Randomized double-blinded pilot clinical study of the antidiabetic activity of <i>Balanites aegyptiaca</i> and UPLC-ESI-MS/MS identification of its metabolites by Hend Rashad (4260301)

“…</p> <p><b>Results:</b> Thirteen compounds were identified in BE using UPLC-ESI-MS/MS analysis among which five steroidal saponins, seven phenolic compounds and a sterol glucoside. At the end of the 8-week treatment, the treated group showed 26.88% decrease in 2 h postprandial plasma glucose relative to 2.6% increase in the placebo group, while fasting plasma glucose was reduced to 10.3%. …”

Image_2_Antifungal, Plant Growth-Promoting, and Genomic Properties of an Endophytic Actinobacterium Streptomyces sp. NEAU-S7GS2.TIF by Dongli Liu (2580382)

“…These results suggested that strain NEAU-S7GS2 may be a potential biocontrol agent and biofertilizer used in agriculture.…”

Image_1_Conventional-Vincristine Sulfate vs. Modified Protocol of Vincristine Sulfate and L-Asparaginase in Canine Transmissible Venereal Tumor.TIF by Chanokchon Setthawongsin (6568634)

“…<p>Background: Vincristine (VCR) is a mono-chemotherapy for canine transmissible venereal tumor (CTVT). …”

DataSheet1_Combined Administration of Vitamin D3 and Geniposide Is Less Effective than Single Use of Vitamin D3 or Geniposide in the Treatment of Ulcerative Colitis.PDF by Yingyu Lu (11492644)

“…This study was designed to determine the efficacy and mechanism of the single use and combination of geniposide and vitamin D₃ on a mouse model of acute colitis. Data showed that a single administration of geniposide (2 mg/kg) or vitamin D₃ (4 IU/day) could significantly improve the symptoms of UC and relieve colon damage. …”

Image_2_Protective Effect of Stachydrine Against Cerebral Ischemia-Reperfusion Injury by Reducing Inflammation and Apoptosis Through P65 and JAK2/STAT3 Signaling Pathway.tif by Li Li (14993)

“…<p>Stachydrine, a constituent of Leonurus japonicus Houtt which also called Japanese motherwort has been shown to improve vascular microcirculation and ameliorate endothelial dysfunction. …”

Image_5_OsDDM1b Controls Grain Size by Influencing Cell Cycling and Regulating Homeostasis and Signaling of Brassinosteroid in Rice.TIF by Mingliang Guo (4877395)

“…Consistent with the grain size, the outer parenchyma cell layers of lemma in osddm1b developed more cells with decreased size. OsDDM1b encoded a nucleus, membrane-localized protein and was distributed predominately in young spikelets and seeds, asserting its role in grain size. …”

DataSheet_1_Severe COVID-19 Is Associated With an Altered Upper Respiratory Tract Microbiome.docx by Meghan H. Shilts (5900660)

“…</p>Objective<p>Our primary objective was to identify URT microbiome signature/s that consistently changed over a spectrum of COVID-19 severity.</p>Methods<p>Using data from 103 adult participants from two cities in the United States, we compared the bacterial load and the URT microbiome between five groups: 20 asymptomatic SARS-CoV-2-negative participants, 27 participants with mild COVID-19, 28 participants with moderate COVID-19, 15 hospitalized patients with severe COVID-19, and 13 hospitalized patients in the ICU with very severe COVID-19.…”

Image 5_Therapeutic plasma exchange accelerates immune cell recovery in severe COVID-19.jpeg by Aurelie Guironnet-Paquet (15407171)

“…</p>Methods<p>In this study, we set up a prospective, randomised clinical trial (ClinicalTrials.gov ID: NCT04751643) and performed therapeutic plasma exchange (TPE) in severe COVID-19 patients in order to decrease excess cytokines and auto-antibodies and to assess whether adding TPE to the standard treatment (ST, including corticosteroids plus high-flow rate oxygen) could help restore immune parameters and limit the progression of acute respiratory distress syndrome (ARDS).…”

Image_1_Early Everolimus Initiation Fails to Counteract the Cytotoxic Response Mediated by CD8+ T and NK Cells in Heart Transplant Patients.TIF by Beatriz Díaz-Molina (5791361)

“…Our results imply that only early EVL conversion induces key changes in the post-transplant immune response, preserving an efficient anti-viral response, but simultaneously showing a limited ability to counteract the cytotoxic response to the allograft.…”

Data_Sheet_1_Projecting shifts in the distributions of Chinese endemic vertebrate species under climate and land-use change.pdf by Yiming Deng (2814844)

“…<p>Human-induced climate and land-use change impact species’ habitats and survival ability. A growing body of research uses species distribution models (SDMs) to predict potential changes in species ranges under global change. …”

Table_1_TIPE2 Suppresses Malignancy of Pancreatic Cancer Through Inhibiting TGFβ1 Mediated Signaling Pathway.docx by Fang Feng (2315416)

“…Moreover, the tumor-infiltrating lymphocytes from tumor-bearing mice were analyzed by flow cytometry, and showed that TIPE2 could promote T cell activation to exert an anti-tumor effect possibly through activation of DCs in a TGFβ1 dependent manner. In general, we described the multiple regulatory mechanisms of TIPE2 in pancreatic tumorigenesis and tumor microenvironment, which suggested TIPE2 may act as a potential therapeutic target in pancreatic cancer.…”

Image_5_Alcohol Impairs Immunometabolism and Promotes Naïve T Cell Differentiation to Pro-Inflammatory Th1 CD4+ T Cells.tif by Patrick M. McTernan (341264)

“…These results suggest that ethanol impairs CD4⁺ T cell immunometabolism and disrupts mitochondrial repair processes as it promotes CD4⁺ T cell differentiation to a pro-inflammatory phenotype.</p>…”

Image1_Iodide uptake by forest soils is principally related to the activity of extracellular oxidases.TIFF by Russell M. Grandbois (14703175)

“…Autoclaved soils, and soils amended with an enzyme inhibitor (sodium azide) or an antibacterial agent (bronopol), bound significantly less ¹²⁵I tracer (93%, 81%, 61% decrease, respectively) than the untreated control soils, confirming a microbial role in soil iodide uptake. …”

Image1_Age and Gender Specific Lung Cancer Incidence and Mortality in Hungary: Trends from 2011 Through 2016.JPEG by Lilla Tamási (177760)

“…The male-to-female incidence rate ratio reached 2.46–3.01 (p < 0.0001) among the 70–79 age group. We found 2–11% decrease in male incidence rate at most age groups, while a significant 1–3% increase was observed in older females (>60) annually during the study period.…”

Table1_Using Lidar and Historical Similar Meteorological Fields to Evaluate the Impact of Anthropogenic Control on Dust Weather During COVID-19.DOCX by Bin Chen (63682)

“…During the transportation, dust can interact with local air-borne dust and pollutants, and has a profound impact on the environment. A novel coronavirus (COVID-19) has been affecting human activities worldwide since early 2020. …”

STIM1 expression closely related to HNSCC cell apoptosis and participated in TG-induced ER stress. by Ping Li (31981)

“…<p>(A) Transfected with STIM1-siRNA in TSCCA and Hep2 could significantly increase cell apoptosis compared with control groups by FACS detection. …”

Marangoni Droplets of Dextran in PEG Solution and Its Motile Change Due to Coil–Globule Transition of Coexisting DNA by Tomohiro Furuki (13205503)

“…These results provide a blueprint for designing autonomous small robots using phase-separated droplets, which change the mobility and molecular distribution within the droplet in reaction with the environment. …”

Data_Sheet_4_Resolvin E1-ChemR23 Axis Regulates the Hepatic Metabolic and Inflammatory Transcriptional Landscape in Obesity at the Whole Genome and Exon Level.XLSX by Abrar E. Al-Shaer (6580940)

“…Notably, obese WT mice relative to lean controls showed a robust decrease in pathways related to the biosynthesis of unsaturated fatty acids. …”

Updated Emission Factors from Diffuse Combustion Sources in Sub-Saharan Africa and Their Effect on Regional Emission Estimates by David J. Pfotenhauer (6708245)

“…Combining our results with other recent in-field emission factors for rural Ghana, we explored updated emission estimates for Ghana using a region specific emissions inventory. Large differences are calculated for all updated source emissions, showing a 96% increase in OC and 78% decrease in EC compared to prior estimates for Ghana’s emissions. …”

Expression of Lin28B associated with stemness markers in HCC cells. by Shu-Wen Cheng (484650)

“…<p>Western blot analyses showed that Lin28B was overexpressed in captured EpCAM⁺ PLC/PRF/5 cells and Huh-7 cells but not in EpCAM⁺ HepG2 cells (A, upper panel). EpCAM⁺ PLC/PRF/5 cells demonstrated elevated levels of SOX2, Nanog and OCT4; EpCAM⁺ Huh-7 cells, SOX2 and OCT4; but EpCAM⁺ HepG2 cells, none (A, lower panel). …”