Protein arginine methyltransferase 5 (PRMT5) promotes survival of lymphoma cells via activation of WNT/B-catenin and AKT/GSK3B proliferative signaling by Chung, Jihyun

“…We show that PRMT5 stimulates WNT/B-CATENIN signaling through direct epigenetic silencing of pathway antagonists, AXIN2 and WIF1, and indirect activation of AKT/GSK3 signaling.PRMT5 inhibition with either shRNA-mediated knockdown or a specific small molecule PRMT5 inhibitor, CMP-5, not only leads to derepression of WNT antagonists and decreased levels of active phospho-AKT (Thr-450 and Ser-473) and inactive phospho- GSK3B (Ser-9) but also results in decreased transcription of WNT/B-CATENIN target genes, CYCLIN D1, c-MYC, and SURVIVIN, and enhanced lymphoma cell death. …”
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Decreased methylglyoxal-mediated protein glycation in the healthy aging mouse model of ectopic expression of UCP1 in skeletal muscle by Jinit, Masania

“…In aged HSA-mUCP1 mice, urinary MG-derived AGEs/FL ratio was decreased ca. 60% whereas there was no change in CML/FL ratio – a marker of oxidative damage. …”
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Decreased methylglyoxal-mediated protein glycation in the healthy aging mouse model of ectopic expression of UCP1 in skeletal muscle by Jinit, Masania

“…In aged HSA-mUCP1 mice, urinary MG-derived AGEs/FL ratio was decreased ca. 60% whereas there was no change in CML/FL ratio – a marker of oxidative damage. …”
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Multifunctional self-healing polymeric nanocomposite coatings for corrosion inhibition of steel by Bahgat, Ahmed

“…The electrochemical studies indicate that the corrosion rate of the steel samples coated with the epoxy modified with the healing additives decreases after 5 days of immersion in saline water.…”
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Multifunctional self-healing polymeric nanocomposite coatings for corrosion inhibition of steel by Ubaid F.

“…The electrochemical studies indicate that the corrosion rate of the steel samples coated with the epoxy modified with the healing additives decreases after 5 days of immersion in saline water.…”
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Development And Performance Evaluation Of Smart Polymeric Coatings For Corrosion Protection Of Steel by Khan, Adnan

“…Consequently, they are a promising solution for longer durability of coated piping steel and decreased operation expense. …”
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Corrosion behavior of API-X120 carbon steel alloy in a GTL F-T process water environment at low COD concentration by Ewis, Dina

“…The effect of temperature, time and rotation speed of FT-GTL process water on the corrosion rate of API X-120 carbon steel was investigated. Electrochemical impedance spectroscopy and potentiodynamic polarization techniques were used to determine the carbon steel corrosion rate under temperatures ranging from 293 to 323 K and rotation speed of 0, 500, 1000, 2000 rpm when the immersion time was 0.5, 1, and 2 h. …”
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Evidence of two mechanisms involved in Bacillus thuringiensis israelensis decreased toxicity against mosquito larvae: Genome dynamic and toxins stability by Elleuch, Jihen

“…This bacterium is characterized by a dynamic genome able to win or lose genetic materials which leads to a decrease in its effectiveness. …”
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Molecular insights of the G2019S substitution in LRRK2 kinase domain associated with Parkinson's disease: A molecular dynamics simulation approach. by Agrahari, Ashish Kumar

“…This substitution was identified in both familial and sporadic forms of PD with a higher frequency. Few computational studies have reported the impact of G2019S substitution on inhibitors of the kinase domain of LRRK2. …”
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Investigation of solar PV performance under Doha weather using a customized measurement and monitoring system by Touati, Farid

“…Results predict that the maximum power output from a Poly-crystalline panel decreases by around 30% for a dust exposure of five months. …”
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A 5-year trend in the use of sodium-glucose co-transporter 2 inhibitors and other oral antidiabetic drugs in a Middle Eastern country by Zaghloul, Nancy

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Mechanical characteristics of ultra-high performance steel FRC made with recycled concrete aggregates by Alnahhal, W.

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A BRET-based Mpro biosensor containing a nanobody and tandem cleavage sites shows an increased cleavage rate by Geethakumari, Anupriya M

“…Here, we report the engineering of a Bioluminescence Resonance Energy Transfer (BRET)-based SARS-CoV-2 main protease (Mpro) biosensor containing the Mpro N-terminal autocleavage sequence in tandem and a nanobody that shows an enhanced rate of Mpro-mediated proteolytic cleavage. …”
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Simulation and experimental study of underwater dissimilar friction-stir welding between aluminium and steel by Eyvazian, Arameh

“…473 and 573 K for the aluminum and steel sides, respectively) led to sub-stantial refining the grain structure and formation of a thinner IMC layer. …”
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Effects of SARS-CoV-2 Alpha, Beta, and Delta variants, age, vaccination, and prior infection on infectiousness of SARS-CoV-2 infections by Qassim, Suelen H.

“…Using the cycle threshold (Ct) value of an RT-qPCR-positive test to proxy the inverse of infectiousness, we investigated infectiousness of SARS-CoV-2 infections by variant, age, sex, vaccination status, prior infection status, and reason for testing in a random sample of 18,355 RT-qPCR-genotyped infections. …”
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L5 Spinal Nerve Axotomy Induces Distinct Electrophysiological Changes in Axotomized L5- and Adjacent L4-Dorsal Root Ganglion Neurons in Rats . by Djouhri, Laiche

“…Consistent with this hypothesis, we found (7 days post-SNA), in SNA rats with established pain hypersensitivity, slower AP kinetics in axotomized L5-neurons and faster AP kinetics in L4-nociceptive neurons including decreased rise time in Aδ-and Aβ-fiber nociceptors, and after-hyperpolarization duration in Aβ-fiber nociceptors. …”
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Pollution Characteristics of Particulate Matter (PM2.5 and PM10) and Constituent Carbonaceous Aerosols in a South Asian Future Megacity by Aslam, Afifa

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Performance and computational studies of two soluble pyran derivatives as corrosion inhibitors for mild steel in HCl by Khattabi M.

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An Improved Fault Tolerant Five-Phase Induction Machine Using A Combined Star/Pentagon Single Layer Stator Winding Connection by Abdel-Khalik, Ayman S.

“…For the healthy case, the machine is similar to a conventional star connected five-phase machine. …”
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The impact of COVID-19 pandemic lockdown on smoking habits and lifestyle: A cross-sectional study by Khamees, Almu'atasim

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