Presentation_1_Treatment of in vitro-Matured Bovine Oocytes With Tauroursodeoxycholic Acid Modulates the Oxidative Stress Signaling Pathway.pdf by Elisa Mariano Pioltine (10165832)

“…Interestingly, high concentration of TUDCA (1,000 μM) was toxic to oocytes, reducing the nuclear maturation rate, decreasing mitochondrial activity, and increasing the abundance of ER stress (HSPA5) and cellular apoptosis (CASP3 and CD40) related transcripts. …”

Amplitude-modulated sinusoidal microchannels for observing adaptability in C. elegans locomotion by Santosh Pandey (12981308)

Zn_<i>x</i>Mn_1–<i>X</i>Fe₂O₄@SiO₂:<i>z</i>Nd³⁺ Core–Shell Nanoparticles for Low-Field Magnetic Hyperthermia and Enh... by Marcus Vinícius-Araújo (10096489)

“…Multifunctional magnetic nanoparticles (NPs) that can generate and monitor heat (in real-time) during thermal therapy are a major challenge in nanomedicine. Here, we report a trimodal system combining magnetic NP hyperthermia (MNH), photothermal therapy (PTT), and luminescent nanothermometry (LNT) properties with an all-in-one nanoplatform. …”

Zn_<i>x</i>Mn_1–<i>X</i>Fe₂O₄@SiO₂:<i>z</i>Nd³⁺ Core–Shell Nanoparticles for Low-Field Magnetic Hyperthermia and Enh... by Marcus Vinícius-Araújo (10096489)

“…Multifunctional magnetic nanoparticles (NPs) that can generate and monitor heat (in real-time) during thermal therapy are a major challenge in nanomedicine. Here, we report a trimodal system combining magnetic NP hyperthermia (MNH), photothermal therapy (PTT), and luminescent nanothermometry (LNT) properties with an all-in-one nanoplatform. …”

Zn_<i>x</i>Mn_1–<i>X</i>Fe₂O₄@SiO₂:<i>z</i>Nd³⁺ Core–Shell Nanoparticles for Low-Field Magnetic Hyperthermia and Enh... by Marcus Vinícius-Araújo (10096489)

“…Multifunctional magnetic nanoparticles (NPs) that can generate and monitor heat (in real-time) during thermal therapy are a major challenge in nanomedicine. Here, we report a trimodal system combining magnetic NP hyperthermia (MNH), photothermal therapy (PTT), and luminescent nanothermometry (LNT) properties with an all-in-one nanoplatform. …”

Protein disulfide isomerases (PDIs) negatively regulate ebolavirus structural glycoprotein expression in the endoplasmic reticulum (ER) via the autophagy-lysosomal pathway by Bin Wang (30851)

“…</p> <p><b>Abbreviations:</b> 3-MA: 3-methyladenine; 4-PBA: 4-phenylbutyrate; ACTB: β-actin; ATF: activating transcription factor; ATG: autophagy-related; BafA1: bafilomycin A₁; BDBV: <i>Bundibugyo</i> ebolavirus; CALR: calreticulin; CANX: calnexin; CHX: cycloheximide; CMA: chaperone-mediated autophagy; ConA: concanamycin A; CRISPR: clusters of regularly interspaced short palindromic repeats; Cas9: CRISPR-associated protein 9; dsRNA: double-stranded RNA; EBOV: <i>Zaire</i> ebolavirus; EDEM: ER degradation enhancing alpha-mannosidase like protein; EIF2AK3/PERK: eukaryotic translation initiation factor 2 alpha kinase 3; Env: envelope glycoprotein; ER: endoplasmic reticulum; ERAD: ER-associated protein degradation; ERN1/IRE1: endoplasmic reticulum to nucleus signaling 1; GP: glycoprotein; HA: hemagglutinin; HDAC6: histone deacetylase 6; HMM: high-molecular-mass; HIV-1: human immunodeficiency virus type 1; HSPA5/BiP: heat shock protein family A (Hsp70) member 5; IAV: influenza A virus; IP: immunoprecipitation; KIF: kifenesine; Lac: lactacystin; LAMP: lysosomal associated membrane protein; MAN1B1/ERManI: mannosidase alpha class 1B member 1; MAP1LC3/LC3: microtubule associated protein 1 light chain 3; MARV: Marburg virus; MLD: mucin-like domain; NHK/SERPINA1: alpha1-antitrypsin variant null (Hong Kong); NTZ: nitazoxanide; PDI: protein disulfide isomerase; RAVV: Ravn virus; RESTV: Reston ebolavirus; SARS-CoV: severe acute respiratory syndrome coronavirus; SBOV: <i>Sudan</i> ebolavirus; sGP: soluble GP; SQSTM1/p62: sequestosome 1; ssGP: small soluble GP; TAFV: Taï Forest ebolavirus; TIZ: tizoxanide; TGN: thapsigargin; TLD: TXN (thioredoxin)-like domain; Ub: ubiquitin; UPR: unfolded protein response; VLP: virus-like particle; VSV: vesicular stomatitis virus; WB: Western blotting; WT: wild-type; XBP1: X-box binding protein 1.…”

Data_Sheet_1_Reducing culture medium nitrogen supply coupled with replenishing carbon nutrient simultaneously enhances the biomass and lipid production of Chlamydomonas reinhardtii... by Shiyan Zheng (13860734)

“…<p>Chlamydomonas reinhardtii is a model strain to explore algal lipid metabolism mechanism, and exhibits great potentials in large-scale production of lipids. …”

Data_Sheet_1_Mixotrophic Growth of Chlorella sorokiniana on Acetate and Butyrate: Interplay Between Substrate, C:N Ratio and pH.docx by Julien Lacroux (11064543)

“…However, VFA concentration strongly affected biomass yields irrespective of pH control or C:N:P ratios. Biomass yields on 1.0 g_C.L^–1 acetate were around 1.3-1.5 g_C.g_C^–1 but decreased by 26-48% when increasing initial acetate to 2.0 g_C.L^–1. …”

Table 1_Dietary phosphorus restriction induced phospholipid deficiency, endoplasmic reticulum stress, inflammatory response and gut microbiota disorders in Lateolabrax maculatus.do... by Zixiang Wu (312334)

“…In contrast to fish fed the NP diet, fish fed the LP diet exhibited a decrease in the abundance of potential metabolically promoted probiotics (e.g., Lactococcus lactis) and an increase in the abundance of potential pathogenic bacteria (e.g., Plesiomonas) in the gut. …”

DataSheet_1_Effects of the neurotoxin β-N-methylamino-L-alanine (BMAA) on the early embryonic development of marine shellfish and fish.docx by Yilei Fu (14287574)

“…Based on the dose-response curves related to the modified malformation rate of embryos, the median effective concentration (EC₅₀) values of mussel (48 h) and oyster (24 h) embryos were 196 μg BMAA·HCl/L (1.27 µM) and 1660 μg BMAA·HCl/L (10.7 μM), respectively. A sustained and dose-dependent decrease in heart rate was apparent in marine medaka embryos at 9-days post fertilization following BMAA exposure. …”

Table 2_Dietary phosphorus restriction induced phospholipid deficiency, endoplasmic reticulum stress, inflammatory response and gut microbiota disorders in Lateolabrax maculatus.do... by Zixiang Wu (312334)

“…In contrast to fish fed the NP diet, fish fed the LP diet exhibited a decrease in the abundance of potential metabolically promoted probiotics (e.g., Lactococcus lactis) and an increase in the abundance of potential pathogenic bacteria (e.g., Plesiomonas) in the gut. …”

DataSheet1_Evaluation of Kratom Opioid Derivatives as Potential Treatment Option for Alcohol Use Disorder.PDF by Anna M. Gutridge (9852364)

“…Paynantheine did not produce robust antinociception but did block morphine-induced antinociception and hyperlocomotion. Yet, at 10 and 30 mg∙kg⁻¹ doses (i.p.), paynantheine did not counteract morphine CPP. 7-hydroxypaynantheine and 7-hydroxyspeciogynine displayed potency at δOR but limited µOR potency relative to 7-hydroxymitragynine in vitro, and dose-dependently decreased voluntary alcohol consumption in WT but not δOR in KO mice. 7-hydroxyspeciogynine has a maximally tolerated dose of at least 10 mg∙kg⁻¹ (s.c.) at which it did not produce significant CPP neither alter general locomotion nor induce noticeable seizures.…”

Supplementary Material for: Panax Quinquefolium Saponins Attenuate Myocardial Dysfunction Induced by Chronic Ischemia by Guo M. (5561081)

“…Myocyte diameter was decreased. PQS also attenuated the CMI-induced change of protein expression profile. …”

Table_1_Oral Supplementation of Lead-Intolerant Intestinal Microbes Protects Against Lead (Pb) Toxicity in Mice.docx by Qixiao Zhai (830803)

“…Supplementation with O. ruminantium significantly decreased Pb concentrations in blood (from 152.70 ± 25.62 μg/dL to 104.60 ± 29.85 μg/dL) and kidney (from 7.30 ± 1.08 μg/g to 5.64 ± 0.79 μg/g). …”

Data_Sheet_1_How do teacher support trajectories influence primary and lower-secondary school students’ study well-being.docx by Sanna Ulmanen (16875168)

“…LGM revealed four latent trajectories for teacher support, which were labeled high stable (72%), low stable (12%), decreasing (11%) and increasing (5%). The teacher support trajectories were strongly associated with students’ study engagement and study burnout. …”

DataSheet_1_An Immunological Perspective: What Happened to Pregnant Women After Recovering From COVID-19?.docx by Sijia Zhao (7301039)

“…There is no clear consistent evidence of the changes in the immune status of pregnant women after recovery from COVID-19. In this study, we use multiparameter flow cytometry and Luminex assay to determine the immune cell subsets and cytokines, respectively, in the peripheral blood and umbilical cord blood from pregnant women recovering from COVID-19 about 3 months (n=5). …”

Table_2_Oral Supplementation of Lead-Intolerant Intestinal Microbes Protects Against Lead (Pb) Toxicity in Mice.docx by Qixiao Zhai (830803)

“…Supplementation with O. ruminantium significantly decreased Pb concentrations in blood (from 152.70 ± 25.62 μg/dL to 104.60 ± 29.85 μg/dL) and kidney (from 7.30 ± 1.08 μg/g to 5.64 ± 0.79 μg/g). …”

An adenylyl cyclase like-9 gene (<i>NlAC9</i>) influences growth and fecundity in the brown planthopper, <i>Nilaparvata lugens</i> (Stål) (Hemiptera: Delphacidae) by LinQuan Ge (4683439)

“…<div><p>The cAMP/PKA intracellular signaling pathway is launched by adenylyl cyclase (AC) conversion of adenosine triphosphate (ATP) to 3', 5'-cyclic AMP (cAMP) and cAMP-dependent activation of PKA. …”

Drug Absorption Efficiency in <em>Caenorhbditis elegans</em> Delivered by Different Methods by Shan-Qing Zheng (382120)

“…</p> <p>Methodology/Principal Findings</p><p>We evaluated the drug absorption efficiency in <i>C. elegans</i> using five frequently used methods with resveratrol with low aqueous solubility and water-soluble 5-Fluoro-2′-deoxyuridine (FUDR) as positive compounds. …”

Simplified schematic depicting the proposed mechanism underlying the adolescent intermittent ethanol (AIE)-induced loss of basal forebrain cholinergic neurons. by Ryan P. Vetreno (663148)

“…Interestingly, LPS treatment has previously been found to decrease hippocampal expression of the neurotrophin nerve growth factor (NGF) [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0204500#pone.0204500.ref055" target="_blank">55</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0204500#pone.0204500.ref056" target="_blank">56</a>], which is critical for basal forebrain cholinergic maintenance and survival [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0204500#pone.0204500.ref010" target="_blank">10</a>]. …”