Video_1_Multi-omics analysis identifies IgG2b class-switching with ALCAM-CD6 co-stimulation in joint-draining lymph nodes during advanced inflammatory-erosive arthritis.mp4 by H. Mark Kenney (10320665)

“…Integration of single-cell and spatial transcriptomics revealed the increased IgG2b⁺ plasma cells localized in MARCO⁺ peri-follicular medullary sinuses. A concomitant decreased Fth1 expression (Early 2.5 ± 0.74 vs Advanced 1.0 ± 0.50 counts, p<0.001) within Advanced PLN sinuses was associated with accumulation of iron-laden Prussian blue positive macrophages in lymph nodes and synovium of Advanced TNF-Tg mice, and further validated in RA clinical samples. …”

Image_6_Multi-omics analysis identifies IgG2b class-switching with ALCAM-CD6 co-stimulation in joint-draining lymph nodes during advanced inflammatory-erosive arthritis.tif by H. Mark Kenney (10320665)

“…Integration of single-cell and spatial transcriptomics revealed the increased IgG2b⁺ plasma cells localized in MARCO⁺ peri-follicular medullary sinuses. A concomitant decreased Fth1 expression (Early 2.5 ± 0.74 vs Advanced 1.0 ± 0.50 counts, p<0.001) within Advanced PLN sinuses was associated with accumulation of iron-laden Prussian blue positive macrophages in lymph nodes and synovium of Advanced TNF-Tg mice, and further validated in RA clinical samples. …”

Video_3_Multi-omics analysis identifies IgG2b class-switching with ALCAM-CD6 co-stimulation in joint-draining lymph nodes during advanced inflammatory-erosive arthritis.mp4 by H. Mark Kenney (10320665)

“…Integration of single-cell and spatial transcriptomics revealed the increased IgG2b⁺ plasma cells localized in MARCO⁺ peri-follicular medullary sinuses. A concomitant decreased Fth1 expression (Early 2.5 ± 0.74 vs Advanced 1.0 ± 0.50 counts, p<0.001) within Advanced PLN sinuses was associated with accumulation of iron-laden Prussian blue positive macrophages in lymph nodes and synovium of Advanced TNF-Tg mice, and further validated in RA clinical samples. …”

Video_2_Multi-omics analysis identifies IgG2b class-switching with ALCAM-CD6 co-stimulation in joint-draining lymph nodes during advanced inflammatory-erosive arthritis.mp4 by H. Mark Kenney (10320665)

“…Integration of single-cell and spatial transcriptomics revealed the increased IgG2b⁺ plasma cells localized in MARCO⁺ peri-follicular medullary sinuses. A concomitant decreased Fth1 expression (Early 2.5 ± 0.74 vs Advanced 1.0 ± 0.50 counts, p<0.001) within Advanced PLN sinuses was associated with accumulation of iron-laden Prussian blue positive macrophages in lymph nodes and synovium of Advanced TNF-Tg mice, and further validated in RA clinical samples. …”

Image_4_Multi-omics analysis identifies IgG2b class-switching with ALCAM-CD6 co-stimulation in joint-draining lymph nodes during advanced inflammatory-erosive arthritis.tif by H. Mark Kenney (10320665)

“…Integration of single-cell and spatial transcriptomics revealed the increased IgG2b⁺ plasma cells localized in MARCO⁺ peri-follicular medullary sinuses. A concomitant decreased Fth1 expression (Early 2.5 ± 0.74 vs Advanced 1.0 ± 0.50 counts, p<0.001) within Advanced PLN sinuses was associated with accumulation of iron-laden Prussian blue positive macrophages in lymph nodes and synovium of Advanced TNF-Tg mice, and further validated in RA clinical samples. …”

Table_1_Residential greenness attenuated association of long-term air pollution exposure with elevated blood pressure: Findings from polluted areas in Northern China.docx by Yayuan Mei (12324884)

“…Sparse evidence exists regarding the modifying role of residential greenness in such effects.</p>Methods<p>A cross-sectional study was conducted in typically air-polluted areas in northern China. …”

Image_1_Multi-omics analysis identifies IgG2b class-switching with ALCAM-CD6 co-stimulation in joint-draining lymph nodes during advanced inflammatory-erosive arthritis.tif by H. Mark Kenney (10320665)

“…Integration of single-cell and spatial transcriptomics revealed the increased IgG2b⁺ plasma cells localized in MARCO⁺ peri-follicular medullary sinuses. A concomitant decreased Fth1 expression (Early 2.5 ± 0.74 vs Advanced 1.0 ± 0.50 counts, p<0.001) within Advanced PLN sinuses was associated with accumulation of iron-laden Prussian blue positive macrophages in lymph nodes and synovium of Advanced TNF-Tg mice, and further validated in RA clinical samples. …”

Image_2_Multi-omics analysis identifies IgG2b class-switching with ALCAM-CD6 co-stimulation in joint-draining lymph nodes during advanced inflammatory-erosive arthritis.tif by H. Mark Kenney (10320665)

“…Integration of single-cell and spatial transcriptomics revealed the increased IgG2b⁺ plasma cells localized in MARCO⁺ peri-follicular medullary sinuses. A concomitant decreased Fth1 expression (Early 2.5 ± 0.74 vs Advanced 1.0 ± 0.50 counts, p<0.001) within Advanced PLN sinuses was associated with accumulation of iron-laden Prussian blue positive macrophages in lymph nodes and synovium of Advanced TNF-Tg mice, and further validated in RA clinical samples. …”

Maternal β-catenin activity is hyperactivated in <i>nanog</i> mutant. by Mudan He (7017239)

“…<p>(A) western blot showing translation of Nanog protein totally disappeared in MZ<i>nanog</i>. …”

The iron-overload induced ferroptosis of TgCtwh3-infected HT-22 cells <i>in vitro</i> could be inhibited by DFP. by Chong Wang (120449)

“…<p>(A) Western blot analysis of 4-HNE and COX2 expression in the HT-22 cells uninfected and infected with the TgCtwh3. …”

Image_3_Multi-omics analysis identifies IgG2b class-switching with ALCAM-CD6 co-stimulation in joint-draining lymph nodes during advanced inflammatory-erosive arthritis.tif by H. Mark Kenney (10320665)

“…Integration of single-cell and spatial transcriptomics revealed the increased IgG2b⁺ plasma cells localized in MARCO⁺ peri-follicular medullary sinuses. A concomitant decreased Fth1 expression (Early 2.5 ± 0.74 vs Advanced 1.0 ± 0.50 counts, p<0.001) within Advanced PLN sinuses was associated with accumulation of iron-laden Prussian blue positive macrophages in lymph nodes and synovium of Advanced TNF-Tg mice, and further validated in RA clinical samples. …”

Fast Magnetization Tunneling in Tetranickel(II) Single-Molecule Magnets by En-Che Yang (2092804)

“…The exchange bias observed in the magnetization hysteresis loops of complexes <b>1</b> and <b>2</b> is dramatically decreased to zero in complex <b>3</b>, where the bulky dmb ligand is employed. …”

MiR-29b-2-5p, through repression of UNC5C expression, increases filopodia formation and <i>Shigella</i> capture by host cells. by Ushasree Sunkavalli (3916721)

“…Internalization and replication of <i>Shigella</i> within host cells lead to decreased levels of miR-29b-2-5p, which contributes to a balanced intracellular replication, avoiding premature cell death and favoring the efficient dissemination of <i>Shigella</i> to neighboring cells.…”

Sustained activation of β-catenin in the somatic cells leads to the induction of p53-mediated senescence in <i>Amhr2-Cre;Ctnnb1^Δ(ex3)/+</i> ovaries. by Pradeep S. Tanwar (143924)

“…Analyses also showed increased expression of pAKT and pS6K, and decreased expression of p21 and p27kip1 in <i>Amhr2-Cre;Ctnnb1^Δ(ex3)/+;Pten^Δ/Δ</i> ovaries. β-actin was used as a loading control. …”

Optical Activity and Dehydration-Driven Switching of Magnetic Properties in Enantiopure Cyanido-Bridged Co^II₃W^V₂ Trigonal Bipyramids by Szymon Chorazy (1396666)

“…The reversible removal of weakly bonded H₂O above 50 °C induces the structural phase transition <b>1</b> ⇄ <b>1deh</b> and strongly affects the magnetic characteristics. …”

Optical Activity and Dehydration-Driven Switching of Magnetic Properties in Enantiopure Cyanido-Bridged Co^II₃W^V₂ Trigonal Bipyramids by Szymon Chorazy (1396666)

“…The reversible removal of weakly bonded H₂O above 50 °C induces the structural phase transition <b>1</b> ⇄ <b>1deh</b> and strongly affects the magnetic characteristics. …”

Fast Magnetization Tunneling in Tetranickel(II) Single-Molecule Magnets by En-Che Yang (2092804)

“…The exchange bias observed in the magnetization hysteresis loops of complexes <b>1</b> and <b>2</b> is dramatically decreased to zero in complex <b>3</b>, where the bulky dmb ligand is employed. …”

Single-center retrospective study of the effectiveness and toxicity of the oral iron chelating drugs deferiprone and deferasirox by Nancy F. Olivieri (6407168)

“…The primary endpoint of monitoring in iron overload, hepatic iron concentration (HIC), increased (worsened) during deferiprone monotherapy (mean 10±2–18±2 mg/g; p < 0.0003), exceeding the threshold for life-threatening complications (15 mg iron/g liver) in 50% patients. During deferasirox monotherapy, mean HIC decreased (improved) (11±1–6±1 mg/g; p < 0.0001). …”

Data_Sheet_1_Early Changes in B and Plasma Cell Subsets and Traditional Serological Markers as Predictors of SRI-4 Response to Therapy in Systemic Lupus Erythematosus.docx by Ioannis Parodis (2851211)

“…</p>Results<p>In the analysis of the entire cohort, SRI-4 responders showed more prominent decreases from baseline through week 52 in CD19⁺CD20⁺CD27^– naïve B cells (median change: −61.2% versus −50.0%; P = 0.004), CD19⁺CD20^–CD27^bright plasmablasts (−44.9% versus −33.3%; P = 0.011), and CD19⁺CD20^–CD138⁺ long-lived plasma cells (−48.2% versus −37.1%; P = 0.024), and a more prominent rapid (+92.0% versus +66.7%; P = 0.002) and early (+60.0% versus +49.5%; P = 0.033) expansion of CD19⁺CD20⁺CD27⁺ memory B cells than non-responders. …”

Fast Magnetization Tunneling in Tetranickel(II) Single-Molecule Magnets by En-Che Yang (2092804)

“…The exchange bias observed in the magnetization hysteresis loops of complexes <b>1</b> and <b>2</b> is dramatically decreased to zero in complex <b>3</b>, where the bulky dmb ligand is employed. …”