Marimastat reversed hepatic steatosis and improved surrogate markers for insulin sensitivity in diet-induced obese mice as well as in <i>ob/ob</i> animals. by Vincent E. de Meijer (343377)

“…<p>Mean hepatic fat fraction as measured by MR spectroscopy was decreased following Marimastat treatment (A). Marimastat treatment resulted in a decrease of plasma alanine aminotransferase levels (B), indicating decreased hepatic injury. …”

Corn crop evolution. by Luis García-Torres (5662132)

“…<p>A: late May and early June, corn during the vegetative growing phase, characterized by increasing NDVI values and coinciding with the T3–T4 satellite images of this stage; B: flowering stage, July, T5 image; C: senescence period, which take place in the second part of August (NDVI values decrease; satellite image T6); and D: corn stubble, beyond mid-September (satellite image T7). …”

Floral organ numbers in “Malmaison” and “St Anne's”. by Annick Dubois (19875)

“…The two rose varieties differ in two floral characters: organ identity reversions from petals in “Malmaison” to stamens in “St Anne's” and an overall decrease in total organ number. Chimeras: staminoid petals (see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0009288#pone.0009288.s002" target="_blank">Figure S1</a>). …”

Foxd1DTA mutants have cortical regions devoid of nephron progenitor caps and ureteric branching defects. by Stephanie Hum (520223)

“…<p>A–B: Six2 immunofluorescence staining showed that mutant kidneys (B) had gaps in Six2 expression in the renal cortex compared to the consistent line of nephron progenitor caps in controls (A). …”

RanGAP1 knockdown inhibited the expression of Aurora kinases and TPX2, but did not affect their transcription. by Kung-Chao Chang (170593)

“…(<b>B</b>) Q-PCR shows no significant (NS) decrease in mRNA level of Aurora-A and Aurora-B kinases in DLBCL cells, HT cells (upper panel), or SU-DHL-5 cells (lower panel). …”

Mortality by suicide in the State of Pernambuco, Brazil (1996-2015) by Barbara Marcela Beringuel (10369083)

“…The temporal trend presented a decrease of 23.5% (p=0.031). For the male sex and the age range between 20 and 39 years, there was a decline in self-inflicted death of 23.8% (p=0.018) and 26.1% (p=0.046), respectively. …”

Biochemical analysis of synaptophysin levels in transgenic mice. by Holly J. Garringer (281855)

“…No significant changes were observed at 3 months of age in synaptophysin levels between Tg-FDD-Tau and WT mice (A). A significant decrease in synaptophysin levels in Tg-FDD-Tau mice is observed at 6 months of age (B). …”

Potential mechanisms for the reducing BRCA1 expression by Christopher R Mueller (1657)

“…Methylation of both promoters through an unidentified mechanism would lead to a dramatic decrease in expression. Increased NBR2 expression could lead to decreased BRCA1 expression. p53 could inhibit factors such as E2F. …”

Relative quantities (RQ) of <i>amTOR</i> mRNA levels in honey bee larvae. by Avani Patel (30611)

“…<p>In colonies a–b, queen- (Q) and worker-destined (W) larvae are characterised by a transient two-fold difference in <i>amTOR</i> expression (present in 3^rd instar larvae, absent in spinning 5^th instar larvae). …”

The autophagy enhanced by downregulation of Chk-α contributed to protect MCF-7/TAM cells from tamoxifen. by Hoe Suk Kim (107279)

“…(B) Western blot analysis of the p62. 3-MA caused to a slight decrease in p62 level in MCF-7/TAM-shChk-α cells. …”

Immunohistochemical staining and quantification of brain sections using LFB and MBP. by Marwan Chami (4068142)

“…<p>Cuprizone treatment for 5- or 12-weeks causes a massive decrease in myelination as determined by LFB and MBP staining in the CCm <b>(a)</b>. …”

Loss of <i>Dlg-1</i> in the Mouse Lens Impairs Fibroblast Growth Factor Receptor Signaling by SungKyoung Lee (563448)

“…Herein, we asked if <i>Dlg-1</i> is a regulator of the Fibroblast growth factor receptor (Fgfr) signaling pathway, which is known to be required for fiber cell differentiation. …”

Data_Sheet_1_Soil bacteria are more sensitive than fungi in response to nitrogen and phosphorus enrichment.docx by Youchao Chen (312307)

“…However, it is still unclear on how bacterial and fungal communities would respond to the simultaneously increased N and P enrichment. In this study, we used a field experiment to simulate N and P input, and examined the effects of N and P additions on the abundance, alpha-diversity, and community composition of soil bacteria and fungi in a riparian forest. …”

Expression and prognostic impact of matrix metalloproteinase-2 (MMP-2) in astrocytomas by Rahimsan K. Ramachandran (3778768)

“…We found a positive correlation between MMP-2 and tissue inhibitor of metalloproteinases-1 (TIMP-1), and combined MMP-2 and TIMP-1 had stronger prognostic value than MMP-2 alone also when adjusting for age and gender (HR 2.78; 95% CI 1.30–5.92; p = 0.008). …”

Glycogen synthase knockdown inhibits autophagosome growth and improves CQ-induced myopathy phenotype. by Jonathan Zirin (483506)

“…(K) <i>UAS</i>–<i>GlyS</i> RNAi caused a highly significant decrease in the mean vesicle size (area) compared to the control. …”

Image_1_Ethnic and Sociocultural Differences in Ovarian Reserve: Age-Specific Anti-Müllerian Hormone Values and Antral Follicle Count for Women of the Arabian Peninsula.jpg by Laura Melado (3990398)

“…For women <45 years old, the decrease in AFC was between -0.6/-0.8 per year. Up to 36 years old, the decrease of AMH was 0.1ng/ml. …”

Image_3_Ethnic and Sociocultural Differences in Ovarian Reserve: Age-Specific Anti-Müllerian Hormone Values and Antral Follicle Count for Women of the Arabian Peninsula.jpg by Laura Melado (3990398)

“…For women <45 years old, the decrease in AFC was between -0.6/-0.8 per year. Up to 36 years old, the decrease of AMH was 0.1ng/ml. …”

Data Sheet 2_Modulation of gut microbiota by Gardeniae Fructus oil exerts TLR4/NF-κB/NLRP3 pathway-mediated antidepressant effects based on transcriptomics and fecal transplantatio... by Man Han (8444859)

“…</p>Results<p>Compared with the CON group, mice in the CUMS group showed significant depressive-like behavior, pathological damage to the hippocampus and colon tissues, significant decrease in levels of 5-HT, DA, and BDNF in the hippocampus, significant increase in levels of IL-1β, IL-6, TNF-α, DAO, and LPS in serum, significant decrease in colonic tight junction protein expression, and significant increase in protein expression of TLR4, p-NF-κB, NLRP3, ASC, and IL-1β in the hippocampus (P < 0.01); Compared with the CUMS group, the FMT group could effectively improve the above situation (P < 0.05, P < 0.01), whose therapeutic effect was second only to the OGF group (P < 0.01), while ABX + OGF group did not show obvious therapeutic effect.…”

Table_1_Ethnic and Sociocultural Differences in Ovarian Reserve: Age-Specific Anti-Müllerian Hormone Values and Antral Follicle Count for Women of the Arabian Peninsula.docx by Laura Melado (3990398)

“…For women <45 years old, the decrease in AFC was between -0.6/-0.8 per year. Up to 36 years old, the decrease of AMH was 0.1ng/ml. …”

Data Sheet 1_Modulation of gut microbiota by Gardeniae Fructus oil exerts TLR4/NF-κB/NLRP3 pathway-mediated antidepressant effects based on transcriptomics and fecal transplantatio... by Man Han (8444859)

“…</p>Results<p>Compared with the CON group, mice in the CUMS group showed significant depressive-like behavior, pathological damage to the hippocampus and colon tissues, significant decrease in levels of 5-HT, DA, and BDNF in the hippocampus, significant increase in levels of IL-1β, IL-6, TNF-α, DAO, and LPS in serum, significant decrease in colonic tight junction protein expression, and significant increase in protein expression of TLR4, p-NF-κB, NLRP3, ASC, and IL-1β in the hippocampus (P < 0.01); Compared with the CUMS group, the FMT group could effectively improve the above situation (P < 0.05, P < 0.01), whose therapeutic effect was second only to the OGF group (P < 0.01), while ABX + OGF group did not show obvious therapeutic effect.…”