Characterisation of a Tip60 Specific Inhibitor, NU9056, in Prostate Cancer by Kelly Coffey (129302)

“…Although an authentic sample of 4-methyl-5-bromoisothiazole was inactive against Tip60, in an <em>in vitro</em> HAT assay, 1,2-bis(isothiazol-5-yl)disulfane (NU9056) was identified as a relatively potent inhibitor (IC₅₀ 2 µM). …”

The S-DNA produced in the B-to-S transition does not promote RecA nucleoprotein filament formation. by Hongxia Fu (423266)

“…<p>(A) Time traces of the extension of an 876 bp DNA tether with two GC-rich ends recorded during B-to-S transition in force-increase scan and the reverse S-to-B transition in the subsequent force-decrease scan in 50 mM KCl, 10 mM MgCl₂, pH 7.4, at 24°C. …”

Chest Compression Synchronized Ventilation versus Intermitted Positive Pressure Ventilation during Cardiopulmonary Resuscitation in a Pig Model by Clemens Kill (745046)

“…Blood gas samples were drawn for each period, mean arterial (MAP) and centralvenous (CVP) blood pressures were continuously recorded. …”

NKCC1 activity is necessary for GB cell migration on a nanopatterned substrate. by Tomas Garzon-Muvdi (168470)

“…NKCC1 shRNA-transduced cells show a decreased migration speed and directionality when compared to control virus-transduced cells. …”

Percentage of open AMPA receptors after the release of a single vesicle of glutamate. by Jesus Montes (436513)

Supplementary Material for: Epidemiology of Transthyretin Familial Amyloid Polyneuropathy in Portugal: A Nationwide Study by Inês M. (5678270)

“…<b><i>Results:</i></b> Over 2010–2016 period, mean incidence rates was 0.87/100,000 (95% CI 0.68–1.10) corresponding to 71 new patients yearly, that has decreased 31% in the last 7 years. The proportion of late-onset cases (age ≥50 years) among incident cases was 28.7%. …”

Datasheet1_Quality of life, exercise capacity, cognition, and mental health of Chilean patients after COVID-19: an experience of a multidisciplinary rehabilitation program at a phy... by Valeria Paéz (17523354)

Neuropathological findings in a case with Marburg’s variant of MS (case MS-6). by Katsuhisa Masaki (119851)

“…Asterisks indicate vascular lumen (R, S). Scale Bar = 1 mm(A); 500 µm (B, C); 200 µm (D–I); 50 µm (J, K); 100 µm (L, M); 10 µm (N–Q); 20 µm (R); 50 µm (S).…”

Active Video Games and Health Indicators in Children and Youth: A Systematic Review by Allana G. LeBlanc (422298)

Steady state voltage, concentrations and electrochemical potentials for the nanopore in Fig 5a. by Liesbeth van Oeffelen (511929)

“…<p>The values shown are those in a plane through the axis of the nanopore, with <i>V</i>_<i>L</i>−<i>V</i>_<i>R</i> = 0.5 V and a surface charge density of −50mC/m². …”

The expressions of aP2 and LPL mRNA were assessed in mice livers. by Chung-Hwa Park (3637009)

VAN-exposed lineages exhibited a fitness tradeoff in the presence and absence of vancomycin. by Samuel E. Blechman (19506884)

“…<p>(<b>A-F</b>) Shown are growth parameters of cycle 50 VAN-exposed lineages relative to ancestral VRSA strains (dotted horizontal lines), as measured in the presence (<b>A-C</b>; 32 μg/ml) and absence (<b>D-F</b>) of vancomycin. …”

<i>In Silico</i> Identification and <i>In Vitro</i> and <i>In Vivo</i> Validation of Anti-Psychotic Drug Fluspirilene as a Potential CDK2 Inhibitor and a Candidate Anti-Cancer Drug by Xi-Nan Shi (765399)

The Efficacy of Hyperbaric Oxygen Therapy on Middle Cerebral Artery Occlusion in Animal Studies: A Meta-Analysis by Yang Xu (178421)

“…Subgroup analysis showed that a maximal neuro-protective effect was reached when HBO was administered immediately after MCAO with an absolute atmospheric pressure (ATA) of 2.0 (50% decrease; 95% CI, 43% -57% decrease; <i>p</i> < 0.0001) and more than 6 hours HBO treatment (53% decrease; 95% CI, 41% -64% decrease; <i>p</i> = 0.0005).…”

The Potential Connectivity of Waterhole Networks and the Effectiveness of a Protected Area under Various Drought Scenarios by Georgina O’Farrill (564895)

“…The Greater Calakmul Region of the Yucatan Peninsula (Mexico) has experienced a 16% decrease in precipitation over the last 50 years, which we hypothesise has affected water resource connectivity. …”

Data_Sheet_1_Variations in the SDN Loop of Class A Beta-Lactamases: A Study of the Molecular Mechanism of BlaC (Mycobacterium tuberculosis) to Alter the Stability and Catalytic Act... by Sourya Bhattacharya (8441028)

“…A significant decrease in melting temperature (BlaC T_M 60°C, S130A T_M 50°C, and S130G T_M 45°C), kinetic instability at higher temperature, and comparative dynamic instability correlate the fact that resistance to beta-lactam/beta-lactamase inhibitor combinations will likely not arise from the structural alteration of BlaC, therefore establishing confidence that this therapeutic modality can be potentially applied as a part of a successful treatment regimen against M. tuberculosis.…”

Data_Sheet_2_Variations in the SDN Loop of Class A Beta-Lactamases: A Study of the Molecular Mechanism of BlaC (Mycobacterium tuberculosis) to Alter the Stability and Catalytic Act... by Sourya Bhattacharya (8441028)

“…A significant decrease in melting temperature (BlaC T_M 60°C, S130A T_M 50°C, and S130G T_M 45°C), kinetic instability at higher temperature, and comparative dynamic instability correlate the fact that resistance to beta-lactam/beta-lactamase inhibitor combinations will likely not arise from the structural alteration of BlaC, therefore establishing confidence that this therapeutic modality can be potentially applied as a part of a successful treatment regimen against M. tuberculosis.…”

TRF1 binding is inhibited by a single nucleotide gap in telomeric DNA by Patricia L. Opresko (7493)

“…Substrates (2.5 nM) were incubated alone (−) or together with decreasing concentrations of TRF1 (200, 100, 50 or 25 nM) (lanes 2–5 and 7–10) for 20 min at 4°C in TEL buffer. …”

A combined loss of PAR-2 and matriptase leads to underdevelopment of placental labyrinth. by Roman Szabo (138655)

“…P values: *<0.05, **<0.01, ***<0.001, Student's t-test, two-tailed. Scale bars: (<b>A, B</b>) 50 µm, (<b>C</b>) 100 um, (<b>D, E, F, H</b>) 200 µm, (<b>G, I</b>) 50 µm.…”

Survival of starvation-induced L1 arrest is a function of RIS activity. by Inka Busack (8474334)

“…B) Strong inactivation significantly decreases survival in L1 arrest whereas strong activation prolongs survival (three-parameter logistic fit, see also <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1010665#pgen.1010665.s012" target="_blank">S1 Table</a>, Fisher’s Exact Test was conducted when 50% of wild-type worms were alive (day 22)). …”