia by restoring CD8 T cell dynamics with IL-7 cytokine therapy.docx by Yeon-Woo Kang (18285202)

“…Crucially, TLP led to a shift in the composition of tumor-infiltrating lymphocytes, with a decrease in PD-1⁺ tumor-reactive CD8 T cells and an increase in PD-1⁻ bystander cells. …”

Image2_Total flavonoids extracted from Penthorum chinense Pursh mitigates CCl4-induced hepatic fibrosis in rats via inactivation of TLR4-MyD88-mediated NF-κB pathways and regulatio... by Sujuan Wang (1865149)

“…Compared with control animals, CCl₄-treated rats demonstrated obvious liver injury and fibrosis, manifested as increases in gray values, distal diameter of portal vein (DDPV) and a decrease in blood flow velocity (VPV) in the ultrasound analysis; increased biochemical index values (serum levels of ALT, AST, TBIL, and ALP); marked increases in the contents of fibrotic markers (PC III, COL4, LN, HA) and inflammatory factors (serum TNF-α, IL-6, and IL-1β); and significant pathological changes. …”

Effects of forced Elf5 expression on tumor growth and cell autonomous pro-tumorigenic traits. by David Gallego-Ortega (107516)

“…<p><b>Panel A</b>, PyMT mammary tumors showing heterogeneous expression of ELF5 visualized by EGFP expression. …”

Surveillance of Avian H7N9 Virus in Various Environments of Zhejiang Province, China before and after Live Poultry Markets Were Closed in 2013–2014 by Xiaoxiao Wang (337498)

“…This corresponded with a decrease in the number of human H7N9 cases reported.…”

Table_1_NK Cell Subsets Changes in Partial Remission and Early Stages of Pediatric Type 1 Diabetes.docx by Laia Gomez-Muñoz (8054927)

“…Our results showed that total NK cells and their four subsets are altered at the early stages of T1D. A decrease in the counts and percentage of total NK cells and NK_eff cells at the different disease stages was found when compared to controls. …”

Patterns of astrocytic process coverage and vessel sprouting in the control and class II <i>orc3/hGFAP-cre</i> mutant cortices during early postnatal development. by Shang Ma (125139)

“…<p>(<b>A–C</b>) Astrocytic process coverage in the upper third of control cortices at P3 (<b>A</b>), P5 (<b>B</b>), and P7 (<b>C</b>). …”

Role of DNA methylation in expression control of the <i>IKZF3-GSDMA</i> region in human epithelial cells by Sanny Moussette (3797734)

“…Upregulation of <i>ZPBP2</i> and <i>GSDMA</i> was accompanied by a decrease in promoter methylation. Moreover, 5-aza-dC treatment modified allelic expression of <i>ZPBP2</i> and <i>ORMDL3</i> suggesting that different alleles may respond differently to treatment. …”

DataSheet_1_Cell-free DNA in patients with sepsis: long term trajectory and association with 28-day mortality and sepsis-associated acute kidney injury.docx by Sophie Dennhardt (5445479)

“…Considering that our data show that cfDNA levels decrease after the first insult, future studies could investigate cfDNA as a “memoryless” marker and thus bring further innovation to the complex field of SA-AKI diagnostics.…”

Table_2_Gegen Qinlian Decoction Coordinately Regulates PPARγ and PPARα to Improve Glucose and Lipid Homeostasis in Diabetic Rats and Insulin Resistance 3T3-L1 Adipocytes.docx by Jun Tu (802496)

“…<p>Gegen Qinlian Decoction (GQD), a well-documented traditional Chinese Medicine (TCM) formula, was reported with convincing anti-diabetic effects in clinical practice. …”

Image_1_Comparison of long-term cardiovascular and renal outcomes between percutaneous coronary intervention and coronary artery bypass grafting in multi-vessel disease with chroni... by Woochan Kwon (13772311)

“…However, PCI-CR had a comparable 5-year death, MI, or stroke rate to CABG (HR: 0.86, 95% CI 0.54–1.38, p = 0.54).…”