image4_Safety and Efficacy of Bromodomain and Extra-Terminal Inhibitors for the Treatment of Hematological Malignancies and Solid Tumors: A Systematic Study of Clinical Trials.jpeg by Yanli Sun (1559716)

“…According to published data, the rates of SD, PD, CR and PR were 27.4%, 37.6%, 3.5%, and 5.7%, respectively, which is not very satisfactory. …”

Image_6_GPCR19 Regulates P2X7R-Mediated NLRP3 Inflammasomal Activation of Microglia by Amyloid β in a Mouse Model of Alzheimer’s Disease.tif by Jahirul Islam (11280516)

“…Furthermore, TDCA enhanced phagocytosis of Aβ and decreased the number of Aβ plaques in the brains of 5x Familial Alzheimer’s disease (5xFAD) mice. …”

A New Functional MRI Approach for Investigating Modulations of Brain Oxygen Metabolism by Valerie E. M. Griffeth (278482)

“…If more specific information regarding changes in CMRO₂ is required, then with accuracy similar to that of the Davis model, the heuristic model can be applied to calibrated BOLD data at 1.5T, 3T and 7T. Both models work well over a reasonable range of blood flow and oxygen metabolism changes but are less accurate when applied to a simulated caffeine experiment in which CBF decreases and CMRO₂ increases.…”

Data_Sheet_1_Exosomes Derived From Macrophages Enhance Aerobic Glycolysis and Chemoresistance in Lung Cancer by Stabilizing c-Myc via the Inhibition of NEDD4L.DOCX by Huan Wang (109286)

“…MDE exhibited high expression level of several miRNA including miR-3679-5p. Mechanistically, miR-3679-5p was delivered to lung cancer cells by MDE, downregulating the expression of a known E3 ligase, NEDD4L, which has been identified as a key regulator controlling the stability of c-Myc. …”

Data_Sheet_1_Identification and Computational Analysis of Novel TYR and SLC45A2 Gene Mutations in Pakistani Families With Identical Non-syndromic Oculocutaneous Albinism.docx by Nousheen Bibi (446289)

“…Sequence analysis identified a novel insertion variant (NM_016180.5: c.1331_1332insA) in the SLC45A2. Further, in silico mutagenesis and dynamic simulation approaches revealed that a novel Cys276Arg variant abolished the cysteine bridge and might contribute toward decreased stability of the TYR protein. …”

Systemic effects of angiogenesis inhibition alter pharmacokinetics and intratumoral delivery of <i>nab</i>-paclitaxel by Anne Steins (839229)

“…In this study, patient-derived xenograft mouse models of esophageal adenocarcinoma were used to identify the effects of DC101, a murine vascular endothelial growth factor receptor 2 (VEGFR2) inhibitor, on the pharmacokinetics and the intratumoral uptake of <i>nab</i>-paclitaxel (NPTX). We showed that DC101 had large systemic effects resulting in decreased vasculature of intraperitoneally located organs. …”

Image 1_Temporary trigeminal ganglion stimulation can improve zoster-related trigeminal neuralgia: a retrospective study in a single center.tif by Kan Yue (1378518)

“…At the six-month follow-up, the mean VAS score decreased from preoperative 6.1 ± 1.5 to 2.5 ± 1.9, demonstrating a statistically significant reduction (t = 4.36, p < 0.05). …”

DataSheet_1_Emodin Inhibits Inflammation, Carcinogenesis, and Cancer Progression in the AOM/DSS Model of Colitis-Associated Intestinal Tumorigenesis.pdf by Yunsha Zhang (9961550)

“…Emodin, is a natural anthraquinone derivative with anti-oxidant, anti-inflammatory, and anti-tumor activities. We used the AOM/DSS model of colitis-associated intestinal tumorigenesis to characterize the effect of Emodin on inflammation and tumorigenesis at weeks 3, 5, and 14 after initiation with AOM. …”

image6_Safety and Efficacy of Bromodomain and Extra-Terminal Inhibitors for the Treatment of Hematological Malignancies and Solid Tumors: A Systematic Study of Clinical Trials.jpeg by Yanli Sun (1559716)

“…According to published data, the rates of SD, PD, CR and PR were 27.4%, 37.6%, 3.5%, and 5.7%, respectively, which is not very satisfactory. …”

Image_10_GPCR19 Regulates P2X7R-Mediated NLRP3 Inflammasomal Activation of Microglia by Amyloid β in a Mouse Model of Alzheimer’s Disease.tif by Jahirul Islam (11280516)

“…Furthermore, TDCA enhanced phagocytosis of Aβ and decreased the number of Aβ plaques in the brains of 5x Familial Alzheimer’s disease (5xFAD) mice. …”

Table_4_Global Transcriptomic Analysis of the Canine corpus luteum (CL) During the First Half of Diestrus and Changes Induced by in vivo Inhibition of Prostaglandin Synthase 2 (PTG... by Miguel Tavares Pereira (7857989)

“…Little effect was observed on days 5 and 10. Day 20 had the highest number of DEGs (n = 1,741), related with increased immune response. …”

Hypospadias Reconstruction Training: Development of an Ex-Vivo Model for Objective Evaluation of Surgical Skills by Abbas, Tariq

“…ResultsThe course included 18 participants (10 female, 8 males; average age 40.18 ± 8.46 years) categorized as novice (n = 10, <3 years’ experience), intermediate (n = 5, 3-5 years), and expert (n = 3, >5 years). Video evaluations did not reveal significant differences due to short-term training. …”
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Sensitivity analysis of the results of Fig 3, for the high school contact network, w.r.t. graph of persistent contacts. by Simon Mauras (11337066)

“…Part (b) is a construction of what we call a <i>best friends</i> graph, constructed in the following two steps: First, each person lists their neighbor by order of decreasing number of contacts, stopping as soon as they reach 25% or their total number of contacts. …”

Characterization of <i>Acinetobacter</i> type IVa pilus components. by Ruben Iruegas (6203684)

“…Taxa are ordered according to increasing phylogenetic distance to <i>A</i>. <i>baumannii</i> using the information provided in [<a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1010646#pgen.1010646.ref021" target="_blank">21</a>] and [<a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1010646#pgen.1010646.ref100" target="_blank">100</a>]. …”

Supplementary file 1_Effects of nitrogen addition on SOC in alpine grasslands of the Qinghai-Tibetan Plateau and adjacent mountain regions: a meta-analysis.docx by Yanhui Ye (22775894)

“…Conversely, soil respiration decreased by 5.1%, whereas the microbial respiration rate increased by 21.9%. …”

Data_Sheet_1_Serotype distribution, clinical characteristics, and antimicrobial resistance of pediatric invasive pneumococcal disease in Colombia during PCV10 mass vaccination (201... by Germán Camacho-Moreno (13847773)

“…</p>Results<p>We report 530 patients, 215 (40.5%) were younger than 24 months. …”

Data_Sheet_2_Serotype distribution, clinical characteristics, and antimicrobial resistance of pediatric invasive pneumococcal disease in Colombia during PCV10 mass vaccination (201... by Germán Camacho-Moreno (13847773)

“…</p>Results<p>We report 530 patients, 215 (40.5%) were younger than 24 months. …”

Image_1_Serotype distribution, clinical characteristics, and antimicrobial resistance of pediatric invasive pneumococcal disease in Colombia during PCV10 mass vaccination (2017–202... by Germán Camacho-Moreno (13847773)

“…</p>Results<p>We report 530 patients, 215 (40.5%) were younger than 24 months. …”

Supplementary Material for: Intrauterine growth restriction disrupts the postnatal critical period of synaptic plasticity in the mouse dorsal hippocampus in a model of hypertensive... by St.Pierre M. (11862722)

“…ImageJ/Fiji and IMARIS were used for image processing and SPSS v24 for statistical analysis. Results: Although PV+ interneuron (IN) numbers and IR intensity were unchanged, development of GAD65/67+ synaptic boutons was accelerated at P18 IUGR mice, and inversely correlated with decreased expression of PSA-NCAM in the CA of P18 IUGR mice at P18. …”

Cortical UP DOWN state synchrony drives propofol phase amplitude coupling in slow waves by Austin Soplata (12089999)

“…In contrast, applying indirect propofol effects via decreasing acetylcholine (ACh) cortical tone enabled cortical SWO generation by decreasing pyramidal K(Na)-current conductance. …”