Proposed model of PsrA regulation of PQS production in <i>P</i>. <i>aeruginosa</i>. by Greg Wells (4672462)

“…This apparently causes a shortage of the octanoyl-CoA needed for PQS synthesis and therefore PQS production greatly decreases.…”

Low and high threshold (panels a and b, respectively) of the two models calculated for several values of the ORNs sensitivity distance () in order of magnitude (OM). by Mario Pannunzi (553941)

Firing rates of PNs (as maximum activity) in response to a single synchronous triangular pulse of 50 ms duration applied to both ORN groups. by Mario Pannunzi (553941)

Firing rates of ORNs (as maximum activity) in response to a single synchronous triangular pulse of 50 ms duration applied to both ORN groups. by Mario Pannunzi (553941)

AZP-531, an unacylated ghrelin analog, improves food-related behavior in patients with Prader-Willi syndrome: A randomized placebo-controlled trial by Soraya Allas (4752756)

“…AZP-531, a first-in-class UAG analog, was shown to inhibit the orexigenic effect of AG in animals, to improve glycemic control and decrease body weight in humans. …”

Effects of clinical and environmental factors on bronchoalveolar antibody responses to <i>Pneumocystis jirovecii</i>: A prospective cohort study of HIV+ patients by Robert J. Blount (292240)

“…Prior PCP was associated with increased BALF IgA responses to Msg and current PCP was associated with decreased IgA responses. …”

Densitometry scan of X-ray film from normal-phase TLC of incorporation of [1-¹⁴C] acetate into lipid fraction from <i>S</i>. <i>aureus</i> following PYRC treatment. by Erica C. Larson (1344687)

“…Incorporation of radiolabeled [1-¹⁴C] acetate was decreased uniformly across the radiolabeled components of the extract in a dose-related fashion.…”

During EAE development, SRG3 over-expression driven by the CD2 promoter enhances Th1 and Th17 differentiation, whereas SRG3 over-expression driven by the β-actin promoter increases... by Sung Won Lee (222509)

Suppression by extracellular QRNA from TNP Ts Sup free of exosomes, or miR-150 alone, associating with B-cell derived Ag-specific exosomes from the assayed CS-effector cell mixture... by Krzysztof Bryniarski (731989)

“…</b></u> Similarly, two day immune B-1 B cell-derived exosomes, supplemented with decreasing doses of miR-150 alone, mediated suppression of TNP-CS-effector cell adoptive transfer (Groups E-G), down to a dose of 750pg per eventual recipient, which is 50 femtomoles per eventual recipient (Group G). …”

HCV elicits differential expression of circRNAs. by Tzu-Chun Chen (787255)

“…<p>(<b>A</b>) Experimental overview to identify HCV-induced circRNAs in infected and mock-infected cells. …”

Quantification of the gene candidates likely involved in ChA biosynthesis by qRT-PCR. by Yang Hu (315392)

“…<b>(B)</b> Decreased expression levels of <i>CglaeA</i> in pG14 and restoration in pGP6. …”

Synthesis and Antileukemic Activities of Piperlongumine and HDAC Inhibitor Hybrids against Acute Myeloid Leukemia Cells by Yi Liao (575994)

“…Introducing C2-chloro substituent to <b>1</b>–<b>58</b> yielded <b>3</b>–<b>35</b> with increased cytotoxicity but decreased selectivity in noncancerous MCF-10A cells; eliminating C7–C8 olefin of PL obtained <b>3</b>–<b>31</b>/<b>3</b>–<b>98</b> scaffolds which were still more active than PL or SAHA in AML and were well-tolerated by MCF-10A cells. …”

Adult emergence of 3^rd instar and 5^th instar of RPW after feeding on different dsRNAs. by Muhammad Naeem Sattar (19828497)

Model of adaptations associated with the development of high-level β-lactam resistance. by Viralkumar V. Panchal (9167076)

“…<p>Strain <i>lysA</i>::p<i>mecA</i> (SJF4996) (left) expresses chromosomal <i>mecA</i>, with PBP2A protein (red hour glass) incorporated into the cell envelope. …”

Design and Synthesis of Novel Epigenetic Inhibitors Targeting Histone Deacetylases, DNA Methyltransferase 1, and Lysine Methyltransferase G9a with <i>In Vivo</i> Efficacy in Multip... by Obdulia Rabal (124515)

“…The corresponding epigenetic functional cellular responses are observed: histone-3 acetylation, DNA hypomethylation, and decreased histone-3 methylation at lysine-9. These chemical probes, multitarget epigenetic inhibitors, were validated against the multiple myeloma cell line MM1.S, demonstrating promising <i>in vitro</i> activity of <b>12a</b> (CM-444) with GI₅₀ of 32 nM, an adequate therapeutic window (>1 log unit), and a suitable pharmacokinetic profile. …”

Design and Synthesis of Novel Epigenetic Inhibitors Targeting Histone Deacetylases, DNA Methyltransferase 1, and Lysine Methyltransferase G9a with <i>In Vivo</i> Efficacy in Multip... by Obdulia Rabal (124515)

“…The corresponding epigenetic functional cellular responses are observed: histone-3 acetylation, DNA hypomethylation, and decreased histone-3 methylation at lysine-9. These chemical probes, multitarget epigenetic inhibitors, were validated against the multiple myeloma cell line MM1.S, demonstrating promising <i>in vitro</i> activity of <b>12a</b> (CM-444) with GI₅₀ of 32 nM, an adequate therapeutic window (>1 log unit), and a suitable pharmacokinetic profile. …”

Design and Synthesis of Novel Epigenetic Inhibitors Targeting Histone Deacetylases, DNA Methyltransferase 1, and Lysine Methyltransferase G9a with <i>In Vivo</i> Efficacy in Multip... by Obdulia Rabal (124515)

“…The corresponding epigenetic functional cellular responses are observed: histone-3 acetylation, DNA hypomethylation, and decreased histone-3 methylation at lysine-9. These chemical probes, multitarget epigenetic inhibitors, were validated against the multiple myeloma cell line MM1.S, demonstrating promising <i>in vitro</i> activity of <b>12a</b> (CM-444) with GI₅₀ of 32 nM, an adequate therapeutic window (>1 log unit), and a suitable pharmacokinetic profile. …”

Design and Synthesis of Novel Epigenetic Inhibitors Targeting Histone Deacetylases, DNA Methyltransferase 1, and Lysine Methyltransferase G9a with <i>In Vivo</i> Efficacy in Multip... by Obdulia Rabal (124515)

“…The corresponding epigenetic functional cellular responses are observed: histone-3 acetylation, DNA hypomethylation, and decreased histone-3 methylation at lysine-9. These chemical probes, multitarget epigenetic inhibitors, were validated against the multiple myeloma cell line MM1.S, demonstrating promising <i>in vitro</i> activity of <b>12a</b> (CM-444) with GI₅₀ of 32 nM, an adequate therapeutic window (>1 log unit), and a suitable pharmacokinetic profile. …”

Design and Synthesis of Novel Epigenetic Inhibitors Targeting Histone Deacetylases, DNA Methyltransferase 1, and Lysine Methyltransferase G9a with <i>In Vivo</i> Efficacy in Multip... by Obdulia Rabal (124515)

“…The corresponding epigenetic functional cellular responses are observed: histone-3 acetylation, DNA hypomethylation, and decreased histone-3 methylation at lysine-9. These chemical probes, multitarget epigenetic inhibitors, were validated against the multiple myeloma cell line MM1.S, demonstrating promising <i>in vitro</i> activity of <b>12a</b> (CM-444) with GI₅₀ of 32 nM, an adequate therapeutic window (>1 log unit), and a suitable pharmacokinetic profile. …”

Krüppel-Like Transcription Factor KLF1 Is Required for Optimal γ- and β-Globin Expression in Human Fetal Erythroblasts by Divya S. Vinjamur (2141155)

“…KLF1 also regulates BCL11A, a known repressor of adult γ-globin expression. …”