Image_2_Risperidone Mitigates Enhanced Excitatory Neuronal Function and Repetitive Behavior Caused by an ASD-Associated Mutation of SIK1.TIFF by Moataz Badawi (11080101)

“…SIK1-MT protein was distributed in the nucleus and cytoplasm, whereas the distribution of wild-type SIK1 was restricted to the nucleus. We found the disruption of excitatory and inhibitory (E/I) synaptic balance due to an increase in excitatory synaptic transmission and enhancement of neural excitability in the pyramidal neurons in layer 5 of the medial prefrontal cortex in SIK1-MT mice. …”

Fibronectin Matrix Assembly Suppresses Dispersal of Glioblastoma Cells by Joshua Sabari (203453)

“…Previous studies have reported that increased cell-cell cohesion can markedly reduce invasion by discouraging cell detachment from the tumor mass. We have previously reported that α5β1 integrin-fibronectin interaction is a powerful mediator of indirect cell-cell cohesion and that the process of fibronectin matrix assembly (FNMA) is crucial to establishing strong bonds between cells in 3D tumor-like spheroids. …”

Image_2_Netrin-1 Ameliorates Postoperative Delirium-Like Behavior in Aged Mice by Suppressing Neuroinflammation and Restoring Impaired Blood-Brain Barrier Permeability.TIF by Ke Li (106849)

“…We found that a single dose of NTN-1 prophylaxis decreased the expression of IL-6 and HMGB-1 and upregulated the expression of IL-10 in the peripheral blood, hippocampus, and prefrontal cortex. …”

Autoinactivation of the Stargazin–AMPA Receptor Complex: Subunit-Dependency and Independence from Physical Dissociation by Artur Semenov (121893)

“…<div><p>Agonist responses and channel kinetics of native α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors are modulated by transmembrane accessory proteins. …”

HuR antagonizes the effect of an intronic pyrimidine-rich sequence in regulating WT1 +/−KTS isoforms by Hui Li (32376)

“…The +/−KTS isoforms were generated by alternative usage of two adjacent 5′ splice sites at RNA level, however, how these two isoforms are regulated is still elusive. …”

Image_1_Netrin-1 Ameliorates Postoperative Delirium-Like Behavior in Aged Mice by Suppressing Neuroinflammation and Restoring Impaired Blood-Brain Barrier Permeability.TIF by Ke Li (106849)

“…We found that a single dose of NTN-1 prophylaxis decreased the expression of IL-6 and HMGB-1 and upregulated the expression of IL-10 in the peripheral blood, hippocampus, and prefrontal cortex. …”

Harm Reduction Policy Support among Students at Two U.S. Universities by Barbara Andraka-Christou (8153934)

“…We analyzed data using descriptive statistics and logistic regressions. …”

Image_1_Central Treatment of Ketone Body in Rainbow Trout Alters Liver Metabolism Without Apparently Altering the Regulation of Food Intake.pdf by Sara Comesaña (5689613)

“…Using rainbow trout (Oncorhynchus mykiss) as a model, we intracerebroventricularly (ICV) administered 1 μl 100 g^–1 body mass of saline solution alone (control) or containing 0.5 μmol of BHB. …”

Experiment 2. by Lalit Pandey (13195488)

“…<p><b>(A)</b> We increased the number of hardcoded spatial operations by adding more layers to the CNN architecture. …”

Loss of the HPV-Infection Resistance EVER2 Protein Impairs NF-κB Signaling Pathways in Keratinocytes by Françoise Vuillier (5657947)

“…Finally, we demonstrate that EVER2 loss induces constitutive PKCα-dependent c-jun phosphorylation and facilitates activation of the HPV5 long control region through a JNK-dependent pathway. …”

DataSheet1_Lifestyle Behaviours of Children and Adolescents During the First Two Waves of the COVID-19 Pandemic in Switzerland and Their Relation to Well-Being: An Observational St... by Gabriela P. Peralta (8982482)

“…</p><p>Methods: In this observational study, we included 2,534 participants (5–16 years) from four Swiss cantons. …”

NOTCH1 Gain of Function in Germ Cells Causes Failure of Spermatogenesis in Male Mice by Zaohua Huang (439674)

“…Spermatogenesis in these mutants was progressively affected with age, resulting in decreased testis weight and sperm count. Analysis of downstream target genes of NOTCH1 signaling showed an increased expression of <i>Hes5</i>, with a reduction of the spermatogonial differentiation marker, <i>Neurog3</i> expression in the mutant testis. …”

Image_1_Transcriptomic and Weighted Gene Co-expression Correlation Network Analysis Reveal Resveratrol Biosynthesis Mechanisms Caused by Bud Sport in Grape Berry.TIF by Feng Leng (3769381)

“…In particular, we further identified 124 and 19 transcripts that negatively correlated with the contents of trans-resveratrol and cis-resveratrol, respectively, and four transcripts encoding F3'5'H that positively correlated with the contents of trans-resveratrol by weighted gene co-expression network analysis (WGCNA). …”

Image_1_Risperidone Mitigates Enhanced Excitatory Neuronal Function and Repetitive Behavior Caused by an ASD-Associated Mutation of SIK1.TIFF by Moataz Badawi (11080101)

“…SIK1-MT protein was distributed in the nucleus and cytoplasm, whereas the distribution of wild-type SIK1 was restricted to the nucleus. We found the disruption of excitatory and inhibitory (E/I) synaptic balance due to an increase in excitatory synaptic transmission and enhancement of neural excitability in the pyramidal neurons in layer 5 of the medial prefrontal cortex in SIK1-MT mice. …”

Image_6_Risperidone Mitigates Enhanced Excitatory Neuronal Function and Repetitive Behavior Caused by an ASD-Associated Mutation of SIK1.TIFF by Moataz Badawi (11080101)

“…SIK1-MT protein was distributed in the nucleus and cytoplasm, whereas the distribution of wild-type SIK1 was restricted to the nucleus. We found the disruption of excitatory and inhibitory (E/I) synaptic balance due to an increase in excitatory synaptic transmission and enhancement of neural excitability in the pyramidal neurons in layer 5 of the medial prefrontal cortex in SIK1-MT mice. …”

Glucose regulates microtubule disassembly and the dose of insulin secretion via tau phosphorylation by Ada Admin (8524211)

“…This remodeling involves disassembly of old microtubules and nucleation of new microtubules. Here, we examine the mechanisms whereby glucose stimulation decreases microtubule lifetimes in β-cells. …”

The 18-kDa Translocator Protein (TSPO) Disrupts Mammary Epithelial Morphogenesis and Promotes Breast Cancer Cell Migration by Xiaoting Wu (445800)

“…In breast cancer cell lines, TSPO silencing or TSPO overexpression significantly altered the migratory activity. In addition, we found that combination treatment with the TSPO ligands (PK 11195 or Ro5-4864) and lonidamine, a clinical phase II drug targeting mitochondria, decreased viability of ER-negative breast cancer cell lines. …”

Supplementary Material for: Association between Ambient Temperature and Risk of Ischaemic Stroke: An Observational Cohort Study by figshare admin karger (2628495)

“…The association was observed within 5 days before stroke onset for LAA but after a longer period for CE. …”

Spatial and temporal dynamics of shifting cultivation in the middle-Amazonas river: Expansion and intensification by Catarina Conte Jakovac (4261894)

“…We found that fallow-period length has decreased from 6.4 to 5.1 years on average, and that expansion over old-growth forest has slowed down over time. …”

Table_1_Transcriptomic and Weighted Gene Co-expression Correlation Network Analysis Reveal Resveratrol Biosynthesis Mechanisms Caused by Bud Sport in Grape Berry.DOCX by Feng Leng (3769381)

“…In particular, we further identified 124 and 19 transcripts that negatively correlated with the contents of trans-resveratrol and cis-resveratrol, respectively, and four transcripts encoding F3'5'H that positively correlated with the contents of trans-resveratrol by weighted gene co-expression network analysis (WGCNA). …”