Mitochondria determine transcription elongation speed. by Ricardo Pires das Neves (178589)

“…Two populations of cells were sorted, with a difference in mitochondrial content of around 5-fold (R1 and R2). …”

Dataset for: The genetics of phenotypic plasticity. XVI. Interactions among traits and the flow of information by Samuel M. Scheiner (620380)

Changes of best-correct visual acuity, central retinal thickness, and subfoveal choroidal thickness among the 4 groups. by Mio Matsubara (8486133)

“…(B) Changes of central retinal thickness among the 4 groups. Mean central retinal thickness(CRT) significantly decreased from 350±100 μm at baseline to 177±33μm at 6-month, 178±31μm at 12-month, and 196±62μm at 24-month (p = 8.9×10⁻⁵, 8.9×10⁻⁵ and 2.5×10⁻⁴, respectively) in Group 0, mean CRT also significantly decreased from 475±77 μm at baseline to 205±23μm at 6-month, 197±24μm at 12-month, and 192±33μm at 24-month (p = 1.2×10⁻², 1.2×10⁻² and 1.2×10⁻², respectively) in Group 1, mean CRT significantly decreased from 400±104 μm at baseline to 207±60μm at 6-month, 221±75μm at 12-month, and 194±47μm at 24-month (p = 8.3×10⁻⁶, 3.3×10⁻⁵ and 9.3×10⁻⁶, respectively) in Group 2, and mean CRT decreased from 294±62 μm at baseline to 250±104μm at 6-month, 197±44μm at 12-month, and 238±74μm at 24-month (p = 0.25, 2.8×10⁻² and 5.8×10⁻², respectively) in Group 3. …”

Accelerated Variant of Idiopathic Pulmonary Fibrosis: Clinical Behavior and Gene Expression Pattern by Moisés Selman (29353)

“…Survival from the beginning of symptoms was significantly reduced in rapid progressors (HR = 9.0; CI:4.48-18.3; p<0.0001) and there was a tendency for decreased survival from the time of diagnosis (HR = 1.5; CI:0.81-2.87; p = 0.18). …”

Evaluation of infiltrating inflammatory cells in ear sections. by Miriam Canavese (367824)

“…<p>Haematoxylin and Eosin staining on paraffin ear sections of Balb/c females 8–12 weeks of age sensitized and challenged in a DNFB-induced CHS. 30′ after challenge, mice were treated with [⁴⁴AANA⁴⁷]-CCL5 and Met-CCL5 at 0.05–0.5–1 mg/kg ip. …”

<i>Sphagnum</i> Mosses - Masters of Efficient N-Uptake while Avoiding Intoxication by Christian Fritz (507612)

“…The interacting effects of rain N concentration and exposure time on moss N-uptake rates are, however, poorly understood.</p><p>We investigated the effects of N-concentration (1, 5, 10, 50, 100, 500 µM), N-form (¹⁵N - ammonium or nitrate) and exposure time (0.5, 2, 72 h) on uptake kinetics for <i>Sphagnum magellanicum</i> from a pristine bog in Patagonia (Argentina) and from a Dutch bog exposed to decades of N-pollution.…”

Spectroscopic and Theoretical Study of Cu^I Binding to His111 in the Human Prion Protein Fragment 106–115 by Trinidad Arcos-López (2542546)

“…Cu^I coordination to His111 is pH-dependent: at pH >8, 2N1O1S species are formed with one Met ligand; in the range of pH 5–8, both methionine (Met) residues bind to Cu^I, forming a 1N1O2S species, where N is from His111 and O is from a backbone carbonyl or a water molecule; at pH <5, only the two Met residues remain coordinated. …”

Tuning of Msn2 expression in rapidly growing cells. by Michal Chapal (7961111)

“…(F–G) Noisy Msn2 expression decreases stress protection and growth rate: we generated six strains with Msn2-YFP expressed under different promoters, which control genes with noisier expression than Msn2 but have a similar mean abundance (mean abundance in <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.3000289#pbio.3000289.s005" target="_blank">S5 Fig</a>), and deletion of <i>MSN4</i>. …”

Dynamic modeling of rapid calcium signaling in spines and dendrites. by L. Niels Cornelisse (67656)

“…Quantification of fluorescence step sizes (middle panel) and fluorescence decreases after APs (right panel) during the AP train calculated by the model cf <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0001073#pone-0001073-g002" target="_blank">Figure 2F</a>.…”

DataSheet_1_Exoantigens of Paracoccidioides spp. Promote Proliferation and Modulation of Human and Mouse Pulmonary Fibroblasts.pdf by Débora de Fátima Almeida Donanzam (9582911)

“…<p>Paracoccidioidomycosis (PCM) is a systemic granulomatous fungal infection caused by thermally dimorphic fungi of the genus Paracoccidioides. …”

Probing the auditory nerve using round-window response in control and ouabain-poisoned cochleae. by Charlène Batrel (3639406)

“…(<b>G, H</b>) Ouabain-poisoned <i>versus</i> control correlations from low- (< 5.6 kHz, <b>G</b>) and high-frequency probe (> 5.6 kHz, <b>H</b>) derived from panels A and B. …”

Correlation of Cervical Cancer Mortality with Fertility, Access to Health Care and Socioeconomic Indicators by Diama Bhadra Vale (6879314)

“…In the multivariate analysis, only fertility rate was significantly associated with the CC mortality rate (coefficient of correlation: 9.38; 95% confidence interval [CI]: 5.16-13.59). Conclusion A decrease in the fertility rate, as expected when the level of development of the regions increases, is related to a decrease in the mortality rate of CC. …”

Alteration of cellular levels of Smad2/3, pSmad2/3, Smad4, and Smad7 in NRK cells exposed to β-HB then treated with DA extract. by Shu-Fen Liu (299474)

“…B–E: Data were scanned and normalized to β-actin. β-HB treatment resulted in increased expression of Smad2/3, pSmad2/3 and Smad4, and a decrease in Smad7 expression; importantly, DA extract significantly reversed β-HB-induced increases in Smad2/3, pSmad2/3 and Smad4, and the concomitant decrease in Smad7. …”

Anti-inflammatory effects of <i>Capparis ecuadorica</i> extract in phthalic-anhydride-induced atopic dermatitis of IL-4/Luc/CNS-1 transgenic mice by Bo Ram Song (6585197)

“…PA + MCE treated Tg mice showed decreasing infiltration of mast cells (42.5%), iNOS-mediated COX‐2 induction pathway, MAPK signalling pathway and inflammasome activation in the ear tissue.…”

Supplementary Material for: Endothelial Dysfunction of the Peripheral Vascular Bed in the Acute Phase after Ischemic Stroke by Scherbakov N. (4129753)

“…A decreased RHI was observed in cardioembolic and lacunar infarcts and stroke of undetermined etiology (1.7 ± 0.4, 1.8 ± 0.5 and 1.7 ± 0.3, p < 0.0001). …”

Determinants of coronary flow reserve in non-diabetic patients with chest pain without myocardial perfusion defects by Helena U. Westergren (758365)

“…Secondly, we investigated association between cardiovascular parameters and decreased CFR in a sex specific manner.…”

Negative selection on reassortment. by Mara Villa (2855789)

“…<p>(a) The cumulative distribution of mean nucleotide distances <i>d</i> between reassortant and parent strains for the HA-NA reassortments in influenza A/H3N2 (red line) is compared to the corresponding distribution of distances for co-circulating strains in the same influenza season (solid blue line) and from the New York area only [<a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1006685#ppat.1006685.ref028" target="_blank">28</a>] (dashed blue line). …”

Variation in actuarial senescence does not reflect life span variation across mammals by Guillaume Péron (655312)

“…Combining the two steps, we computed the relative contribution of each of the five parameters to the variance in life span across species. …”

Dose-related neflamapimod (NFMD) subacute treatment effects on mNSS of rats with tMCAO. by John J. Alam (9732692)

“…In addition, a dose response effect on improvement in neurologic function was indicated by the lower mean±SD mNSS value in the 4.5 mg/kg neflamapimod dose group when compared to that of the 1.5 mg/kg dose group. …”

Data_Sheet_1_Unprecedented Retention Capabilities of Extensive Green Roofs—New Design Approaches and an Open-Source Model.PDF by Kristian Förster (6002435)

“…We consider varying flow length and slope. The novelty lies especially in the consideration of flow lengths beyond 5 m and non-declined roofs. …”