Identification of a Hydroxypyrimidinone Compound (<b>21</b>) as a Potent APJ Receptor Agonist for the Potential Treatment of Heart Failure by Wei Meng (505670)

“…Due to the increased polarity at C2, the permeability for these compounds decreased. Further adjustment of the polarity by replacing the N1 2,6-dimethoxyphenyl group with a 2,6-diethylphenyl group and reoptimization for the potency of the C5 pyrroloamides resulted in potent compounds with improved permeability. …”

Identification of a Hydroxypyrimidinone Compound (<b>21</b>) as a Potent APJ Receptor Agonist for the Potential Treatment of Heart Failure by Wei Meng (505670)

“…Due to the increased polarity at C2, the permeability for these compounds decreased. Further adjustment of the polarity by replacing the N1 2,6-dimethoxyphenyl group with a 2,6-diethylphenyl group and reoptimization for the potency of the C5 pyrroloamides resulted in potent compounds with improved permeability. …”

Identification of a Hydroxypyrimidinone Compound (<b>21</b>) as a Potent APJ Receptor Agonist for the Potential Treatment of Heart Failure by Wei Meng (505670)

“…Due to the increased polarity at C2, the permeability for these compounds decreased. Further adjustment of the polarity by replacing the N1 2,6-dimethoxyphenyl group with a 2,6-diethylphenyl group and reoptimization for the potency of the C5 pyrroloamides resulted in potent compounds with improved permeability. …”

HCMV US27 correlates with decreased expression of p21 and Sestrin-2. by Carolyn C. Tu (663652)

Inhibition of the V-ATPase by SidK. by Jianhua Zhao (531939)

Subjects:

Increased severity of colitis and decreased colonic lengths in P90 mice fed by a synthetic diet [low cellulose (2.5%, LC) as fiber] compared to regular chow (12.5% dietary fiber). by Dorottya Nagy-Szakal (378382)

High glucose-containing media decreases mitochondrial membrane potential and ATP levels of in mixed glia cultures. by Yung-Cheng Huang (3443450)

Subjects:

Backbone Isomerization to Enhance Thermal Stability and Decrease Mechanical Sensitivities of 10 Nitro-Substituted Bipyrazoles by Jingwei Meng (91923)

Backbone Isomerization to Enhance Thermal Stability and Decrease Mechanical Sensitivities of 10 Nitro-Substituted Bipyrazoles by Jingwei Meng (91923)

Backbone Isomerization to Enhance Thermal Stability and Decrease Mechanical Sensitivities of 10 Nitro-Substituted Bipyrazoles by Jingwei Meng (91923)

Magnitude of the different types of change for the seven considered MEMs forced with GFDL-SSP5-8.5. by Vianney Guibourd de Luzinais (16871842)

Distribution of pulmonary ventilation assessed by center of ventilation (CoV) presented over the five time points: Induction-SB, MV-5min, MV-30min, MV-late and recovery-SB. by Milena S. Nascimento (14803681)

1,25D and phosphate treatment of Ocy454 cells decreases expression of genes implicated in perilacunar matrix resorption. by Ye Yuan (531126)

QA treatment decreases the expression of PP1, PP2 and PP5 but increases the expression of PP2B: by Abdur Rahman (261729)

Decreased expression of 5-HT-specific genes in adult <i>Lmx1b</i> iCKO mice. by Ning-Ning Song (233637)

Using climate envelope models to identify potential ecological trajectories on the Kenai Peninsula, Alaska by Dawn Robin Magness (6157265)

“…We use two lines of evidence, model convergence and empirically measured rates of change, to identify the following plausible ecological trajectories for the peninsula: (1.) alpine tundra and sub-alpine shrub decrease, (2.) perennial snow and ice decrease, (3.) forests remain on the Kenai Lowlands, (4.) the contiguous white-Lutz-Sitka spruce complex declines, and (5.) mixed conifer afforestation occurs along the Gulf of Alaska coast. …”

Luciferase reporter expression analysis in A427-derived xenograft tumors following IT injection of rH17d’-Ad5 vectors. by Christopher M. Gentile (6640331)

S5 Fig - by Meihui Chen (1670020)

Supplementary Material for: Lung adenocarcinoma size decrease after SARS-CoV-2 vaccination during long-term pembrolizumab treatment: A case report by Fujii K. (14520329)

Data_Sheet_5_A systematic review and meta-analysis of interventions to decrease cyberbullying perpetration and victimization: An in-depth analysis within the Asia Pacific region.PDF by Ida Khairina Kamaruddin (14512328)