Datasheet1_Short hydrocarbon stapled ApoC2-mimetic peptides activate lipoprotein lipase and lower plasma triglycerides in mice.zip by Denis Sviridov (4630546)

“…We recently described a dual ApoC2 mimetic/ApoC3 antagonist peptide called D6PV that effectively lowered TG in several mouse models but has limitations in terms of drug development. …”

DataSheet2_Discovery of a New CDK4/6 and PI3K/AKT Multiple Kinase Inhibitor Aminoquinol for the Treatment of Hepatocellular Carcinoma.docx by Zhong-Kun Xia (7369511)

“…</p><p>Methods: Using a repurposing and ensemble docking methodology, we screened a library of worldwide approved drugs to identify candidate CDK4/6 inhibitors. …”

DataSheet_1_Clonally Focused Public and Private T Cells in Resected Brain Tissue From Surgeries to Treat Children With Intractable Seizures.pdf by Julia W. Chang (6271082)

“…Conversely, we found that the frequency in the blood of 18 of the top 50 brain clonotypes from a second TSC patient, who was seizure free, had significantly decreased 5 months after surgery indicating that T cell clones found in the brain had contracted in the periphery after removal of the brain area associated with seizure activity and inflammation. …”

Assessing and Responding to Palliative Care Needs in Rural Sub-Saharan Africa: Results from a Model Intervention and Situation Analysis in Malawi by Michael E. Herce (644037)

“…Mean African Palliative Outcome Scale pain score decreased non-significantly between baseline and follow-up (3.0 vs. 2.7, p = 0.5) for patients with baseline pain and complete pain assessment documentation. …”

Glutamine and Asparagine Side Chain Hyperconjugation-Induced Structurally Sensitive Vibrations by David Punihaole (1509280)

Datasheet1_Implantable cardioverter defibrillator for primary prevention in patients with non-ischemic cardiomyopathy in the era of novel therapeutic agents- meta-analysis.docx by Yotam Kolben (15787781)

“…Using previous data, we evaluated the theoretical effect of ICD implementation on patients treated with SGLT2 inhibitors and ARNi.…”

Direct Observation of Strand Passage by DNA-Topoisomerase and Its Limited Processivity by Katsunori Yogo (172528)

“…The time elapsed before the start of processive unlinking decreased with the enzyme concentration, being ∼100 s at 3.7 pM. …”

Influence of point mutations on proton sensitivity. by Katsuya Ohbuchi (559460)

“…The F587A, F591A and L670A mutations markedly decreased proton sensitivity. …”

The nonlinear behavior of the transcription noises. by Qiwen Sun (6408368)

“…(C) The noise strength Φ* varies widely from 20 to 100 with a highly nonlinear dependance on the stage durations. …”

Effect of Sonication Time on Degree of Chromatin Shearing in Fresh or Frozen Cell Suspensions. by Pamela D. Schoppee Bortz (199468)

“…Final DNA concentrations were determined via nanospectrophotometry; 2 µg of DNA per time point was used to evaluate the effect of shearing by electrophoresis in a 1% agarose gel (<b>A</b>). A small volume (7.5 µl) of unsonicated, unextracted sample (0 min) was also electrophoresed for comparison (<b>M</b>: a 100 base-pair DNA marker). …”

Immunological characterization of different ACEs. by Olga V. Kryukova (829898)

“…The ratio of precipitated activity of ACE from prostate homogenate (<b>B</b>) or epididymis homogenate (<b>C</b>) to that of lung homogenate. Data are presented as a mean of at least 3 independent experiments. Ratios increased more than by 20% are highlighted in orange and more than by 100% are highlighted in red. …”

Image_1_Combined application of melatonin and Bacillus sp. strain IPR-4 ameliorates drought stress tolerance via hormonal, antioxidant, and physiomolecular signaling in soybean.jpe... by Odongkara Peter (18861397)

“…Likewise, Bacillus–melatonin-treated plants enhanced the uptake of magnesium, calcium, and potassium by 31.2%, 50.7%, and 30.5%, respectively. Under the same conditions, the salicylic acid content increased by 29.1%, whereas a decreasing abscisic acid content (25.5%) was observed. …”

DataSheet_1_Combined application of melatonin and Bacillus sp. strain IPR-4 ameliorates drought stress tolerance via hormonal, antioxidant, and physiomolecular signaling in soybean... by Odongkara Peter (18861397)

“…Likewise, Bacillus–melatonin-treated plants enhanced the uptake of magnesium, calcium, and potassium by 31.2%, 50.7%, and 30.5%, respectively. Under the same conditions, the salicylic acid content increased by 29.1%, whereas a decreasing abscisic acid content (25.5%) was observed. …”

Lack of CHOP protein does not protect T17M <b><i>RHO</i></b><b> retinas from degeneration, as measured by scotopic ERG responses at 10DB.</b> by Sonali Nashine (408442)

“…In the 2^nd and the 3^rd months, the a-wave amplitudes declined in T17M <i>RHO</i> mice but did not decline any further in T17M <i>RHO</i> CHOP−/− mice (90.7 µv ±13.5 in T17M <i>RHO</i> vs. 82.05 µv ±8.7 in T17M <i>RHO</i> CHOP−/− at 2 months and 39.7 µv ±5.7 in T17M <i>RHO</i> vs. 44.0 µv ±8.20 in T17M <i>RHO</i> CHOP−/− at 3 months). …”

C-circles and 5' C-overhangs are linked to DNA damage-induced replication fork collapse. by Tianpeng Zhang (706243)

“…<p>(A) Replication fork stalling induced by HU or aphidicolin decreases abundance of C-circles in U2OS cells. …”

Nluc sensitivity and cellular detection limit in vitro, in vivo and ex vivo. by John D. Ventura (8087951)

“…GFP⁺ cells) were determined by flow cytometry and the 100 μl aliquot was then serially diluted two-fold on a 96 well plate and imaged using an IVIS Spectrum instrument after adding Nano-Glo Nluc substrate at a final ratio of 1:40. …”

Post-injury berberine treatment attenuated contusion volume, neuronal death and apoptosis after TBI. by Chien-Cheng Chen (207053)

“…The total number of FJB-positive cells is expressed as the mean number per field of view (0.8 mm²). Scale bar, 100 µm. (<b>H</b>) Representative terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling (TUNEL, green)- and DAPI (blue)-stained brain sections of a 10 mg·kg⁻¹ berberine- and vehicle-treated mouse at 1 day post-TBI. …”

Performance Tradeoffs Associated with Feedback Strategies by Arthur D Lander (82004)

“…</p> <p>(F) Example of a case with both activin and GDF11 feedback. Notice that now, regeneration from initial conditions of 75% ORN depletion is nearly as fast as regeneration from 100% ORN depletion (compare with [C]). …”

Risk factors for hospitalization of patients with chikungunya virus infection at sentinel hospitals in Puerto Rico by Christopher H. Hsu (6204773)

“…<div><p>Background</p><p>Hospitalization of patients during outbreaks of chikungunya virus has been reported to be uncommon (0.5–8.7%), but more frequent among infants and the elderly. …”

Data_Sheet_1_Surgery for Primary Cardiac Tumors in Children: Successful Management of Large Fibromas.docx by Tao Qian (1480588)

“…</p>Results<p>Of the 39 patients with median operative age of 9.5 [interquartile range (IQR): 1.2–16.5] years, 35 (89.7%) had benign tumors (fibromas for 15, myxomas for 13, and others for 7). …”