DataSheet_3_Increased Expression of Mitochondrial UQCRC1 in Pancreatic Cancer Impairs Antitumor Immunity of Natural Killer Cells via Elevating Extracellular ATP.docx by Hui Cong (3909211)

“…Such UQCRC1-induced impairment of NK cells was mediated by eATP and its metabolite adenosine via P2Y11R and A_2AR, respectively. Mechanistically, we found the UQCRC1/eATP axis reduced the expression of chemokine CCL5 in cancer cells and altered the balance of activating receptor DNAM-1 and inhibitory receptor CD96 on NK-92MI cells, resulting in decreased chemotaxis and exhausted phenotype of NK-92MI cells. …”

Impact of Transcatheter Aortic Valve Implantation on Kidney Function by Rita Calça (7888694)

“…We analyzed the eGFR one month and one year after TAVI in these three groups, using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) formula to calculate it. …”

Data_Sheet_2_A Phosphoproteomics Study of the Soybean root necrosis 1 Mutant Revealed Type II Metacaspases Involved in Cell Death Pathway.docx by Feifei Wang (195514)

“…We identified 3,160 proteins. When the p-value was set at ≤0.05 and the fold change of protein accumulation between rn1 and T322 at ≥1.5 or ≤0.67, we detected 118 proteins that showed increased levels and 32 proteins decreased levels in rn1 as compared to that in T322. …”

Functional Trait Strategies of Trees in Dry and Wet Tropical Forests Are Similar but Differ in Their Consequences for Succession by Madelon Lohbeck (731258)

“…Species turnover with succession in dry forest largely relates to increasing water availability and in wet forest to decreasing light availability. We hypothesized that while functional trait trade-offs are similar in the two forest systems, the successful plant strategies in these communities will be different, as contrasting filters affect species turnover. …”

Dissecting <em>Phaseolus vulgaris</em> Innate Immune System against <em>Colletotrichum lindemuthianum</em> Infection by Paula Rodrigues Oblessuc (141400)

“…Based on experimental validation of gene expression, we propose that hypersensitive reaction as part of effector-triggered immunity may operate, at least in part, by down-regulating genes, such as <em>FLS2-like</em> and <em>MKK5-like</em>, putative orthologs of the Arabidopsis genes involved in pathogen perception and downstream signaling.…”

Table 1_Epigenetic age acceleration and neurotrophin signaling pathways in cancer-related cognitive impairment: a longitudinal, prospective cohort study.docx by Michael Sayer (11493436)

“…</p>Results<p>PhenoAge and GrimAge demonstrated significant age acceleration relative to non-cancer controls and worsening cognitive function symptoms, with accelerated GrimAge associated with decreasing BDNF levels. DMPs associated with 5 different cognitive function outcomes (FactCog Score, Response, Memory, Executive Function, Multi-Tasking) were mapped to genes within KEGG pathway HSA:04722 (Neurotrophin Signaling Pathway). …”

DataSheet_1_Soluble CD83 modulates human-monocyte-derived macrophages toward alternative phenotype, function, and metabolism.docx by Katrin Peckert-Maier (13211658)

“…We show that sCD83 strikingly increases the expression of inhibitory molecules including ILT-2 (immunoglobulin-like transcript 2), ILT-4, ILT-5, and CD163, whereas activation markers, such as MHC-II and MSR-1, were significantly downregulated. …”

Senescence Is More Important in the Natural Lives of Long- Than Short-Lived Mammals by Christopher Turbill (244271)

“…The slope of this relationship (0.353±0.052 s.e.m.), however, indicated that mammals with higher survival rates have a mean life span representing a greater fraction of their potential maximum life span: the ratio of maximum to mean life span decreased significantly from >10 in short-lived to ∼1.5 in long-lived mammal species.…”

Targeted Resequencing of the Pericentromere of Chromosome 2 Linked to Constitutional Delay of Growth and Puberty by Diana L. Cousminer (747917)

“…One gene, <i>DNAH6</i>, harbored 6 protein-altering low-frequency variants (< 6% in the Finnish population) in 10 of the CDGP probands. We sequenced an additional 135 unrelated Finnish CDGP subjects and utilized the unique Sequencing Initiative Suomi (SISu) population reference exome set to show that while 5 of these variants were present in the CDGP set, they were also present in the Finnish population at similar frequencies. …”

Table 2_Epigenetic age acceleration and neurotrophin signaling pathways in cancer-related cognitive impairment: a longitudinal, prospective cohort study.docx by Michael Sayer (11493436)

“…</p>Results<p>PhenoAge and GrimAge demonstrated significant age acceleration relative to non-cancer controls and worsening cognitive function symptoms, with accelerated GrimAge associated with decreasing BDNF levels. DMPs associated with 5 different cognitive function outcomes (FactCog Score, Response, Memory, Executive Function, Multi-Tasking) were mapped to genes within KEGG pathway HSA:04722 (Neurotrophin Signaling Pathway). …”

Data Sheet 2_Epigenetic age acceleration and neurotrophin signaling pathways in cancer-related cognitive impairment: a longitudinal, prospective cohort study.csv by Michael Sayer (11493436)

“…</p>Results<p>PhenoAge and GrimAge demonstrated significant age acceleration relative to non-cancer controls and worsening cognitive function symptoms, with accelerated GrimAge associated with decreasing BDNF levels. DMPs associated with 5 different cognitive function outcomes (FactCog Score, Response, Memory, Executive Function, Multi-Tasking) were mapped to genes within KEGG pathway HSA:04722 (Neurotrophin Signaling Pathway). …”

Experimental verification of model predictions. by Mphatso Kalemera (6476033)

“…We used the model to predict the outcome of the experiment; in 3.2x CD81 over-expressing cells we expect that complete blockade of SR-B1 inhibits infection by ~50%, compared to ~80% inhibition for unmodified cells. …”

DataSheet1_A novel hybrid bioprocess strategy addressing key challenges of advanced biomanufacturing.PDF by Lucas Nik Reger (14632742)

“…In addition, we could demonstrate scalability of the process to a 5L benchtop system, using a fluidized-bed centrifuge as scalable media exchange system. …”

Presentation_1.pdf by Behzad Bidadi (4953235)

“…<p>Neutropenia secondary to chemotherapy in breast cancer patients can be life-threatening and there are no biomarkers available to predict the risk of drug-induced neutropenia in those patients. We previously performed a genome-wide association study (GWAS) for neutropenia events in women with breast cancer who were treated with 5-fluorouracil, epirubicin and cyclophosphamide and recruited to the SUCCESS-A trial. …”

DataSheet_1_Increased Expression of Mitochondrial UQCRC1 in Pancreatic Cancer Impairs Antitumor Immunity of Natural Killer Cells via Elevating Extracellular ATP.docx by Hui Cong (3909211)

“…Such UQCRC1-induced impairment of NK cells was mediated by eATP and its metabolite adenosine via P2Y11R and A_2AR, respectively. Mechanistically, we found the UQCRC1/eATP axis reduced the expression of chemokine CCL5 in cancer cells and altered the balance of activating receptor DNAM-1 and inhibitory receptor CD96 on NK-92MI cells, resulting in decreased chemotaxis and exhausted phenotype of NK-92MI cells. …”

Table_1_Mendelian randomization in blood metabolites identifies triglycerides and fatty acids saturation level as associated traits linked to pancreatitis risk.xlsx by Jiarui Mi (11170284)

“…Next, we exploited the MR-BMA method to pinpoint the dominating factors on the increased risk of pancreatitis.…”

Data_Sheet_1_Involvement of Gut Microbiota in the Development of Psoriasis Vulgaris.doc by Chaonan Sun (4681345)

“…Accumulating observations show gut microbiota dysbiosis in psoriasis. We intend to further investigate the relationship between intestinal microbiota and psoriasis development.…”

Type 2 Diabetes Risk Alleles Demonstrate Extreme Directional Differentiation among Human Populations, Compared to Other Diseases by Rong Chen (29176)

“…To examine these patterns, we manually curated ethnic disease association data from 5,065 papers on human genetic studies representing 1,495 diseases, recording the precise risk alleles and their measured population frequencies and estimated effect sizes. …”

DataSheet1_Unraveling Structural Phase Transformation by Simultaneously Determining the Lattice Constants and Mismatch Angle in VO2/Al2O3 Epitaxial Thin Films.docx by Yichao Liu (3982652)

“…The lattice constants a, b, and c were approximately 5.723, 4.521, and 5.393 Å, respectively, at room temperature, and the mismatch angle was approximately 122.02°. …”

Low Vitamin D Status Is Associated with Nonalcoholic Fatty Liver Disease Independent of Visceral Obesity in Korean Adults by Ji A. Seo (468582)

“…When we classified non-diabetic subjects by HOMA-IR, an increase in the OR for NAFLD across decreasing quartiles of 25(OH)D was observed in the high HOMA-IR (≥2.5) group [n = 207, Q1 vs. …”