Increased synaptosomal Nox-2 activation and superoxide production in old wild-type mice is absent in old IL-6-/- mice; determination by electrochemical oxygen consumption analysis... by Laura L. Dugan (264427)

“…Oxygen consumption by synaptosomal Nox from the cortex of young (3–4 M, n = 9) and old (23–24 M, n = 9) animals at 37°C was induced by the addition of 5 mM NADPH to samples containing 2–5 mg synaptosomal protein. …”

Table 1_NOTCH1 and UPR signaling in embryonic heart development under maternal high-fat diet influence.doc by Yupeng Shi (1932442)

“…Maternal blood was collected at P5.5, P10.5, and P14.5 to assess lipid levels. Embryonic hearts at E14.5 were examined by H&E staining, and ventricular protein expression of NOTCH1 and UPR-related molecules was measured via Western blot. …”

datasheet1_Inhibition of Lipid Accumulation in Skeletal Muscle and Liver Cells: A Protective Mechanism of Bilirubin Against Diabetes Mellitus Type 2.pdf by Claudia A. Hana (10028828)

“…In conclusion, our findings show that UCB considerably decreases lipid accumulation in skeletal muscle and liver cells within a short incubation time of max. 5 h which suggests that mildly elevated bilirubin levels could lower ectopic lipid deposition, a major key element in the pathogenesis of DMT2.…”

Cosmosiin and angolensin inhibit PC3 cell motility and migration. by Emily Powell (185352)

“…(B) Transwell migration assays measured the ability of cosmosiin (B) and angolensin (C) to inhibit cellular migration of PC3 cells toward a chemoattractant. Cosmosiin (B) and angolensin (C) decreased the ability of PC3 cells to migrate through the pore, and this decreased ability was ablated by the antagonist ICI 182,780 at 100 nM.…”

Figure 7 by Jonathan H. Fox (273480)

“…<p>Amyloid precursor protein (APP), a copper exporting protein, is decreased at the protein but not transcript level in the brains of 12-week-old HD transgenic mice. …”

EGF induces C/EBPβ expression in SAS cells. by Wen-Cheng Lu (630775)

“…(C) Activation of AKT by plasmid transfection for 24 h (Upper) and treatment with LY294002 for 24 h (Lower) increased and decreased C/EBPß expression, respectively. (D) Transfection with 100 nM si-C/EBPβ oligonucleotide down-regulated <i>C/EBPβ</i> mRNA expression at 48 h and 72 h (Upper); it also down-regulated C/EBPβ protein expression at 48 h (Lower). …”

Effect of ORS on β-catenin expression. by Da-yong Zhang (5650246)

“…After treatment with 100 ng/mL DKK1, the nuclear β-catenin expression decreased. …”

Immunohistochemistry of Adult OC2 Knockout Retinas. by Jillian J. Goetz (644028)

“…<p>Changes in mature retinal cell populations resulting from the loss of OC2 were examined using immunohistochemistry. Rod photoreceptors (A,A'), amacrine cells (B,B',C,C'), bipolar cells (D,D'), and Muller glia (E,E') were unchanged, whereas the horizontal cell population was greatly decreased (F,F'; arrowheads indicate horizontal cell bodies). …”

Dynamic changes in peripheral and myeloid chimerism. by Yaojun Wang (309584)

“…At POD 42, chimerism in group 5 returned to a total level 8.7%±0.6% but it decreased to background level in group 6 (<i>P</i><0.05). …”

Simulation results for 1D cells in track model. by Cameron W. Harvey (106938)

“…<p>A) Plot shows the effect of decreasing the passing probability from 1.0 to 0.1 by looking at the fraction of empty positions in the track. …”

Functional characterization of human myosin-binding protein C3 variants associated with hypertrophic cardiomyopathy reveals exon-specific cardiac phenotypes in zebrafish model by Da'as, Sahar I.

“…MYBPC3 variants genotype–phenotype associations remain poorly understood. We investigated the impact of two novel human MYBPC3 splice-site variants: V1: c.654+2_654+4dupTGG targeting exon 5 using morpholino MOe5i5; and V2: c.772+1G'A targeting exon 6 using MOe6i6; located within C1 domain of cMyBP-C protein, known to be critical in regulating sarcomere structure and contractility. …”
Get full text
Get full text
Get full text

Safety and efficacy of ferric citrate in patients with nondialysis-dependent chronic kidney disease by Glenn M. Chertow (2967792)

“…Treatment-emergent adverse events (AEs) were reported in 143 of 190 (75.3%) FC-treated and 116 of 188 (61.7%) placebo-treated patients; gastrointestinal AEs were the most frequent (94 [49.5%] vs. 52 [27.7%], respectively). Specific events reported in >5% of patients (FC vs. placebo, respectively) included discolored feces (41 [21.6%] vs. 0 [0.0%]), diarrhea (39 [20.5%] vs. 23 [12.2%]), constipation (35 [18.4%] vs. 19 [10.1%]), and nausea (18 [9.5%] vs. 8 [4.3%]). …”

Th1 Response and Systemic Treg Deficiency in Inclusion Body Myositis by Yves Allenbach (483114)

“…This was associated with an increased frequency of CD8⁺CD28⁻ T cells (45.6±18.5% vs. 13.5±9.9%; p<0.0001), which were more prone to produce IFN-γ (45.6±18.5% vs. 13.5±9.9%; p<0.0001). sIBM patients also had a decreased frequency of circulating regulatory T cells (CD4⁺CD25⁺CD127^lowFOXP3⁺, 6.9±1.7%; vs. 5.2±1.1%, p = 0.01), which displayed normal suppressor function and were also present in affected muscle.…”

Identification of candidate genes associated with photosynthesis in eggplant under elevated CO₂ by Xiaoyong Xu (276757)

“…The results showed that elevated CO₂ can promote eggplant growth and development in greenhouses; plant height and stem diameter were maximally increased by 28.62% and 5.20%, respectively. Net photosynthetic rate, light saturation point and intercellular CO₂ concentration of eggplant leaves increased by 86.11%, 49.94% and 102.06%, respectively, whereas light compensation point, dark breathing rate and stomatal conductance decreased by 35.90%, 27.30% and 26.03%, respectively. …”

Table 1_Characterization of the airway microbiome in preterm infants with bronchopulmonary dysplasia.doc by Zhidan Bao (22418314)

“…However, BPD infants required prolonged duration for Continuous Positive Airway Pressure (25.0 d vs 8.5 d, P = 0.001), oxygen therapy (38.0 d vs 20.5 d, P = 0.001), antibiotic treatment (9.5 d vs 4.5 d, P = 0.004), and prolonged hospital admissions (44.0 d vs 25.5 d, P = 0.002). …”

Urology Residents' Perspectives on the In-House On-Call Systems: A Study in an Accredited Academic Center by Khalil, Ibrahim A. and Ibrahim, Tarek and Aldeeb, Maya and Mohamed, Ahmed and Ben Salah, Rym and Aboumarzouk, Omar M. and Al-Naimi, Abdulla

“…Quality of life and education: We adopted a validated survey based on a 5-point Likert scale to assess the residents' perception of the transition to a 12-hour on-call system on their quality of life and education. …”
Get full text
Get full text

Intense light-elicited up-regulation of miR-21 facilitates glycolysis and cardioprotection in a Per2-dependent mechanism by Tobias Eckle (3609815)

“…To profile Per2 mediated pathways following IP of the mouse heart, we performed a genome array and identified 352 abundantly expressed and well-characterized Per2 dependent micro RNAs<a>. …”

Indirect Effects of COVID-19 on Maternal, Neonatal, Child, Sexual and Reproductive Health Services in Kampala, Uganda by Kirsty Le Doare (10716090)

“…We found a rise in adverse pregnancy outcomes for Caesarean sections (5%), haemorrhages related to pregnancy (51%), stillbirths (31%) and low-birth-weight (162%) and premature infant births (400%). …”

Autophagy and Apoptosis Are Differentially Induced in Neurons and Astrocytes Treated with an <em>In Vitro</em> Mimic of the Ischemic Penumbra by Matthew E. Pamenter (111599)

“…We found that IS-treated cells exhibited a phenotype of mixed apoptosis/autophagy characteristic of the <em>in vivo</em> penumbra, including: (1) short-term elevation of [ATP] followed by progressive ATP depletion and Poly ADP Ribose Polymerase cleavage, (2) increased vacuole number in the cytoplasm, (3) mitochondrial rupture, decreased mitochondrial and cristae density, release of cytochrome C and apoptosis inducing factor, (4) chromatin condensation, nuclear lamin A and DNA cleavage, fragmentation of the nuclear envelope, and (5) altered expression of mRNA and proteins consistent with autophagy and apoptosis. …”

A Cohort Study of Serum Bilirubin Levels and Incident Non-Alcoholic Fatty Liver Disease in Middle Aged Korean Workers by Yoosoo Chang (164509)

“…</p> <h3>Methods and Findings</h3><p>We performed a cohort study in 5,900 Korean men, 30 to 59 years of age, with no evidence of liver disease and no major risk factors for liver disease at baseline. …”