Simplified balance model of context-dependent effects of binding sites for transcriptional activators. by Kaiser J. Loell (17797684)

“…Stepwise addition of sites for a single TF first increase then decrease activity. …”

Fig 1 - by Simone Bach (9339740)

“…The genome harbors 7 protein genes whose mRNA expression levels (schematically shown below the genome, terminal dots indicating the 5’-cap) decrease from the first (NP) to the last (L) mRNA. …”

Modulation of Notch signaling affects axon outgrowth. by Ming Shi (78991)

“…(B–B'') Mis-expression of NICD results in a drastic decrease in the number of commissural axons crossing the midline. …”

Error-threshold exists in fitness landscapes with lethal mutants-0 by Nobuto Takeuchi (24907)

“…The notation and parameters are as follows (unless stated otherwise): The broken line is for = 0.05; the solid line is for = 0.5; the dotted line is for = 1.0; /= 0.99. Points (circles and plus signs) are calculated through the comparison of the first and second greatest eigen values of the model with back mutation [see "How high must lethality be to introduce an error-threshold" and Fig. 4(A) for details]. = 0.05 (the same as in Fig. 3) and = 0.99, unless stated otherwise. …”

Genome-Wide Screen of Three Herpesviruses for Protein Subcellular Localization and Alteration of PML Nuclear Bodies by Jayme Salsman (43452)

“…<div><p>Herpesviruses are large, ubiquitous DNA viruses with complex host interactions, yet many of the proteins encoded by these viruses have not been functionally characterized. As a first step in functional characterization, we determined the subcellular localization of 234 epitope-tagged proteins from herpes simplex virus, cytomegalovirus, and Epstein–Barr virus. …”

Functional performance indicators associated with hypertension in older people by Emille Silva Santos (15475360)

Modulation of performance during learning. by Daniel Ramandi (10047543)

“…The ‘W_exp’ value shows the weight of the exponential component in each distribution. (B) A longitudinal comparison of the average exponential fit weight between WT and zQ175 mice reveals that while WT mice show a decreasing trend, indicating a shift towards longer duration (“timed”) trials, zQ175 mice maintain a consistently high exponential weight, demonstrating no significant change over time (b; RM two-way ANOVA, genotype p = 0.0106 F(1, 22) = 7.795, days p < 0.0001 F(5.262, 115.4) = 7.616, interaction p < 0.0001 F(57, 1250) = 2.834). …”

Effect of microglia depletion on cell viability in the retinal explants. by Rosa M. Ferrer-Martín (623505)

“…Bars represent mean values ± SEM of 5 explants per condition. *** denotes significant differences (P<0.001, Student’s t-test).…”

Mechanism of GaAs surface sulfidation by Al Marri, M.J.

“…Furthermore, the intensity of the S - O bond (S 2p at 169.1 eV) decreased with time, presumably due to arsenic sulfate dissolution. …”
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Data_Sheet_1_Regulation of NADPH Oxidase-Mediated Superoxide Production by Acetylation and Deacetylation.pdf by Ning Xia (196015)

“…Computational modeling analyses revealed that K166 deacetylation of Rac1 led to a 5-fold reduction in its binding affinity to guanosine-5'-triphosphate, and a 21-fold decrease in its binding potential to p67phox. …”

Fig 1 - by M. Latorre (8840546)

“…<p>Fully developed, mechanobiologically equilibrated, axisymmetric dilatations of an initially cylindrical aortic segment caused by a mild (first column) or severe (second column) localized (via the respective parameter <i>ϑ</i>_{<i>central</i>} in Eq (<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1008273#pcbi.1008273.e024" target="_blank">9</a>)) loss of elastic fiber integrity (first row, parameter <i>c</i>^<i>e</i>, mild 32% and severe 62% reduction), decrease in collagen cross-linking (second row, parameter , mild 9%, severe 23% reduction), loss of smooth muscle contractility (third row, parameter <i>T</i>_<i>max</i>, mild 60%, severe 100% reduction), compromised mechanosensing (fourth row, parameter <i>δ</i>, mild 7.5%, severe 18.5%, absolute), or compromised mechanoregulation (fifth row, parameter <i>G</i>^<i>c</i>, mild 0.4%, severe 1.2%, relative change), with the risk factors of hypertension (third column, 50% increase in blood pressure) and aortic aging (fourth column, uniform 30% loss of elastic fiber integrity) superimposed on the mild insults. …”

Image_2_Pharmacological Preconditioning Using Diazoxide Regulates Store-Operated Ca2 + Channels in Adult Rat Cardiomyocytes.JPEG by Raúl Sampieri (8297634)

“…Previously, we reported that pharmacological preconditioning (PPC) leads to a decrease in the amplitude of L-type calcium channel current in the heart. …”

Image_1_Liver-Specific Knockdown of Class IIa HDACs Has Limited Efficacy on Glucose Metabolism but Entails Severe Organ Side Effects in Mice.TIF by Nicole Ziegler (6893297)

“…For that, siRNAs selectively targeting HDAC4, 5 and 7 were selected and used to achieve a combinatorial knockdown of these three class IIa HDAC isoforms. …”

Macro-regions of Brazil. by Arnauld Kaufman (12731976)

“…Our results demonstrated a significant increase in the AAPC in Brazil’s less than 1-year-old age group and a decrease in children from 5 to 19 years old. …”

Table_1_Liver-Specific Knockdown of Class IIa HDACs Has Limited Efficacy on Glucose Metabolism but Entails Severe Organ Side Effects in Mice.docx by Nicole Ziegler (6893297)

“…For that, siRNAs selectively targeting HDAC4, 5 and 7 were selected and used to achieve a combinatorial knockdown of these three class IIa HDAC isoforms. …”

Dissecting the Epstein–Barr virus entry pathway into astrocytes: unfolding the involvement of endosomal trafficking by Annu Rani (11223925)

“…</p> <p>EBV internalization decreased upon depletion of the lipid rafts.</p> <p>The dynamin protein plays a crucial role in EBV entry into astrocytes, and its depletion indicates a decrease in EBV entry.…”

Image_2_Liver-Specific Knockdown of Class IIa HDACs Has Limited Efficacy on Glucose Metabolism but Entails Severe Organ Side Effects in Mice.TIF by Nicole Ziegler (6893297)

“…For that, siRNAs selectively targeting HDAC4, 5 and 7 were selected and used to achieve a combinatorial knockdown of these three class IIa HDAC isoforms. …”

ICD-10 version 2015. by Arnauld Kaufman (12731976)

“…Our results demonstrated a significant increase in the AAPC in Brazil’s less than 1-year-old age group and a decrease in children from 5 to 19 years old. …”

CKDMR in Brazil. by Arnauld Kaufman (12731976)

“…Our results demonstrated a significant increase in the AAPC in Brazil’s less than 1-year-old age group and a decrease in children from 5 to 19 years old. …”

Image_1_Pharmacological Preconditioning Using Diazoxide Regulates Store-Operated Ca2 + Channels in Adult Rat Cardiomyocytes.JPEG by Raúl Sampieri (8297634)

“…Previously, we reported that pharmacological preconditioning (PPC) leads to a decrease in the amplitude of L-type calcium channel current in the heart. …”