The GABBR1/miR-19b-3p/WNT2B axis regulates insulin resistance and liver injury in diabetes with viral infection: mechanistic and therapeutic insights by Rui Yang (293531)

DataSheet1_Macleayins A From Macleaya Promotes Cell Apoptosis Through Wnt/β-Catenin Signaling Pathway and Inhibits Proliferation, Migration, and Invasion in Cervical Cancer HeLa Ce... by Chunmei Sai (11240097)

“…The Wnt/β-catenin signaling cascade activation was verified using the Dual-Glo® Luciferase assay. We found that MA inhibited the growth of HeLa cells at 72 h (IC₅₀ = 26.88 µM) via inducing apoptotic process, reduced the proliferation rate by 29.89%, and decreased the cells migration and invasion as compared to the untreated group. …”

Table 2_Interactions between the intestinal microbiome and host genes in regulating vibriosis resistance in Cynoglossus semilaevis.xlsx by Weiwei Zheng (140828)

“…</p>Methods<p>In this study, we investigated the changes in intestinal histopathology, intestinal microbiome and host gene expression in resistant and susceptible individuals at 7 days post infection with Vibrio harveyi, and identified the host gene-microbe correlations. …”

Data_Sheet_1_Effectiveness of Transcranial Direct Current Stimulation and Monoclonal Antibodies Acting on the CGRP as a Combined Treatment for Migraine (TACTIC): Protocol for a Ran... by Raffaele Ornello (5213582)

“…Conversely, neuromodulation techniques such as transcranial direct current stimulation (tDCS) act centrally by increasing or decreasing the neuronal firing rate of brain cortical areas. …”

Supplementary Material for: Stent Thrombosis with Biodegradable Polymer Drug-Eluting Stents versus Durable Polymer Sirolimus-Eluting Stents: An Update Meta-Analysis by Zhu L. (2945931)

Image_2_Complex metabolic interactions between ovary, plasma, urine, and hair in ovarian cancer.tif by Xiaocui Zhong (8785130)

“…<p>Ovarian cancer (OC) is the third most common malignant tumor of women accompanied by alteration of systemic metabolism, yet the underlying interactions between the local OC tissue and other system biofluids remain unclear. In this study, we recruited 17 OC patients, 16 benign ovarian tumor (BOT) patients, and 14 control patients to collect biological samples including ovary plasma, urine, and hair from the same patient. …”

DataSheet_1_Yizhi Qingxin Formula Extract Ameliorates Cognitive Decline in Aged Rats via the Brain-Derived Neurotrophic Factor/Tropomyosin Receptor Kinase B Pathway.pdf by Lina Ma (199509)

“…Fifty male Wistar rats were randomly divided into five groups: Control group, Model group, Donepezil group, and YQF extract groups (treatment with YQF extract at two different doses). …”

Altered Immune Responses in Rhesus Macaques Co-Infected with SIV and <em>Plasmodium cynomolgi</em>: An Animal Model for Coincident AIDS and Relapsing Malaria by Jeffrey W. Koehler (259360)

“…</p><h3>Methodology/Principal Findings</h3><p>Five rhesus macaques were infected with <em>P. cynomolgi</em> and, following three parasite relapses, with SIV. …”

Renal Tubule-Specific Angiotensinogen Deletion Attenuates SGLT2 Expression and Ameliorates Diabetic Kidney Disease in Murine Models of Type 1 Diabetes by Wen-Xia Yang (20485041)

Image_2_Beta Diversity Patterns of Post-fire Forests in Central Yunnan Plateau, Southwest China: Disturbances Intensify the Priority Effect in the Community Assembly.JPEG by Jie Han (128758)

“…The central Yunnan Plateau of Southwest China is characterized by monsoon related seasonal drought, and frequent forest fires. We sampled five fire sites burned in different years and a middle aged forest, measured species composition dissimilarity and its species turnover and nestedness components, within each fire site and across all sites. …”

Table_4_Spectral Composition of Light Affects Sensitivity to UV-B and Photoinhibition in Cucumber.DOCX by Carolina Falcato Fialho Palma (9938513)

“…Our results showed that supplementary UV-B significantly decreased biomass accumulation in the presence of broad band white, blue and green light, but not under red light. …”

Table 2_Antifungal mechanism and transcriptome analysis of Bacillomycin D-C16 against Fusarium oxysporum.docx by Fuxing Lin (7418234)

“…Biochemical assays confirmed these observations: Reduced activities of mitochondrial enzymes [malate dehydrogenase (MDH), isocitrate dehydrogenase (IDH), pyruvate dehydrogenase (PDH), and complexes I–V], decreased mitochondrial membrane potential, and diminished ATP content collectively indicated mitochondrial dysfunction. …”

Endothelial overexpression of metallothionein prevents diabetes mellitus-induced impairment in ischemia angiogenesis via preservation of HIF-1α/SDF-1/VEGF signaling in endothelial... by Ada Admin (8524211)

DNA hypomethylation-mediated activation of <i>Cancer/Testis Antigen 45</i> (<i>CT45</i>) genes is associated with disease progression and reduced survival in epithelial ovarian can... by Wa Zhang (758326)

Table_1_Multiple Myeloma-Derived Extracellular Vesicles Impair Normal Hematopoiesis by Acting on Hematopoietic Stem and Progenitor Cells.DOCX by Ilaria Laurenzana (1528111)

“…Our data showed that: (i) MM cells released a heterogeneous population of EVs; (ii) MM-EVs caused a dose-dependent reduction of HSPCs viability; (iii) MM-EVs caused a redistribution of the HSPC pool characterized by a significant increase in the frequency of stem and early precursors accompanied by a reduction of late precursor cells, such as common myeloid progenitors (CMPs), megakaryocyte erythroid progenitors (MEPs), B and NK progenitors, and a slight increase of granulocyte macrophage progenitors (GMPs); (iv) MM-EVs caused an increase of stem and early precursors in S phase with a decreased number of cells in G₀/G₁ phase in a dose-dependent manner; (v) MM-EVs reduced the HSPC colony formation; and (vi) MM-EVs caused an increased expression level of C-X-C motif chemokine receptor type 4 (CXCR4) and activation of miRNAs. …”

DataSheet1_Development and validation of a pyroptosis-related genes signature for risk stratification in gliomas.docx by Penggang Sun (14605193)

“…Furthermore, knockdown of GSDMD decreased the expression of IL-1β and cleaved caspase-1.…”

Image_2_Mixed Hypertrophic and Dilated Phenotype of Cardiomyopathy in a Patient With Homozygous In-Frame Deletion in the MyBPC3 Gene Treated as Myocarditis for a Long Time.tiff by Olga Blagova (9418328)

Table_7_Spectral Composition of Light Affects Sensitivity to UV-B and Photoinhibition in Cucumber.DOCX by Carolina Falcato Fialho Palma (9938513)

“…Our results showed that supplementary UV-B significantly decreased biomass accumulation in the presence of broad band white, blue and green light, but not under red light. …”

Table 1_Interactions between the intestinal microbiome and host genes in regulating vibriosis resistance in Cynoglossus semilaevis.xlsx by Weiwei Zheng (140828)

“…</p>Methods<p>In this study, we investigated the changes in intestinal histopathology, intestinal microbiome and host gene expression in resistant and susceptible individuals at 7 days post infection with Vibrio harveyi, and identified the host gene-microbe correlations. …”

Image 3_Selective inhibition of canonical STAT3 signaling suppresses K-ras mutant lung tumorigenesis and reinvigorates anti-tumor immunity.tif by Michael J. Clowers (15165896)