Genetic and Metabolomic Dissection of the Ergothioneine and Selenoneine Biosynthetic Pathway in the Fission Yeast, <i>S. pombe</i>, and Construction of an Overproduction System by Tomáš Pluskal (475361)

“…Among deletion mutants of these genes, only one (Δ<i>SPBC660.12c</i>, designated Δ<i>egt2</i>) showed a substantial decrease in ergothioneine, accompanied by accumulation of its immediate precursor, hercynylcysteine sulfoxide. …”

Pcl3 promotes ESC self-renewal. by Julie Hunkapiller (177548)

“…Graph represents average expression from 3–6 different clones. (B) A portion of cells transduced with <i>Pcl3</i> shRNA, but not scramble shRNA, are larger, flatter, and less dense, signifying a decrease in ESC cell morphology. …”

Receptive field area_nyxnob.xlsx by Maj-Britt Hölzel (6938768)

Table 1_Effect of cholecalciferol on immune and vascular function in non-diabetic chronic kidney disease.docx by Kajal Kamboj (12769602)

“…The mean age was 44 ± 12 years with 58% men. TH1 cells decreased from 17% (9%, 27%) to 11% (6%, 16%) (p=0.002) and TH2 cells increased from 9% (5%, 16%) to 16% (10%, 27%) (p=0.001) after cholecalciferol treatment. …”

Neurite degeneration following si<i>Nmnat2</i> injection precedes loss of neuronal viability. by Jonathan Gilley (126469)

“…<p>(A) Viability of wild-type SCG neurons injected with non-targeting siRNA (si<i>Control</i>) or <i>Nmnat2</i> siRNA (si<i>Nmnat2</i>), together with pEGFP-C1 (10 ng/µl), and treated with 50 µM z-VAD-fmk or vehicle (DMSO) as indicated. …”

Erratum: The Polyketide Synthase-Associated Multidrug Tolerance in <b><i>Mycobacterium intracellulare</i></b> Clinical Isolates by Matsunaga I. (4273081)

Role of ecto-NDPK on eATP dynamics. by Nicolas Andres Saffioti (16469951)

“…<p>(A) The plot shows the experimental results of eATP dynamics in the presence of 100 μM eCTP and various [eADP] (also shown in <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1011196#pcbi.1011196.g003" target="_blank">Fig 3A</a>). …”

Interaction of the mTERT telomerase catalytic subunit with the c-Abl tyrosine kinase in mouse granulosa cells by Aylin Yaba (85232)

Analysis of elytra for chitin levels following RNAi for <i>CPAP</i> genes. by Sinu Jasrapuria (116965)

“…<p>(A and B) Biochemical analysis of chitin content of 5 day-old pupae was carried out using a modified Morgan–Elson method (n = 5) <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0049844#pone.0049844-Arakane1" target="_blank">[11]</a>. …”

Tuning of Msn2 expression in rapidly growing cells. by Michal Chapal (7961111)

“…(F–G) Noisy Msn2 expression decreases stress protection and growth rate: we generated six strains with Msn2-YFP expressed under different promoters, which control genes with noisier expression than Msn2 but have a similar mean abundance (mean abundance in <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.3000289#pbio.3000289.s005" target="_blank">S5 Fig</a>), and deletion of <i>MSN4</i>. …”

DataSheet1_Adolescent Binge Alcohol Enhances Early Alzheimer’s Disease Pathology in Adulthood Through Proinflammatory Neuroimmune Activation.zip by Alexandra Barnett (12458778)

“…Both heavy alcohol use and AD feature increased proinflammatory signaling. Therefore, we hypothesized that adolescent binge ethanol would increase AD molecular and behavioral pathology in adulthood through proinflammatory signaling. …”

Image4_Validation of potential RNA biomarkers for prostate cancer diagnosis and monitoring in plasma and urinary extracellular vesicles.PNG by Agnese Brokāne (14561396)

“…Next, the results were validated in an independent cohort of plasma EVs from 31 PCa and 31 BPH patients.</p><p>Results: We found that the levels of NKX3-1 (p = 0.0008) in plasma EVs, and tRF-Phe-GAA-3b (p < 0.0001) tRF-Lys-CTT-5c (p < 0.0327), piR-28004 (p = 0.0081) and miR-375-3p (p < 0.0001) in urinary EVs significantly decreased after radical prostatectomy suggesting that the main tissue source of these RNAs is prostate and/or PCa. …”

Table1_Validation of potential RNA biomarkers for prostate cancer diagnosis and monitoring in plasma and urinary extracellular vesicles.DOCX by Agnese Brokāne (14561396)

“…Next, the results were validated in an independent cohort of plasma EVs from 31 PCa and 31 BPH patients.</p><p>Results: We found that the levels of NKX3-1 (p = 0.0008) in plasma EVs, and tRF-Phe-GAA-3b (p < 0.0001) tRF-Lys-CTT-5c (p < 0.0327), piR-28004 (p = 0.0081) and miR-375-3p (p < 0.0001) in urinary EVs significantly decreased after radical prostatectomy suggesting that the main tissue source of these RNAs is prostate and/or PCa. …”

<i>Lin28B</i> Is an Oncofetal Circulating Cancer Stem Cell-Like Marker Associated with Recurrence of Hepatocellular Carcinoma by Shu-Wen Cheng (484650)

“…<div><p>By using an expressed sequence tag bioinformatic algorithm, we identified that <i>Lin28 homolog B</i> (<i>Lin28B</i>) may have an oncofetal expression pattern which may facilitate detecting cancer cells in adults. …”

Image2_Validation of potential RNA biomarkers for prostate cancer diagnosis and monitoring in plasma and urinary extracellular vesicles.PNG by Agnese Brokāne (14561396)

“…Next, the results were validated in an independent cohort of plasma EVs from 31 PCa and 31 BPH patients.</p><p>Results: We found that the levels of NKX3-1 (p = 0.0008) in plasma EVs, and tRF-Phe-GAA-3b (p < 0.0001) tRF-Lys-CTT-5c (p < 0.0327), piR-28004 (p = 0.0081) and miR-375-3p (p < 0.0001) in urinary EVs significantly decreased after radical prostatectomy suggesting that the main tissue source of these RNAs is prostate and/or PCa. …”

Image3_Validation of potential RNA biomarkers for prostate cancer diagnosis and monitoring in plasma and urinary extracellular vesicles.PNG by Agnese Brokāne (14561396)

“…Next, the results were validated in an independent cohort of plasma EVs from 31 PCa and 31 BPH patients.</p><p>Results: We found that the levels of NKX3-1 (p = 0.0008) in plasma EVs, and tRF-Phe-GAA-3b (p < 0.0001) tRF-Lys-CTT-5c (p < 0.0327), piR-28004 (p = 0.0081) and miR-375-3p (p < 0.0001) in urinary EVs significantly decreased after radical prostatectomy suggesting that the main tissue source of these RNAs is prostate and/or PCa. …”

Upregulation of polycistronic microRNA-143 and microRNA-145 in colonocytes suppresses colitis and inflammation-associated colon cancer by Urszula Dougherty (9920988)

“…<p>Because ADAM17 promotes colonic tumorigenesis, we investigated potential miRNAs regulating ADAM17; and examined effects of diet and tumorigenesis on these miRNAs. …”

Image1_Validation of potential RNA biomarkers for prostate cancer diagnosis and monitoring in plasma and urinary extracellular vesicles.PNG by Agnese Brokāne (14561396)

“…Next, the results were validated in an independent cohort of plasma EVs from 31 PCa and 31 BPH patients.</p><p>Results: We found that the levels of NKX3-1 (p = 0.0008) in plasma EVs, and tRF-Phe-GAA-3b (p < 0.0001) tRF-Lys-CTT-5c (p < 0.0327), piR-28004 (p = 0.0081) and miR-375-3p (p < 0.0001) in urinary EVs significantly decreased after radical prostatectomy suggesting that the main tissue source of these RNAs is prostate and/or PCa. …”

Supplementary file 1_Impact of natural and socio-economic factors on varicella incidence in children in Shanghai, 2013-2022.pdf by Chunmei Duan (9024560)

“…Following the two-dose VarV program’s introduction, the incidence rate decreased by 0.49 cases per 100,000 per month, with an impressive 79.10% reduction in the annual average incidence among children aged 4–6 years. …”

T-cell priming in DC/T-cell co-culture. WT and Lcn2^−/− DCs were pre-treated for 6 h with LPS and then co-cultured with T-cells. by Melanie Floderer (596361)

“…(B) Analysis of the T-cell apoptosis at 1∶1 (10⁵∶10⁵), 1∶5 (2×10⁴∶10⁵) and 1∶10 (10⁴∶10⁵) DC/T-cell ratios. …”