<i>In vitro</i> differentiation of <i>Mecp2</i> wild type ES cells is accompanied by large scale heterochromatin reorganization. by Bianca Bertulat (126768)

“…We noticed a highly significant (p<0.0001) decrease of mean chromocenter number per nucleus within the first two weeks of differentiation. …”

Two electrophysiological sleep states exist in the Argentine tegu. by Paul-Antoine Libourel (561599)

“…The vertical scale bars represent 100 μV. (B) Time frequency representation of 24 h of recording of a whitened LFP DVR split into four 6-h periods starting at 2 PM (in blue the low power, in red the high power). …”

MMP2 in stromal cell conditioned medium is important to drive PDAC cell invasion. by Hong Cao (122228)

“…MMP2 depletion in hPSC CM results in a >3-fold decrease in the percent of BxPC3 cells degrading the matrix (≥100 cells per condition, g) and a >8-fold decrease in the area degraded per cell in BxPC3 cells (≥10 cells per condition, h). …”

5OMV Inhibits HMGB1-Induced Tube Formation in HUVECs. by Wenyue Hou (10203722)

“…<p>Representative images <b>(A)</b> of the wound healing assay (captured at 0 h and 24 h post-scratching) demonstrated that co-treatment with 5OMV (100, 250, and 500 μg mL⁻¹) and HMGB1 (800 ng mL⁻¹) significantly attenuated HUVECs migration. …”

EWS/FLI-1 and R1507 influence the activation/expression of key molecules in the IGF-1 signaling pathway. by Helen J. Huang (201553)

“…An ELISA for IGF-BP3 was performed. Results show the mean and standard error of four experiments. Starting amounts of IGF-BP3 are higher than those in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0026060#pone-0026060-g002" target="_blank">Figure 2</a> because of the longer culture time required for transfection experiments. …”

Representative Macro- and Microscopic Traces of Different MthK Constructs Expressed in E. coli Membrane by Mario Meng-Chiang Kuo (376172)

“…Channels were activated by stepping the perfusate from EGTA to either Ca20 or Ca100 solution at pH 7.5 using a rapid perfusion system.…”

National Land Cover Database (NLCD) Tree Canopy Cover (TCC) Puerto Rico USVI by U.S. Forest Service (17476914)

“…For each year following 2011, on a pixel-wise basis TCC values are updated to a new baseline value if an increase or decrease of 10 percent TCC occurs relative to the 2008-2010 TCC baseline value. …”

TgPH1 retains membrane association in genetically-impaired PIKfyve cells. by Krishna Chintaluri (5340959)

“…<p>A. Live-cell imaging of Cos-7 cells expressing NES-iRFP-TgPH1 treated with vehicle alone or with 100 nM apilimod or 1 μM YM201636 for 1 h; the drugs cause a characteristic appearance of swollen vacuoles, some of which labelled with the TgPH1 probes. …”

2-DG reduced amyloid pathology through activation of the non-amyloidogenic pathway in 3xTgAD mice. by Jia Yao (323339)

“…Brain sections were stained for amyloid species (6E10) and microglia marker (Iba I). A, 2-DG induced significant decrease in APP, 56 kD, 27 kD and 16 kD Aβ oligomer protein level. …”

Effect of Gli blockade on growth of human ovarian cancer cells <i>in vivo</i>. by Qi Chen (144168)

“…Treatment was initiated in all groups (n = 8 each group) when mean tumor volume had reached 100 mm³. …”

Ecosystem organic carbon storage and their drivers across the drylands of China by Longwei Dong (10525061)

“…The effects of environmental variables on carbon density were found to be contingent on ecosystem type and soil depth. Mean annual precipitation had a strong positive effect on the spatial distributions of vegetation carbon density in both types of ecosystems. …”

Functional characterization of Ca²⁺-induced Cl⁻ responses of TG neurons. by Nicole Schöbel (120873)

“…C: Quantification of neurons displaying either a decrease, an increase, or no alteration of [Cl⁻]_i upon ATP stimulation (n = 76). …”

The potential mechanism for the elevated ROS levels. by Weimin Wang (145168)

“…(D) Gene expression of NOX2 and NOX4 in the control and Ara-C groups. (E) The mean increase/decrease of mitochondrial ROS and total ROS in Ara-C cells treated with DPI or Mito-Tempo. …”

Co-cultures of RGCs and Müller cells. by Xandra Pereiro (3924971)

“…The data represent the mean ± SEM. Scale bar = 100 μm, *p<0.05.</p>…”

TF maps and averaged profile of alpha oscillatory response. by Audrey Breton (534422)

“…<p>A) TF map depicting the color-coded mean energy (in μV²) in response to faces in the three player rank conditions (Highest, Middle and Lowest) at the electrode Pz. …”

SIM promotes axon like neuritogenesis in SH-SY5Y cells. by Varshiesh Raina (457377)

“…Note that SIM led to a significant (<i>p</i> < 0.05^*) increase in protein expression of NFL and β3-tubulin whereas GAP43 and Nestin displayed no change. phospho-Tyrosine Hydroxylase serine 31 (pTH-Ser31), a dopaminergic neuronal functional marker showed a significant (<i>p</i> < 0.05^*) decrease in protein levels at 6 hrs post SIM treatment. …”

Health and Economic Burden of Obesity in Brazil by Ketevan Rtveladze (142281)

“…However, an effective intervention to decrease obesity by just 1% will substantially reduce obesity burden and will have a significant effect on health care expenditure.…”

Estrogen dose-dependent depletion of oocytes. by Clémentine Chalmey (5657233)

“…Higher magnification of TRA98 labeling shows oocyte-specific expression (C). Scale bar = 100 µm. D–E. Stereological estimation of ovarian volume (D) and oocyte numbers per ovary (E) at PND3 in controls, and as a function of E2 dose, show a dose-dependent decrease of both parameters. …”

Effect of the lytic enzyme PeiR on M1 growth <i>in vitro</i>. by Sinead C. Leahy (244590)

“…Chloroform, a known potent inhibitor of methanogens, resulted in a similarly reduced methane yield (B), but the decrease in culture density was less (A), as expected since it halts metabolism rather than lysing cells. …”

RAGE blocking and APP inhibition synergistically reduce oxidative stress, apoptosis and rescue sequential gliocentric cell fate change in DS HNPs. by Jie Lu (139953)

“…(B) Graphs show the S100B stimulation for 24 hours dose dependently increase H₂O₂ production and decrease mitochondrial membrane potential which can be blocked by RAGE antibody (1 µg/ml) or dalteparin sodium (1 IU/ml) (<b><a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0022126#pone.0022126.s005" target="_blank">Figure S5A</a></b>). …”