A Spontaneous Mutation of the Rat <em>Themis</em> Gene Leads to Impaired Function of Regulatory T Cells Linked to Inflammatory Bowel Disease by Marianne Chabod (187222)

“…In BN^m rats, we found that the T cell lymphopenia originated in the thymus, was intrinsic to CD4 T lymphocytes, and was associated with the development of an inflammatory bowel disease. …”

Table_1_Overexpression of Cinnamoyl-CoA Reductase 2 in Brassica napus Increases Resistance to Sclerotinia sclerotiorum by Affecting Lignin Biosynthesis.DOCX by Dongxiao Liu (583846)

“…We further evaluated the Sclerotinia resistance of BnaC.CCR2.b overexpression lines at the flower-termination stage and found that the disease lesions on the stems of plants in the T₂ and T₃ generations decreased by 12.2–33.7% and 32.5–37.3% compared to non-transgenic control plants, respectively, at 7days post-inoculation (dpi). …”

Table_2_Longitudinal High-Throughput Sequencing of the T-Cell Receptor Repertoire Reveals Dynamic Change and Prognostic Significance of Peripheral Blood TCR Diversity in Metastatic... by Yi-Tung Chen (6743102)

“…We found that TCRα repertoires, TCRβ repertoires, and CDR3 clonotypes were altered in mCRC patients compared with healthy controls. …”

Table3_Dynamic Epicardial Contribution to Cardiac Interstitial c-Kit and Sca1 Cellular Fractions.docx by C. Pogontke (12677213)

“…</p><p>Results: Our data show that approximately 50% of cardiac c-Kit^POS cells are derived from the Wt1-lineage at E15.5. This subpopulation decreased along with embryonic development, disappearing from P7 onwards. …”

Data_Sheet_1_G721-0282 Exerts Anxiolytic-Like Effects on Chronic Unpredictable Mild Stress in Mice Through Inhibition of Chitinase-3-Like 1-Mediated Neuroinflammation.DOCX by Hyeon Joo Ham (7623410)

“…Chitinase-3-like 1 (CHI3L1) is expressed in several chronic inflammatorily damaged tissues and is well known to play a major role in mediating inflammatory responses. In the present study, we investigated the anxiolytic-like effect of N-Allyl-2-[(6-butyl-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidin-5-yl)sulfanyl]acetamide (G721-0282), an inhibitor of CHI3L1, on mice treated with chronic unpredictable mild stress (CUMS), as well as the mechanism of its action. …”

Demographic Effects of Habitat Restoration for the Grey-Crowned Babbler <i>Pomatostomus temporalis</i>, in Victoria, Australia by Peter A. Vesk (770301)

“…Restoration was responsible for a difference of about one bird per group of 3-5 individuals; this is an important effect on the reproductive success of the social group. …”

Data Sheet 1_The relationship between inflammatory factors and heart failure: evidence based on bidirectional Mendelian randomization analysis.zip by Xuanchun Huang (17359851)

“…Reverse Mendelian randomization suggested that the onset of heart failure might potentially influence the levels of four inflammatory factors, with ARTN and FGF5 decreasing after the onset of heart failure, and SLAM and MMP-10 increasing. …”

Xrn1 influence on gene transcription results from the combination of general effects on elongating RNA pol II and gene-specific chromatin configuration by Victoria Begley (4670281)

“…RNA pol II profiles at 5ʹ exhibited significant alterations that were compatible with decreased elongation rates in the absence of Xrn1. …”

Image1_Comprehensive in vitro and in silico assessments of metabolic capabilities of 24 genomic variants of CYP2C19 using two different substrates.TIF by Myung-Eui Seo (6822518)

“…We also identified polymorphic proteins indicating different tendencies of metabolic capability between the two substrates (5/24).…”

Data_Sheet_2_Analysis of gut microbiome composition, function, and phenotype in patients with osteoarthritis.docx by Su Liu (1965895)

“…Prevotella could distinguish between OA patients and healthy people with a better diagnostic power (AUC = 77.5%, p < 0.001, 95% CI: 66.9–88.1%). The functions of DNA transcription, amino acid metabolism (including histidine, lysine, and isoleucine), ATP metabolism, and phospholipid metabolism significantly decreased, while glucose metabolism, protein acetylation, and aspartate kinase activity significantly increased in the OA group. …”

Gene expression and metabolite profiling of gibberellin biosynthesis during induction of somatic embryogenesis in <i>Medicago truncatula</i> Gaertn by Rafał Igielski (4281487)

“…Moreover, by analyzing expression of <i>MtBBM</i>, SE marker gene, we confirmed the inhibitory effect of manipulation in GA_s metabolism, applying exogenous GA₃, which not only impaired the production of somatic embryos, but also significantly decreased expression of this gene.…”

Data_Sheet_3_Analysis of gut microbiome composition, function, and phenotype in patients with osteoarthritis.docx by Su Liu (1965895)

“…Prevotella could distinguish between OA patients and healthy people with a better diagnostic power (AUC = 77.5%, p < 0.001, 95% CI: 66.9–88.1%). The functions of DNA transcription, amino acid metabolism (including histidine, lysine, and isoleucine), ATP metabolism, and phospholipid metabolism significantly decreased, while glucose metabolism, protein acetylation, and aspartate kinase activity significantly increased in the OA group. …”

Intragenic <i>ERG</i> Deletions Do Not Explain the Biology of <i>ERG</i>-Related Acute Lymphoblastic Leukemia by Eliska Potuckova (525220)

“…They represent the only genetic lesion described so far present in the majority of cases clustering into a subgroup of B-other subtype characterized by a unique gene expression profile, probably sharing a common, however, not yet fully described, biological background. We aimed to elucidate whether <i>ERG</i> deletions could drive the specific biology of this <i>ERG</i>-related leukemia subgroup through expression of aberrant or decreased expression of wild type <i>ERG</i> isoforms. …”

Image1_Dynamic Epicardial Contribution to Cardiac Interstitial c-Kit and Sca1 Cellular Fractions.TIF by C. Pogontke (12677213)

“…</p><p>Results: Our data show that approximately 50% of cardiac c-Kit^POS cells are derived from the Wt1-lineage at E15.5. This subpopulation decreased along with embryonic development, disappearing from P7 onwards. …”

Table_3_Seasonal Hypometabolism in Female Moose.DOCX by Anne Randi Græsli (8800793)

“…We documented seasonal differences in T_b, HR and activity of moose, with lower levels during winter and higher values during summer. …”

Image_2_Aberrant Expression of Cardiac Troponin-T in Lung Cancer Tissues in Association With Pathological Severity.TIF by Toshihiro Tsuruda (90244)

“…In addition, frequency of positive staining for TNNT2 increased with pleural (χ² = 5.877, P = 0.015) and vascular (χ² = 2.449, P = 0.118) invasions but decreased with lymphatic invasion (χ² = 3.288, P = 0.070) in specimens performed surgical resection. …”

Image_1_Palmitoylethanolamide Ameliorates Carbon Tetrachloride-Induced Liver Fibrosis in Rats.PDF by Masatsugu Ohara (5511236)

“…Liver fibrosis was induced by an intraperitoneal injection of 1.5 mL/kg of 50% carbon tetrachloride twice a week for 4 weeks. …”

Additive Effects of Millimeter Waves and 2-Deoxyglucose Co-Exposure on the Human Keratinocyte Transcriptome by Yonis Soubere Mahamoud (2967282)

“…We found that the 2dG treatment decreased the cellular ATP content and induced a high modification in the transcriptome (632 coding genes). …”

Data_Sheet_1_Analysis of gut microbiome composition, function, and phenotype in patients with osteoarthritis.xlsx by Su Liu (1965895)

“…Prevotella could distinguish between OA patients and healthy people with a better diagnostic power (AUC = 77.5%, p < 0.001, 95% CI: 66.9–88.1%). The functions of DNA transcription, amino acid metabolism (including histidine, lysine, and isoleucine), ATP metabolism, and phospholipid metabolism significantly decreased, while glucose metabolism, protein acetylation, and aspartate kinase activity significantly increased in the OA group. …”

Association between breastfeeding and eczema during childhood and adolescence: A cohort study by Jingying Wang (4458820)

“…</p><p>Methods</p><p>In the prospective, population-based Leicester Respiratory Cohort study, we assessed duration of breastfeeding in children aged 1–4 years. …”