Image_3_Empagliflozin Induces White Adipocyte Browning and Modulates Mitochondrial Dynamics in KK Cg-Ay/J Mice and Mouse Adipocytes.TIF by Linxin Xu (4506865)

“…Empagliflozin has emerged as an agent with weight-loss potential in clinical and in vivo studies, but the mechanisms underlying its effect are not fully understood. Here, we investigated whether empagliflozin could induce WAT browning and mitochondrial alterations in KK Cg-Ay/J (KKAy) mice, and explored the mechanisms of its effects.…”

Image_4_Empagliflozin Induces White Adipocyte Browning and Modulates Mitochondrial Dynamics in KK Cg-Ay/J Mice and Mouse Adipocytes.TIF by Linxin Xu (4506865)

“…Empagliflozin has emerged as an agent with weight-loss potential in clinical and in vivo studies, but the mechanisms underlying its effect are not fully understood. Here, we investigated whether empagliflozin could induce WAT browning and mitochondrial alterations in KK Cg-Ay/J (KKAy) mice, and explored the mechanisms of its effects.…”

Table1_Techno Commercial Analysis of Liquefied Petroleum Gas Recovery From Natural Gas Using Aspen HYSYS.docx by Usman Ali (6586886)

“…Case study 3 shows a maximum decrease in hot side utilities in the flowsheet of about 20% while 10 and 14% decreases are observed for case studies 1 and 2, respectively. …”

<i>Spidey</i> is essential for cuticular lipid synthesis in adult flies. by Yin Ning Chiang (1718815)

“…Data represent the mean intensity of 3 experimental replicates (8 flies each) ± SEM; Student’s t-test, *p<0.05; a.u.: arbitrary units. See <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1006126#pgen.1006126.s012" target="_blank">S6 Table</a> for full genotypes. …”

Putative Cbf11-regulated lipid metabolism genes. by Martin Převorovský (209870)

“…<p><b>(A)</b> The mRNA levels at each condition relative to the levels in wild-type control cells are colour-coded as indicated at top right, with missing data in grey; for description of cultivation conditions see legend to <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0137820#pone.0137820.g001" target="_blank">Fig 1A</a>. …”

Sholl analysis and spine density analysis in mouse hippocampal neurons. by Qiang-qiang Xia (8060987)

“…D) Sholl analysis of WT and <i>Cul3</i> HET knockouts demonstrates decreased dendritic branching in <i>Cul3</i> HET mutant neurons, a main effect of genotype was observed (P = 0.002, WT N = 30/10 cells/mice; HET N = 30/10). …”

Attempt to Clarify the Synergistic Effect Mechanism of Clathrate Hydrate Crystal Growth Inhibitors by Michihiro Muraoka (1354683)

“…Our previous study proposed using the degree of supercooling of the growth interface, Δ<i>T</i>, as an HCGI inhibition performance index with a relatively low growth rate, <i>V</i>, in the region ≤10 μm s^–1. …”

Attempt to Clarify the Synergistic Effect Mechanism of Clathrate Hydrate Crystal Growth Inhibitors by Michihiro Muraoka (1354683)

“…Our previous study proposed using the degree of supercooling of the growth interface, Δ<i>T</i>, as an HCGI inhibition performance index with a relatively low growth rate, <i>V</i>, in the region ≤10 μm s^–1. …”

Data_Sheet_1_Antioxidant and Anti-atherogenic Properties of Prosopis strombulifera and Tessaria absinthioides Aqueous Extracts: Modulation of NADPH Oxidase-Derived Reactive Oxygen... by Isabel Quesada (11144235)

“…In VSMCs, both extracts (5–40 μg/ml) inhibited 10% fetal calf serum-induced cell proliferation, arrested cell in G2/M phase, reduced angiotensin II-induced reactive oxygen species (ROS) generation, and decreased NADPH oxidase subunit expression. …”

Workflow of designed analysis. by Changlong Yang (8392152)

“…</p><p>Results</p><p>Our analysis provided compelling evidence for the causal association of higher genetically predicted eosinophil cell count (EOS, odds ratio [OR], 0.8639; 95% confidence interval [CI] 0.7922–0.9421) and red cell distribution width (RDW, OR, 0.9981; 95% CI, 0.9972–0.9989) levels with a decreased risk of CRC. Additionally, we found suggestive evidence indicating that higher levels of total cholesterol (TC, OR, 1.0022; 95% CI, 1.0002–1.0042) may increase the risk of CRC. …”

S1 File - by Changlong Yang (8392152)

“…</p><p>Results</p><p>Our analysis provided compelling evidence for the causal association of higher genetically predicted eosinophil cell count (EOS, odds ratio [OR], 0.8639; 95% confidence interval [CI] 0.7922–0.9421) and red cell distribution width (RDW, OR, 0.9981; 95% CI, 0.9972–0.9989) levels with a decreased risk of CRC. Additionally, we found suggestive evidence indicating that higher levels of total cholesterol (TC, OR, 1.0022; 95% CI, 1.0002–1.0042) may increase the risk of CRC. …”

S3 File - by Changlong Yang (8392152)

“…</p><p>Results</p><p>Our analysis provided compelling evidence for the causal association of higher genetically predicted eosinophil cell count (EOS, odds ratio [OR], 0.8639; 95% confidence interval [CI] 0.7922–0.9421) and red cell distribution width (RDW, OR, 0.9981; 95% CI, 0.9972–0.9989) levels with a decreased risk of CRC. Additionally, we found suggestive evidence indicating that higher levels of total cholesterol (TC, OR, 1.0022; 95% CI, 1.0002–1.0042) may increase the risk of CRC. …”

S2 File - by Changlong Yang (8392152)

“…</p><p>Results</p><p>Our analysis provided compelling evidence for the causal association of higher genetically predicted eosinophil cell count (EOS, odds ratio [OR], 0.8639; 95% confidence interval [CI] 0.7922–0.9421) and red cell distribution width (RDW, OR, 0.9981; 95% CI, 0.9972–0.9989) levels with a decreased risk of CRC. Additionally, we found suggestive evidence indicating that higher levels of total cholesterol (TC, OR, 1.0022; 95% CI, 1.0002–1.0042) may increase the risk of CRC. …”

Data_Sheet_1_Enhancing pathogen description and antibiotic regimen selection in community-acquired pneumonia through RT-qPCR assays.doc by Na Zhao (112953)

“…It showed potential in optimizing antimicrobial prescriptions by allowing for de-escalation in 18.30% (95/518) of patients, among which reducing the number of excessive antibiotics mainly comprised decreasing the use of 2nd or 3rd generation cephalosporins (5.79%, 30/518) and β-lactamase inhibitor combinations.…”

Data_Sheet_1_Modeling Current and Future Potential Distributions of Milkweeds and the Monarch Butterfly in Idaho.docx by Leona K. Svancara (6705392)

“…Models project slight decreases (−1,318 km²) in potential suitable habitat for showy milkweed and significant increases (+5,830 km²) for swamp milkweed. …”

S4 File - by Changlong Yang (8392152)

“…</p><p>Results</p><p>Our analysis provided compelling evidence for the causal association of higher genetically predicted eosinophil cell count (EOS, odds ratio [OR], 0.8639; 95% confidence interval [CI] 0.7922–0.9421) and red cell distribution width (RDW, OR, 0.9981; 95% CI, 0.9972–0.9989) levels with a decreased risk of CRC. Additionally, we found suggestive evidence indicating that higher levels of total cholesterol (TC, OR, 1.0022; 95% CI, 1.0002–1.0042) may increase the risk of CRC. …”

TRAIL attenuates RANKL-mediated osteoblastic signalling in vascular cell mono-culture and co-culture models by Emma Harper (4597789)

“…Moreover, within these contexts we present clear evidence that TRAIL can block several key signalling actions of RANKL in vascular cells, providing further evidence of its vasoprotective potential.…”

Per cent of total land area in each land cover category over time within the study area by M E Fagan (557038)

Macroscopic phenotype of <i>Dmp1/Klotho</i> compound deficient mice (<i>Dmp1^−/−kl/kl</i>). by Afsaneh Rangiani (145318)

“…(<b>B</b>) Body weights of 6 weeks old mice, showing a decrease in <i>Dmp1^−/−</i> (13%), <i>kl/kl</i> (57%) and <i>Dmp1^−/−kl/kl</i> (36%) mice compared to the age matched WT (P = 0.02; P<0.001, and P<0.001 respectively; n = 10 in each group). …”

Table_2_Reactive Jumps Preserve Skeletal Muscle Structure, Phenotype, and Myofiber Oxidative Capacity in Bed Rest.xlsx by Dieter Blottner (174858)

“…In VL, bed rest only induced capillary rarefaction, as reflected by the decrease in local capillary-to-fiber ratio (LCFR) for both type II (pre vs. post/R + 10, p = 0.028/0.028) and type I myofibers (pre vs. …”