Exploiting the 2‑Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery by Pasquale Linciano (4426435)

“…In particular, compound <b>4m</b>, a biphenyl-thiadiazole-2,5-diamine with IC₅₀ = 16 μM, was able to potentiate the antitrypanosomal activity of the dihydrofolate reductase inhibitor methotrexate (MTX) with a 4.1-fold decrease of the EC₅₀ value. …”

Data_Sheet_1_Cuticular hydrocarbons of alpine bumble bees (Hymenoptera: Bombus) are species-specific, but show little evidence of elevation-related climate adaptation.PDF by Fabienne Maihoff (13170639)

“…We then analyzed intraspecific variation in CHCs of Bombus pascuorum along the elevational gradient and tested whether these traits respond to temperature. Finally, we used a field translocation experiment to test whether CHCs of Bombus lucorum workers change, when translocated from the foothill of a cool and wet mountain region to (a) higher elevations, and (b) a warm and dry region. …”

Image 1_Accrued reductions in heart rate following transcutaneous vagal nerve stimulation in adults with posttraumatic stress disorder.png by Srirakshaa Sundararaj (16945455)

“…Background<p>Post-Traumatic Stress Disorder (PTSD) is a condition marked by chronic autonomic dysregulation, including heightened arousal and increased heart rate, contributing to a higher risk of cardiovascular disease (CVD). tcVNS has been shown in prior work to decrease arousal and reduce heart rate in participants with PTSD during stimulation and 2–3 min afterward. …”

Image_1_Organ-Specific Gene Expression Reveals the Role of the Cymbidium ensifolium-miR396/Growth-Regulating Factors Module in Flower Development of the Orchid Plant Cymbidium ensi... by Fengxi Yang (428964)

“…We observed a significant decrease in the transcripts of several CeGRFs in flowers and leaves, indicating a potential role for miR396–GRF module in organ development through the cleavage of distinct CeGRFs. …”

Table2_Balancing welfare and habitat damage in pigs (Sus scrofa) under extensive farming: an ethological approach for determining the effects of group composition and environmental... by Edoardo Collarini (10146350)

“…In enrichment conditions with straw, we found a significant decrease in anxiety-related, affiliation, and excavation behaviours levels, and a significant increase in non-invasive exploration behaviours. …”

Data Sheet 1_Hochuekkito accelerates recovery from cisplatin induced-muscle atrophy accompanied by slow-twitch fiber-specific microRNA upregulation in mice.zip by Hitomi Sekine (12162830)

“…As muscle atrophy negatively impacts the prognosis and survival of cancer patients, elucidation of its pathogenesis and development of preventive and treatment methods is important. Hochuekkito (HET), a Japanese Kampo medicine, has been reported to improve decreased physical activity and muscle weight in various animal models, but not in cisplatin-induced muscle atrophy. …”

Image 2_Effect of dietary supplementation with Brevibacillus laterosporus on broiler growth performance, meat quality and gut microbiome.jpeg by Haixia Han (336363)

“…Specifically, the HBL group exhibited a notable increase in muscle C18:3n3 content, and a significant decrease in muscle C18:1n9t and C20:3n3 content. …”

Data_Sheet_1_Phenotyping and Quantitative Trait Locus Analysis for the Limited Transpiration Trait in an Upper-Mid South Soybean Recombinant Inbred Line Population (“Jackson” × “KS... by Sayantan Sarkar (11975699)

“…A secondary objective was to undertake a genetic marker/quantitative trait locus (QTL) genetic analysis using the AgNO₃ phenotyping results. …”

DataSheet_2_Tryptophan synthase ß subunit 1 affects stomatal phenotypes in Arabidopsis thaliana.pdf by Midori N. Soda (14184509)

“…To elucidate the molecular mechanism of stomatal movements, we performed a genetic screen based on stomatal aperture-dependent weight decrease of detached leaves from EMS-treated Arabidopsis thaliana and isolated a rapid transpiration in detached leaves 2 (rtl2). …”

DataSheet1_Gas Bubble Dynamics During Methane Hydrate Formation and its Influence on Geophysical Properties of Sediment Using High-Resolution Synchrotron Imaging and Rock Physics M... by B. N. Madhusudhan (12833870)

“…<p>Gas bubble in aquatic sediments has a significant effect on its geophysical and geomechanical properties. …”

Image_1_CISD2 Promotes Resistance to Sorafenib-Induced Ferroptosis by Regulating Autophagy in Hepatocellular Carcinoma.tif by Bowen Li (200859)

“…Knockdown of CISD2 promoted a decrease in the viability of drug-resistant HCC cells. …”

Data_Sheet_1_Associations Between Colonic Motor Patterns and Autonomic Nervous System Activity Assessed by High-Resolution Manometry and Concurrent Heart Rate Variability.PDF by Yuhong Yuan (8347566)

“…Taking all motor patterns into account, our data show that colonic motor patterns are accompanied by increased parasympathetic activity and decreased sympathetic activity that may occur without eliciting a significant change in heart rate. …”

Image 1_Comparative analysis of cranberry fruit rot fungal diversity in Massachusetts from wild, organic, and conventional ecosystems using multiplex PCR.jpg by Salisu Sulley (22059035)

“…Colletotrichum spp. persisted in 43% of the conventional bogs but detected only in one of the two years studied in organic and wild bogs resulting in 0% persistence from one year to the next. The study also noted a general decrease in Botryosphaeria vaccinii and an increase in Physalospora vaccinii across all bog types. …”

Optimized MLP network model. by Yanlin Liu (398738)

“…<div><p>To investigate the interplay among technological innovation, industrial structure, production methodologies, economic growth, and environmental consequences within the paradigm of a green economy and to put forth strategies for sustainable development, this study scrutinizes the limitations inherent in conventional deep learning networks. …”

Presentation 1_Open-Label-Placebos can reduce pain, but not indigestion during gluten challenge in chronic pain patients.pdf by Lena Paschke-Dahl (21477452)

“…Positive instructions led to a decrease in pain (T0-T2) while neutral instructions led to an increase in pain. …”

Table_1_Trends in the Epidemiology of Leishmaniasis in the City of Barcelona (1996–2019).DOC by David Palma (4968895)

“…There was an increase of foreign origin cases, and a decrease in the number of cases associated to any immunosuppression.…”

Only 52 of the 256 possible genotypes between PfCRT^3D7 and the CQ-transporting PfCRT^Dd2 isoform have measured phenotypes. by Zachary R. Sailer (4025459)

“…Five of the eight steps increase CQ transport activity, two have no effect, and the final step causes a decrease.</p>…”

Data_Sheet_3_Phenotyping and Quantitative Trait Locus Analysis for the Limited Transpiration Trait in an Upper-Mid South Soybean Recombinant Inbred Line Population (“Jackson” × “KS... by Sayantan Sarkar (11975699)

“…A secondary objective was to undertake a genetic marker/quantitative trait locus (QTL) genetic analysis using the AgNO₃ phenotyping results. …”

Mutations of specific tyrosine residues and proline rich domains of BANK1 abrogated the association with PLCg2. by Manuel Bernal-Quirós (394717)

“…The PP513LL mutation does not affect the tyrosine phosphorylation of BANK1, however it leads to a decrease in binding to PLCg2. (E) Co-expression in HEK293T cells of the two isoforms of BANK1 renders equivalent recovery of both isoforms in the anti-PLCg2 immunoprecipitate, indicating that exon 2 did not participate in the binding between BANK1 and PLCg2.…”

Image 1_The role of Sophora alopecuroides alkaloids in colon health of lambs fed high-concentrate diets for extended periods: impact on barrier function, antioxidation, and microfl... by Shufang Li (3183168)

“…Furthermore, there was a significant increase in Bacteroidetes and a decrease in Firmicutes in the HCT group (p < 0.01). …”