Exploiting the 2‑Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery by Pasquale Linciano (4426435)

“…In particular, compound <b>4m</b>, a biphenyl-thiadiazole-2,5-diamine with IC₅₀ = 16 μM, was able to potentiate the antitrypanosomal activity of the dihydrofolate reductase inhibitor methotrexate (MTX) with a 4.1-fold decrease of the EC₅₀ value. …”

Rv2346c enhances mycobacterial survival within macrophages by inhibiting TNF-α and IL-6 production via the p38/miRNA/NF-κB pathway by Jing Yao (169854)

“…<p>The intracellular survival of <i>Mycobacterium tuberculosis</i> (<i>Mtb</i>) has a central role in the pathogenesis of tuberculosis. …”

Image 1_Myristic acid beneficially modulates intervertebral disc degeneration by preventing endplate osteochondral remodeling and vertebral osteoporosis in naturally aged mice.pdf by Yan Gong (103494)

“…Additionally, MA notably inhibited osteoclast activity, as evidenced by a decrease in the number of osteoclasts and a significant suppression of F-actin formation. …”

Image 1_Linkage of jockey falls and injuries with racehorse injuries and fatalities in Thoroughbred flat racing in Victoria, Australia.pdf by Ashleigh V. Morrice-West (17273977)

“…</p>Results<p>The incidence of MSI was 21.21 (20.84, 21.59), racehorse fatalities 0.55 (0.50, 0.61), jockey falls was 3.01 (2.80, 3.24), and jockey injuries 1.79 (1.63, 1.97) per 1000 flat race starts. There was a decrease in racehorse MSI and jockey falls over the study period but no change in racehorse fatality or jockey injury incidence. …”

Identifying the Basal Ganglia Network Model Markers for Medication-Induced Impulsivity in Parkinson's Disease Patients by Pragathi Priyadharsini Balasubramani (749707)

“…Computational modeling suggested that PD-OFF patients have higher punishment sensitivity, while healthy controls showed comparatively higher risk sensitivity. A significant decrease in sensitivity to punishment and risk was crucial for explaining behavioral changes observed in PD-ON ICD patients. …”

Table_1_Gender Differences in 3-Month Outcomes of Erenumab Treatment—Study on Efficacy and Safety of Treatment With Erenumab in Men.DOCX by Raffaele Ornello (5213582)

“…<p>Objective: We reported gender-specific data on the efficacy and safety of erenumab, a monoclonal antibody antagonizing the calcitonin gene-related peptide (CGRP) receptor.…”

Village-Randomized Clinical Trial of Home Distribution of Zinc for Treatment of Childhood Diarrhea in Rural Western Kenya by Daniel R. Feikin (153640)

“…In rural Africa, most children with diarrhea are not brought to health facilities. In a village-randomized trial in rural Kenya, we assessed if zinc treatment might have a community-level preventive effect on diarrhea incidence if available at home versus only at health facilities.…”

<i>FoxO6</i> regulates Hippo signaling and growth of the craniofacial complex by Zhao Sun (283073)

“…<i>FoxO6</i>^<i>-/-</i> mice have significantly reduced Hippo Signaling caused by a decrease in <i>Lats1</i> expression and decreases in <i>Shh</i> and <i>Runx2</i> expression, suggesting that <i>Shh</i> and <i>Runx2</i> are also linked to Hippo signaling. …”

Co-immunoprecipitation and BiFC experiments related to Abd-B and Exd interaction. by Jesús R. Curt (20553231)

“…Protein present in the co-IPs is indicated above the gels. There is a significant decrease in the amount of the Abd-B^W protein captured on the resin when compared to the Abd-B wildtype protein (24%), while Exd remains almost unchanged (2%). …”

Tissue-Specific Suppression of Thyroid Hormone Signaling in Various Mouse Models of Aging by W. Edward Visser (280330)

“…A strong induction of TH-inactivating deiodinase D3 and decrease of TH-activating D1 activities are observed in <i>Csb</i>^<i>m/m</i><i>/Xpa</i>^<i>-/-</i> livers. …”

Table_2_The Impact of Hippocampal Sex Hormones Receptors in Modulation of Depressive-Like Behavior Following Chronic Anabolic Androgenic Steroids and Exercise Protocols in Rats.XLS... by Dragica Selakovic (4068406)

“…<p>The aim of this study was to evaluate alterations in depressive-like behaviors in rats following chronic administration of a supraphysiological dose of anabolic androgenic steroids (AASs) as well as exposure to a prolonged exercise protocol. …”

Sustainable development strategies. by Yanlin Liu (398738)

“…<div><p>To investigate the interplay among technological innovation, industrial structure, production methodologies, economic growth, and environmental consequences within the paradigm of a green economy and to put forth strategies for sustainable development, this study scrutinizes the limitations inherent in conventional deep learning networks. …”

Image_3_CISD2 Promotes Resistance to Sorafenib-Induced Ferroptosis by Regulating Autophagy in Hepatocellular Carcinoma.tif by Bowen Li (200859)

“…Knockdown of CISD2 promoted a decrease in the viability of drug-resistant HCC cells. …”

DataSheet1_Genetic Loci Associated With COVID-19 Positivity and Hospitalization in White, Black, and Hispanic Veterans of the VA Million Veteran Program.DOCX by Gina M. Peloso (12036929)

“…We sought to determine genetic variants contributing to COVID-19 susceptibility and hospitalization in a large biobank linked to a national United States health system. …”

The PND mediates blue light/Ubr1-dependent loss of yEmRFP-associated fluorescence in yeast. by Leslie M. Stevens (7553234)

“…Yeast expressing <i>PND-yEmRFP</i> in the presence of Ubr1p, exhibited a dramatic decrease in response to illumination <b>(C, D)</b>. …”

S1 Dataset - by Yael Appelboom (20570815)

“…Mental effort rose from 17h onwards higher values, whereas a decrease in comfortability was seen from 21h onwards.…”

Defining Hypo-Methylated Regions of Stem Cell-Specific Promoters in Human iPS Cells Derived from Extra-Embryonic Amnions and Lung Fibroblasts by Koichiro Nishino (219736)

“…Thus, a group of genes becomes active through a decrease of methylation in their promoters. …”

Restoration of CFTR function in patients with cystic fibrosis carrying the F508del-CFTR mutation by Daniela De Stefano (131144)

“…In a pilot clinical trial involving 10 <i>F508del-CFTR</i> homozygous CF patients, the combination of cysteamine and EGCG restored BECN1, reduced SQSTM1 levels and improved CFTR function from nasal epithelial cells <i>in vivo</i>, correlating with a decrease of chloride concentrations in sweat, as well as with a reduction of the abundance of <i>TNF/TNF-alpha (tumor necrosis factor)</i> and <i>CXCL8</i> (<i>chemokine [C-X-C motif] ligand 8</i>) transcripts in nasal brushing and TNF and CXCL8 protein levels in the sputum. …”

Image_2_CISD2 Promotes Resistance to Sorafenib-Induced Ferroptosis by Regulating Autophagy in Hepatocellular Carcinoma.tif by Bowen Li (200859)

“…Knockdown of CISD2 promoted a decrease in the viability of drug-resistant HCC cells. …”

Data_Sheet_1_Vitamin D Status and Its Influence on the Health of Preschool Children in Hangzhou.docx by Zhaojun Chen (359184)

“…Data on the children's gender, age, body mass index (BMI), caries, and blood samples available for vitamin D analysis were collected from June to August 2018. A total of 325 children aged 36–48 months took part in a survey on the frequency of respiratory tract infections in the last year.…”