Image 2_Combined treatment with CDK4/6, CDK2, and CXCR1/2 inhibitors effectively halts the growth of BRAF wild-type melanoma tumors.tif by Jinming Yang (366356)

“…</p>Conclusions<p>The combination of all three inhibitors resulted in a tumor microenvironment characterized by increased IFNγ-producing CD4+ T cells, decreased CD4+FOXP3+ T regulatory cells (Tregs), and decreased IL-10-producing CD4+ T cells. …”

Summary of phospho-OPN and TRAcP isoform data. by Jani Luukkonen (4339744)

“…<p>The TRAcP 5B/5A ratio (A) is lowered in RF+ RA and this correlates with the level of OPN’s phosphorylation (B), since TRAcP 5B is the primary phosphatase of OPN, its phosphorylation is decreased in RA. …”

Chronic hyperglycemia alters the β-cell specific gene expression in pancreatic islets. by In-Su Cho (174455)

“…Relative mRNA levels were estimated from of Ct values summarized in Supporting <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0034860#pone.0034860.s005" target="_blank">Table S1</a> using 2^−ΔΔCt method. …”

Expression of RIO kinases is associated with EGFR and Akt activity in GBM cells. by Renee D. Read (268044)

“…With A443654, increased Akt-Ser473 phosphorylation occurs despite Akt inhibition <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1003253#pgen.1003253-Gallia1" target="_blank">[40]</a>; decreased Akt-Ser473 phosphorylation occurs with Akt inhibitor IV and MK-2206 <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1003253#pgen.1003253-Hirai1" target="_blank">[72]</a>. …”

Mrc1 influences pausing at MPS1 independently of the presence and absence of the imprint in <i>mat1</i> and its function in the S-phase checkpoint. by Juergen Zech (774105)

“…Please note that a decreased sporulation phenotype has previously been observed in a <i>hsk1-ts</i> mutant [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0132595#pone.0132595.ref059" target="_blank">59</a>]. …”

Data_Sheet_1_Spatiotemporal patterns of gross ecosystem product across China's cropland ecosystems over the past two decades.pdf by Jiaying Zhang (585596)

“…The values of the material, regulating, and cultural services have increased at a rate of (0.35 ± 0.01) × 10⁶ million CNY a⁻¹, (1.12 ± 0.10) × 10⁶ million CNY a⁻¹, and (0.002 ± 0.0002) × 10⁶ million CNY a⁻¹, respectively (P < 0.05). …”

RCECs TNF-α gene expression. by Yihui Chen (446576)

“…<p>RCECs cultured in NOP (normal osmotic pressure, 312mOsM) (A), HOP (high osmotic pressure, 500mOsM) (B), HOP+NAC (10 mM) (C), HOP+ DPI (10 µM) (D), HOP+ JNK inhibitor SP600125 (25 µM) (E) and HOP+ NF−kB inhibitor Bay11-7082(5 µM) (F) for 24 h. …”

Network properties of 16 epiphyte-tree networks measured in old-growth and disturbed forest fragments (four forest fragments, four sites per fragment). by Martín Piazzon (221515)

“…NODF  =  Almeida-Neto et al. 's nestedness metric <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0019637#pone.0019637-RodrguezGirons1" target="_blank">[40]</a>, based on overlap and decreasing fill. …”

DataSheet_1_An Individual-Based Model to Quantify the Effect of Salinity on the Production of Apocyclops royi (Cyclopoida, Copepoda).docx by Mizuki Yoshino (12865136)

“…The model outputs on total nauplii production match the experimental results. Both showed a progressive increase in nauplii production from 0 up to 21 PSU, beyond which the production decreases. …”

Fig 1 - by David Laloum (8587443)

“…We use the term “narrower” following Hausser et al. [<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1010399#pcbi.1010399.ref020" target="_blank">20</a>]. …”

Illustration of the History-Dependent Excitability concept. by Fabiano Baroni (234173)

Runner sequence offers modest release from transcription termination. by Ayan Banerjee (257912)

“…FLUC and hRLUC mRNA was measured by real-time RT-PCR and expressed as the relative ratio of hRLUC/FLUC mRNA. <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0006193#s2" target="_blank">Results</a> are shown as a percentage of the dsred control cell line. …”

Molecular Mimics of Classic P-Glycoprotein Inhibitors as Multidrug Resistance Suppressors and Their Synergistic Effect on Paclitaxel by Moustafa E. El-Araby (3626396)

“…On the other hand, combination of PTX and the non-cytotoxic Cur1-12V (10 μM) significantly decreased the IC₅₀ of PTX to 3.8 nM as well as the resistant fraction to 16.2%. …”

Experimental Demonstration That GDF11 Regulates <i>p</i>₁ and <i>v</i>₁ by Arthur D Lander (82004)

“…Explants were fixed at various times after BrdU addition and immunostained for BrdU and NCAM expression.</p> <p>(A–I) Cultures grown in GDF11 concentrations of 0 (A, D, and G), 0.5 (B, E, and H), and 10 (C, F, and I) ng/ml, fixed 18 h after BrdU addition (previous studies have shown that 18 h is sufficient time for INP progeny that become ORNs to express NCAM [<a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.1000015#pbio-1000015-b039" target="_blank">39</a>]). …”

Top ten classical HLA alleles associated with psoriasis, and comparison to HIV-1 controllers as published in [15]. by Haoyan Chen (183892)

“…P values and ORs for psoriasis samples were adjusted by ancestry, gender, and cohort. ORs greater than 1.0 correspond to psoriasis susceptibility and control of HIV-1, whereas ORs less than 1.0 correspond to decreased psoriasis susceptibility and lack of virologic control. …”

Reduced bending energy of double-membrane shapes, by Roland L. Knorr (178019)

“…Increasing the effective size of the vesicle decreases the barrier continuously. At the critical size, <i>r_sheet</i>/<i>r_rim</i> = 10.2, the energy barrier disappears and the sheet becomes unstable with respect to arbitrarily small perturbations, which transforms the sheet into a closed vesicle. …”

DataSheet_1_The Prognostic Value of FoxP3+ Tumour-Infiltrating Lymphocytes in Rectal Cancer Depends on Immune Phenotypes Defined by CD8+ Cytotoxic T Cell Density.docx by Sören Schnellhardt (11990585)

“…Stromal FoxP3+ cell densities were not associated with 10-year overall survival (OS). In the “immune-desert” phenotype, defined by very low stromal CD8+ cell density, a high density of stromal FoxP3+ T cells displayed a tendency towards an association with decreased 10-year OS (p = 0.179). …”

Orthogonal signal-corrected statistical results for the preprocessed spectra of EBC from 53 cats before and after induction of allergic asthma. by Yan G. Fulcher (1316178)

“…As VIP values rise above 1.0, they imply increasing diagnostic significance [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0164394#pone.0164394.ref054" target="_blank">54</a>]. …”

Knockdown of the β2-AR fails to prevent carvedilol-mediated inhibition of EGF-induced neoplastic transformation of JB6 P+ cells. by Kristan H. Cleveland (6714539)

“…<p>(A) qPCR indicates that transduction of JB6 P+ cells with lentiviruses carrying a short hairpin sequence for Adrb2 decreases β2-AR expression, n = 3. …”

Parameter Sensitivities and Temperature Compensation by Arun Mehra (380325)

“…</p><p>(F) Dependence of period and P-KaiC ratio as a function of KaiABC* stability mimicking KaiC mutant behaviors. (1) Rate constants are as in <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.0020096#pcbi-0020096-g002" target="_blank">Figure 2</a> (“wild-type behavior”); (2) Decreased P-KaiC ratios amplitudes and shorter periods (“short period KaiC mutant behavior”) are observed for a more stable KaiABC* complex relative to (1): k₄ = 2.3 μM⁻¹ h⁻¹, k₅ = 4.5 h⁻¹, k₆ = 1.0 h^−1; and (3) Long-period KaiC mutant behavior is observed when the KaiABC* complex is more stable compared to (1): k₄ = 4.0 μM⁻¹ h⁻¹, k₅ = 1.5 h⁻¹, and k₆ = 0.8 h⁻¹.…”