Structure-Based Design of a Chemical Probe Set for the 5‑HT_5A Serotonin Receptor by Anat Levit Kaplan (12126567)

“…Docking over 6 million molecules against a 5-HT_5AR homology model identified 5 mid-μM ligands, one of which was optimized to <b>UCSF678</b>, a 42 nM arrestin-biased partial agonist at the 5-HT_5AR with a more restricted off-target profile and decreased assay liabilities versus SB-699551. …”

B-THP-Ts decrease cellular ATP levels. by Lindsay B. Tulloch (1266861)

Decrease in circulating iNKT cell activation during regadenoson (RA) infusion into patients with COVID-19. by Joseph Rabin (7399436)

Subjects:

LRP1 interacts with GluA1 and regulates its turnover in neurons. by Ming Gan (673850)

In the absence of insulin, dexamethasone (Dex) decreases lipogenesis as measured by 1-[¹⁴C]-acetate incorporation into lipid in differentiated Chub-S7 cells in a dose de... by Laura L. Gathercole (341979)

TCR-induced proximal signaling is decreased in <i>Gimap5</i> deficient T cells. by Xi-Lin Chen (803969)

ST2-104 decreases the Aβ_25-35-mediated increase in intracellular Ca²⁺. by Yingshi Ji (9013004)

Aβ and 22C11 agonist decreased cholesterol uptake whereas the sAPP-derived peptide and SM-ϕ stimulated increased cholesterol uptake by Caco-2 cells. by Kendra L. Puig (334788)

JBPOS0101 decreased Amyloid Beta (Aβ) aggregates in the cortex and hippocampal regions in 5xFAD mouse brains. by Jihoon Jeong (4852690)

Inverse relationship between poison exon usage and expression of multiple sodium channels during mouse brain development. by Yuliya Voskobiynyk (9954619)

“…<p>(A) <i>Scn1a</i> transcripts including exon 20N are highly expressed in the developing mouse brain and decrease dramatically after birth (aqua bars), with a corresponding developmental increase in <i>Scn1a</i> expression (blue bars). …”

PI+ CD3+ T cells decrease at day 14 after IR while PI+ CD3- cells decrease at all time points. by Jordan A. Gunning (18143970)

Heat-treated spores show a decrease in the overall number of spores that are able to germinate and grow out within 5 hours. by Rachna Pandey (394151)

Blocking of MC1R, MC2R or MC5R causes a decrease in the enucleation ratio of erythrocytes. by Eriko Simamura (720229)

“…Cell number is significantly decreased after treatment with anti-MC2R nAb for 5 days; however, treatment with anti-MC1R nAb or anti-MC5R nAb does not have a significant effect (n = 3, ANOVA). …”

At E9.5 Actb^−/− neural crest cells show a significant decrease of cadherin-11 expression. by Davina Tondeleir (426905)

“…<p>(A) Quantification of N-cadherin intensities in Actb^+/+ and Actb^−/− migratory cells adjacent to the neural tube at E8.5 and E9.5 (left graph, Y-axis: relative intensities) and colocalization of N-cadherin with p75 in migratory cells at E8.5 and E9.5 (right graph, Y-axis: colocalization index on a scale from 0 to 1). …”

Trend of temperature decrease in thermogradient freezer during the night from 7:00 P.M. to 5:00 A.M. by Alireza Hasanfard (13919335)

“…<p>Trend of temperature decrease in thermogradient freezer during the night from 7:00 P.M. to 5:00 A.M.…”

Shifting <i>V. cholerae</i> from glucose-based to starch-based conditions leads to a decrease in CT production. by Juliane Kühn (669504)

rVλ6Wil fibrils cause a decrease in cardiomyocytes MTT reduction without inducing cell death. by Helen P. McWilliams-Koeppen (116503)

“…(C) Cell number, quantified using crystal violet (black) did not decrease over 72 h of incubation with 1 μM rVλ6Wil fibrils despite a decrease in MMT reduction (grey; n = 3 samples per time point). …”

Mammalian METTL10 is an EF1A1 KMT. by Tadahiro Shimazu (619411)

KDM6A mRNA expression is decreased in PTFE mice. by Simon Lebek (9756148)

RNF5 depletion decreases cellular gene expression and lytic replication through increased EphA3 and EphA4 level in iSLK.219 cells. by Xiaojuan Li (351842)