The functional consequences of variants on enzyme activity. by Flávia S. Donaires (4370056)

“…<p><b>(A)</b> Four non-synonymous <i>TERT</i> heterozygous mutations (A243V, T726M, A1062T, and V1090M) were detected in HCC patients in both forward and reverse sequences; <i>in silico</i> analysis was performed by CADD, PolyPhen, and SIFT to predict the impact of each variant on the structure and function of the enzyme. …”

LCN2 has no significant effect on neurite length or neurotoxicity in the cultured hippocampal neurons. by Jae-Hong Kim (124622)

The timeline of the experiment. by Shadi Nazarizadeh (20108029)

“…This study focuses on examining the effects of dimethyl itaconate (DMI) on cognition, motor coordination, and anxiety-like behavior in male rats that have experienced HINS. 42 male Wistar newborn rats (PND10) were randomly divided into six groups (n = 7). 1) Control (Vehicle only); received DMI solvent (0.1ml) without applying hypoxia. 2–3) DMI; receiving (20 and 50 mg/kg; i.p). 4) HINS; they were placed in a hypoxia chamber with 7% oxygen and 93% nitrogen concentration for 15 minutes. 5–6) DMI+HINS; received DMI (20 and 50 mg/kg; i.p) 24h before hypoxia. …”

S1 Raw data - by Shadi Nazarizadeh (20108029)

“…This study focuses on examining the effects of dimethyl itaconate (DMI) on cognition, motor coordination, and anxiety-like behavior in male rats that have experienced HINS. 42 male Wistar newborn rats (PND10) were randomly divided into six groups (n = 7). 1) Control (Vehicle only); received DMI solvent (0.1ml) without applying hypoxia. 2–3) DMI; receiving (20 and 50 mg/kg; i.p). 4) HINS; they were placed in a hypoxia chamber with 7% oxygen and 93% nitrogen concentration for 15 minutes. 5–6) DMI+HINS; received DMI (20 and 50 mg/kg; i.p) 24h before hypoxia. …”

S1 Graphical abstract - by Shadi Nazarizadeh (20108029)

“…This study focuses on examining the effects of dimethyl itaconate (DMI) on cognition, motor coordination, and anxiety-like behavior in male rats that have experienced HINS. 42 male Wistar newborn rats (PND10) were randomly divided into six groups (n = 7). 1) Control (Vehicle only); received DMI solvent (0.1ml) without applying hypoxia. 2–3) DMI; receiving (20 and 50 mg/kg; i.p). 4) HINS; they were placed in a hypoxia chamber with 7% oxygen and 93% nitrogen concentration for 15 minutes. 5–6) DMI+HINS; received DMI (20 and 50 mg/kg; i.p) 24h before hypoxia. …”

Muscle nuclei clustering phenotype observed in <i>attP40</i> larvae. by Kevin van der Graaf (14259532)

H7N9 PB1 promotes autophagic degradation of MAVS. by Yan Zeng (120271)

“…<p>(A) Overexpression of PB1 decreases the MAVS protein level. …”

Metabolic labelling of <i>P</i>. <i>falciparum</i> glycolipids with GDP-[^<i>3</i>H]-mannose. by Michaela S. Bulloch (19557058)

Maps showing PC-level prevalence of (A) no-toilet households, (B) unimproved toilets, (C) shared toilets, and (D) private toilets. by Anoop Jain (12095423)

Effects on nuclei clustering of inserting Gal4-regulated TRiP <i>spatacsin (spat)</i> into <i>attP40</i>. by Kevin van der Graaf (14259532)

TRiP <i>atl</i> can have dominant effects on nuclear clustering in some genetic backgrounds. by Kevin van der Graaf (14259532)

The TGF-β1/Smads signaling pathway and α-SMA expression levels in mice. by Lu Lin (201289)

Effect of phyllanthus niruri on metabolic parameters of patients with kidney stone: a perspective for disease prevention by Nidia D. Pucci (5631659)

“…There were no significant changes in all periods for anthropometric and several serum measurements, including total blood count, creatinine, uric acid, sodium, potassium, calcium, urine volume and pH; a significant increase in urinary potassium from 50.5±20.4 to 56.2±21.8 mg/24-hour (p=0.017); magnesium/creatinine ratio 58±22.5 to 69.1±28.6mg/gCr24-hour (p=0.013) and potassium/creatinine ratio 39.3±15.1 to 51.3±34.7mg/gCr24-hour (p=0.008) from baseline to wash out. …”

TRAIL⁺ hepatic NK cells express CXCR3. by Takuya Yano (415157)

“…(G) The expression of CXCR3 was higher in TRAIL⁺ liver NK cells compared to that in TRAIL⁻ liver NK cells (n = 5). (H) CXCR3⁺ liver NK cell population decreased significantly after partial hepatectomy (n = 5). …”

EZH2 knockdown causes a significant reduction in SCLC cell viability. by Bradley P. Coe (102517)

“…(<b>C,D,G,H</b>) To assess the viability of <i>EZH2</i> knockdown relative to controls cells we performed MTT assays. Knockdown of EZH2 caused a significant and reproducible decrease in cell viability in both SCLC cell lines (Student's t-test, p<0.05).…”

A mutant in an acidic patch of Set1 abolishes its interaction with Spp1 but does not affect meiotic DSB formation. by Céline Adam (320770)

Sox2 direct interaction with mouse <i>Huwe1</i> and human <i>Huwe1</i> genes. by Yen-Fu Cheng (5819855)

Dietary Patterns Associated with Breast Cancer in the Middle East: A Scoping Review by Zamzam, Syed

Get full text
Get full text

Table 1_Case Report: Identification of a novel hemizygous CFAP47 variant in a primary ciliary dyskinesia patient with dual ciliary and flagellar defects.docx by Miao He (148269)

“…</p>Methods<p>We investigated a male patient with suspected PCD who exhibited “9 + 2” ultrastructural abnormalities in both bronchial cilia and sperm flagella. …”

Preconceptional Folate Supplementation and the Risk of Spontaneous Preterm Birth: A Cohort Study by Radek Bukowski (63008)

“…Comparing to no supplementation, preconceptional folate supplementation for 1 y or longer was associated with a 70% decrease in the risk of spontaneous preterm delivery between 20 and 28 wk (41 [0.27%] versus 4 [0.04%] spontaneous preterm births, respectively; HR 0.22, 95% confidence interval [CI] 0.08–0.61, <em>p</em> = 0.004) and a 50% decrease in the risk of spontaneous preterm delivery between 28 and 32 wk (58 [0.38%] versus 12 [0.18%] preterm birth, respectively; HR 0.45, 95% CI 0.24–0.83, <em>p</em> = 0.010). …”