TSS-targeted siRNA abolishes the heparanase expression in cancer cells. by Guosong Jiang (182435)

“…The symbols (# and Δ) indicate a significant decrease from untransfected control (mock) and a significant increase from pGL3/Basic, respectively.…”

Met-depleted mosquitoes exhibit metabolic defects. by Yuan Hou (767606)

“…<p>(A) A decrease in the glycogen levels was observed in Met-depleted adult female mosquitoes, as measured by colorimetry (<i>left</i>) and PAS staining (<i>right</i>). …”

DataSheet_1_Regulation of SPDEF expression by DNA methylation in advanced prostate cancer.pdf by Mousa Vatanmakanian (15171089)

“…</p>Results<p>In this report, we observed that: a) there is a gradual decrease in SPDEF expression with a concomitant increase in methylated CpG sites within the SPDEF gene during prostate cancer progression from lower to higher Gleason grade; b) Expression of DNMT’s (DNMT1, 3a and 3b) is increased during prostate cancer progression, and there is an inverse correlation between SPDEF and DNMT expression; c) SPDEF levels are decreased in RC77/T, a line of PCa cells from African American origin similar to PC3 and DU145 cells (CRPC cells), as compared to LNCaP cells , a line of androgen dependent cells,; d) the 5′ CpG island of SPDEF gene are hypermethylated in SPDEF-negative CRPC ( PC3, DU145 and RC77/T) cell lines but the same regions are hypomethylated in SPDEF-positive castrate sensitive (LNCaP) cell line ; (e) expression of SPDEF in PCa cells lacking SPDEF decreases cell migration and invasion, but has no significant effect on cell proliferation, and; (f) treatment with the demethylating agent, 5-aza-2′-deoxycytidine, or silencing of the DNMT’s by siRNA, partially restores SPDEF expression in SPDEF-negative PCa cell lines, and decreases cell migration and invasion.…”

Lc exerts anti-inflammatory effect on LPS-activated macrophage cell line RAW 264.7. by Zuzana Zakostelska (328326)

“…*P<0.05: the means were compared against a hypothetical mean of 100% by one sample t-test (B) The effect of Lc on NF-κB binding activity in LPS-stimulated RAW 264.7 cells. …”

Cell culture optimization: effect of collagen on chordoma cell growth (Batch 1) by Nindo Punturi (14025993)

“…</b>) U-CH1 cells undergo morphological changes and a decrease in proliferation when grown in the absence of collagen, as compared to U-CH1 cells grown on a collagen-coated surface. …”

Fis binding site modifications, Langevin dynamics simulations of DNA breathing, and EMSA experiments, the first set. by Kristy Nowak-Lovato (101951)

“…<p>(A) Langevin dynamics simulations demonstrating suppressed local DNA breathing dynamics in the FIS1S sequence (compare to FIS1 in <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1002881#pcbi-1002881-g002" target="_blank">Figure 2</a>). …”

Systematic review of evidence for the impact and effectiveness of the 1-3-7 strategy for malaria elimination by Richard J. Maude (9416228)

“…</p><h2>Conclusion </h2><p dir="ltr">Overall, the 1-3-7 approach was effectively implemented with a concomitant decrease in cases in malaria elimination settings, however, it was not possible to quantify impact as it was not implemented in isolation. …”

Total neutrophil and total macrophage concentrations for inflammatory mediator inhibition by different inhibitor concentrations. by Sridevi Nagaraja (833270)

“…We simulated chronic inflammation by increasing the initial platelet concentration by 100 fold, increasing the macrophage influx rate parameter by 1.5 fold, and simultaneously decreasing the platelet degradation rate parameter by 1.5 fold. …”

FA and glucose oxidations in SCD1-overexpressed cardiac myocytes. by Hiroki Matsui (330019)

“…<p>(A): FA oxidation was significantly increased in rat neonatal cardiac myocytes treated with 100 µM palmitic acid (PA). …”

ASIR prediction from 2020 to 2030 by sex. by Majed M. Ramadan (22379116)

“…Bahrain also saw a significant increase in male Age-standardized death rate (ASDR), despite all other countries experiencing a decrease. …”

Stability analysis on simulated and biological data. by Simon Dirmeier (7858847)

“…The correlations between bootstrap samples, however, decrease with a higher number of viruses.</p>…”

Temporal evolution of the dynamic cell compression within Matrigel-coated micro-piston devices. by Sevgi Onal (10871856)

“…<p>Time-lapse live cell imaging with 100 ms per frame was recorded for ladder pressure increase from 0 kPa up to 15.6 kPa and a short cycle at 15.6 kPa with gradual increase (from 0 kPa to 15.6 kPa) and decrease (from 15.6 kPa to 0 kPa) in 30 s for each. …”

Simulation of the relationship between distribution of synaptic efficacy and information transfer in cuneate neurons. by Fredrik Bengtsson (284376)

“…<p>A: Histogram showing EPSP amplitude distribution for N = 100 simulated neurons with 130 primary afferent synapses each. …”

Regulation of spine neck resistance does not generate robust changes in synaptic efficacy. by Allan T. Gulledge (325673)

“…<p>A) Top, ball-and-stick model neuron with 100 spines (200 MΩ neck resistance) along the dendrite. …”

EMS dose response curve. by Levi T. Morran (358030)

“…<p>Replicate populations of PX384 were exposed to five generations of mutagenesis across a range of different EMS concentrations. Mean fecundity generally decreased with increasing EMS concentration, however, exposure to 100 mM significantly elevated fecundity relative to much lesser concentrations of EMS (20 mM) (P<0.001, Tukey's HSD). …”

The impact of K⁺ channel blockers on the KDM1 activity. by Anda L. Iosip (9749747)

“…The half-activation potential V_1/2 was not much affected by Cs⁺ application (<i>n</i> ≥ 4; mean ± SD). (F) The unnormalized I_SS in 30 mM and 100 mM K⁺, with and without 30 mM Cs⁺, displays comparable current characteristics as the normalized I_SS-V curves in <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.3000964#pbio.3000964.g004" target="_blank">Fig 4A</a> (<i>n</i> = 17; mean ± SD). …”

Effects of Extracts from Thai Piperaceae Plants against Infection with <i>Toxoplasma gondii</i> by Arpron Leesombun (2805217)

“…<i>betle</i> extract resulted in 100% mouse survival following infection with 100,000 tachyzoites. …”

Modulating CFTR expression may limit SHS induced bacterial survival. by Inzer Ni (707909)

“…(D) CSE treatment (in 3C) significantly (**p<0.01) inhibits bacterial phagocytosis, while VRT-532 is unable to restore SHS impaired phagocytosis. (E) In a separate experiment (as described in 3C), media (100μl) was collected, spread on agar plates, and then incubated overnight at 37°C. …”

Hydrodynamic Characterization of Phase Separation in Devices with Microfabricated Capillaries by Anand N. P. Radhakrishnan (6823991)

“…The trailing edge of the liquid slugs (receding meniscus) approached the advancing meniscus at a constant speed, thus leading to a linear decrease of the liquid slug length. …”

Hydrodynamic Characterization of Phase Separation in Devices with Microfabricated Capillaries by Anand N. P. Radhakrishnan (6823991)

“…The trailing edge of the liquid slugs (receding meniscus) approached the advancing meniscus at a constant speed, thus leading to a linear decrease of the liquid slug length. …”