Schematic representation of dsRNA- and virus-induced beta cell apoptosis. by Maikel L. Colli (179059)

“…<b>1</b>) Cytoplasmic dsRNA activates the kinase PKR that in turn phosphorylates the elongation factor eIF2α; <b>2</b>) phosphorylation of eIF2α leads to inhibition of protein translation with consequent decrease of Mcl-1 expression; <b>3</b>) reduction of Mcl-1 protein increases unbound Bim, which activates BAX; <b>4</b>) BAX translocates to the mitochondria; <b>5</b>) BAX oligomerizes and induces permeabilization of the mitochondrial outer membrane, allowing the release of cytochrome <i>c</i> to the cytoplasm; <b>6</b>) cytoplasmic cytochrome <i>c</i> forms complexes with Apaf1 and activates the initiator caspase 9; <b>7</b>) finally, caspase 9 cleaves and activates the executioner caspase 3, <b>8</b>) triggering the final steps of beta cell apoptosis; <b>9</b>) further studies are required to clarify additional pathways implicated in virus-induced beta cell apoptosis.…”

Fig 1 - by Leo Zeitler (13775500)

“…Mean nucleotide diversity (C) was reduced outside of the core, with a greater reduction for higher selfing: . Relative fitness (D) decreased from core to edge with similar values across outcrossers and selfers: , reflecting a relative loss of fitness as compared to the core of 29.1%, 29.8%, 32.4%, and 31.7% respectively for <i>σ</i> = 0, 0.5, 0.95, and 1.…”

SETX (senataxin), the helicase mutated in AOA2 and ALS4, functions in autophagy regulation by Patricia Richard (1341333)

Table10_Analysis of Genome-Wide Alternative Splicing Profiling and Development of Potential Drugs in Lung Adenocarcinoma.XLSX by Jing Song (188926)

“…Among them, NVP-AUY922 had the lowest IC50 value and might become a potential drug to prolong a patient’s survival. …”

Image4_Analysis of Genome-Wide Alternative Splicing Profiling and Development of Potential Drugs in Lung Adenocarcinoma.TIF by Jing Song (188926)

“…Among them, NVP-AUY922 had the lowest IC50 value and might become a potential drug to prolong a patient’s survival. …”

Table5_Analysis of Genome-Wide Alternative Splicing Profiling and Development of Potential Drugs in Lung Adenocarcinoma.DOCX by Jing Song (188926)

“…Among them, NVP-AUY922 had the lowest IC50 value and might become a potential drug to prolong a patient’s survival. …”

Image3_Analysis of Genome-Wide Alternative Splicing Profiling and Development of Potential Drugs in Lung Adenocarcinoma.TIF by Jing Song (188926)

“…Among them, NVP-AUY922 had the lowest IC50 value and might become a potential drug to prolong a patient’s survival. …”

Image2_Analysis of Genome-Wide Alternative Splicing Profiling and Development of Potential Drugs in Lung Adenocarcinoma.TIF by Jing Song (188926)

“…Among them, NVP-AUY922 had the lowest IC50 value and might become a potential drug to prolong a patient’s survival. …”

Data_Sheet_1_Engineering an in vitro retinothalamic nerve model.pdf by Giulia Amos (18587782)

“…Using embryonic rat retinas, we developed a model where retinal spheroids innervate thalamic targets through up to 6 mm long microfluidic channels. …”

Table6_Analysis of Genome-Wide Alternative Splicing Profiling and Development of Potential Drugs in Lung Adenocarcinoma.DOCX by Jing Song (188926)

“…Among them, NVP-AUY922 had the lowest IC50 value and might become a potential drug to prolong a patient’s survival. …”

Image1_Analysis of Genome-Wide Alternative Splicing Profiling and Development of Potential Drugs in Lung Adenocarcinoma.TIF by Jing Song (188926)

“…Among them, NVP-AUY922 had the lowest IC50 value and might become a potential drug to prolong a patient’s survival. …”

Table2_Analysis of Genome-Wide Alternative Splicing Profiling and Development of Potential Drugs in Lung Adenocarcinoma.DOCX by Jing Song (188926)

“…Among them, NVP-AUY922 had the lowest IC50 value and might become a potential drug to prolong a patient’s survival. …”

Table9_Analysis of Genome-Wide Alternative Splicing Profiling and Development of Potential Drugs in Lung Adenocarcinoma.XLSX by Jing Song (188926)

“…Among them, NVP-AUY922 had the lowest IC50 value and might become a potential drug to prolong a patient’s survival. …”

Table3_Analysis of Genome-Wide Alternative Splicing Profiling and Development of Potential Drugs in Lung Adenocarcinoma.DOCX by Jing Song (188926)

“…Among them, NVP-AUY922 had the lowest IC50 value and might become a potential drug to prolong a patient’s survival. …”

Table11_Analysis of Genome-Wide Alternative Splicing Profiling and Development of Potential Drugs in Lung Adenocarcinoma.XLSX by Jing Song (188926)

“…Among them, NVP-AUY922 had the lowest IC50 value and might become a potential drug to prolong a patient’s survival. …”

Table1_Analysis of Genome-Wide Alternative Splicing Profiling and Development of Potential Drugs in Lung Adenocarcinoma.DOCX by Jing Song (188926)

“…Among them, NVP-AUY922 had the lowest IC50 value and might become a potential drug to prolong a patient’s survival. …”

Image5_Analysis of Genome-Wide Alternative Splicing Profiling and Development of Potential Drugs in Lung Adenocarcinoma.TIF by Jing Song (188926)

“…Among them, NVP-AUY922 had the lowest IC50 value and might become a potential drug to prolong a patient’s survival. …”

Table7_Analysis of Genome-Wide Alternative Splicing Profiling and Development of Potential Drugs in Lung Adenocarcinoma.XLSX by Jing Song (188926)

“…Among them, NVP-AUY922 had the lowest IC50 value and might become a potential drug to prolong a patient’s survival. …”

Table8_Analysis of Genome-Wide Alternative Splicing Profiling and Development of Potential Drugs in Lung Adenocarcinoma.XLSX by Jing Song (188926)

“…Among them, NVP-AUY922 had the lowest IC50 value and might become a potential drug to prolong a patient’s survival. …”

Table4_Analysis of Genome-Wide Alternative Splicing Profiling and Development of Potential Drugs in Lung Adenocarcinoma.DOCX by Jing Song (188926)

“…Among them, NVP-AUY922 had the lowest IC50 value and might become a potential drug to prolong a patient’s survival. …”