Safety and efficacy of ferric citrate in patients with nondialysis-dependent chronic kidney disease by Glenn M. Chertow (2967792)

“…Treatment-emergent adverse events (AEs) were reported in 143 of 190 (75.3%) FC-treated and 116 of 188 (61.7%) placebo-treated patients; gastrointestinal AEs were the most frequent (94 [49.5%] vs. 52 [27.7%], respectively). Specific events reported in >5% of patients (FC vs. placebo, respectively) included discolored feces (41 [21.6%] vs. 0 [0.0%]), diarrhea (39 [20.5%] vs. 23 [12.2%]), constipation (35 [18.4%] vs. 19 [10.1%]), and nausea (18 [9.5%] vs. 8 [4.3%]). …”

Th1 Response and Systemic Treg Deficiency in Inclusion Body Myositis by Yves Allenbach (483114)

“…This was associated with an increased frequency of CD8⁺CD28⁻ T cells (45.6±18.5% vs. 13.5±9.9%; p<0.0001), which were more prone to produce IFN-γ (45.6±18.5% vs. 13.5±9.9%; p<0.0001). sIBM patients also had a decreased frequency of circulating regulatory T cells (CD4⁺CD25⁺CD127^lowFOXP3⁺, 6.9±1.7%; vs. 5.2±1.1%, p = 0.01), which displayed normal suppressor function and were also present in affected muscle.…”

Table 1_Characterization of the airway microbiome in preterm infants with bronchopulmonary dysplasia.doc by Zhidan Bao (22418314)

“…However, BPD infants required prolonged duration for Continuous Positive Airway Pressure (25.0 d vs 8.5 d, P = 0.001), oxygen therapy (38.0 d vs 20.5 d, P = 0.001), antibiotic treatment (9.5 d vs 4.5 d, P = 0.004), and prolonged hospital admissions (44.0 d vs 25.5 d, P = 0.002). …”

Metabolic Profiling and Compound-Class Identification Reveal Alterations in Serum Triglyceride Levels in Mice Immunized with Human Vaccine Adjuvant Alum by Sakda Khoomrung (1296066)

Urology Residents' Perspectives on the In-House On-Call Systems: A Study in an Accredited Academic Center by Khalil, Ibrahim A. and Ibrahim, Tarek and Aldeeb, Maya and Mohamed, Ahmed and Ben Salah, Rym and Aboumarzouk, Omar M. and Al-Naimi, Abdulla

“…Quality of life and education: We adopted a validated survey based on a 5-point Likert scale to assess the residents' perception of the transition to a 12-hour on-call system on their quality of life and education. …”
Get full text
Get full text

Intense light-elicited up-regulation of miR-21 facilitates glycolysis and cardioprotection in a Per2-dependent mechanism by Tobias Eckle (3609815)

“…To profile Per2 mediated pathways following IP of the mouse heart, we performed a genome array and identified 352 abundantly expressed and well-characterized Per2 dependent micro RNAs<a>. …”

Indirect Effects of COVID-19 on Maternal, Neonatal, Child, Sexual and Reproductive Health Services in Kampala, Uganda by Kirsty Le Doare (10716090)

“…We found a rise in adverse pregnancy outcomes for Caesarean sections (5%), haemorrhages related to pregnancy (51%), stillbirths (31%) and low-birth-weight (162%) and premature infant births (400%). …”

Autophagy and Apoptosis Are Differentially Induced in Neurons and Astrocytes Treated with an <em>In Vitro</em> Mimic of the Ischemic Penumbra by Matthew E. Pamenter (111599)

“…We found that IS-treated cells exhibited a phenotype of mixed apoptosis/autophagy characteristic of the <em>in vivo</em> penumbra, including: (1) short-term elevation of [ATP] followed by progressive ATP depletion and Poly ADP Ribose Polymerase cleavage, (2) increased vacuole number in the cytoplasm, (3) mitochondrial rupture, decreased mitochondrial and cristae density, release of cytochrome C and apoptosis inducing factor, (4) chromatin condensation, nuclear lamin A and DNA cleavage, fragmentation of the nuclear envelope, and (5) altered expression of mRNA and proteins consistent with autophagy and apoptosis. …”

A Cohort Study of Serum Bilirubin Levels and Incident Non-Alcoholic Fatty Liver Disease in Middle Aged Korean Workers by Yoosoo Chang (164509)

“…</p> <h3>Methods and Findings</h3><p>We performed a cohort study in 5,900 Korean men, 30 to 59 years of age, with no evidence of liver disease and no major risk factors for liver disease at baseline. …”

Dissolved organic matter dynamicas during 2019-2021 associated with water mass mixing in Kuroshio-Oyashio confluence region by Yunping Xu (4632430)

“…The biological index (BIX) decreases with increasing depth, indicating the in-situ production of plankton. …”

Image_1_Human B-1 Cells and B-1 Cell Antibodies Change With Advancing Age.TIF by Nely Rodriguez-Zhurbenko (6477113)

“…Our results show that not only the percentage of B-1 cells but also their ability to spontaneously secrete IgM decreased with age. Further, expression levels of the transcription factors XBP-1 and Blimp-1 were significantly lower, while PAX-5, characteristic of non-secreting B cells, was significantly higher, in healthy donors over 65 years (old) as compared to healthy donors between 20 and 45 years (young). …”

Table_3_Use of Haploid Model of Candida albicans to Uncover Mechanism of Action of a Novel Antifungal Agent.XLSX by Thuyen Truong (5351702)

“…<p>Antifungal agents for the treatment of Candida albicans infections are limited. We recently discovered a novel antifungal small molecule, SM21, with promising in vivo activity. …”

Table_1_Anticipated correlation between lean body mass to visceral fat mass ratio and insulin resistance: NHANES 2011-2018.docx by Ya Shao (16975896)

“…</p>Methods<p>In this cross-sectional study, we utilized data from the National Health and Nutrition Examination Survey (NHANES) conducted between 2011 and 2018. …”

Data_Sheet_1_Blink-related EEG oscillations are neurophysiological indicators of subconcussive head impacts in female soccer players: a preliminary study.docx by Sahar Sattari (16614447)

“…Resting state blink-related oscillations (BROs), recently discovered neurological responses following spontaneous blinking, are explored in this study to evaluate changes in BRO responses in subconcussive head impacts.</p>Methods<p>We collected 5-min resting-state electroencephalography (EEG) data from two cohorts of collegiate athletes who were engaged in contact sports (SC) or non-contact sports (HC). …”

Data_Sheet_1_CuFeS2 Nanoassemblies With Intense Near-Infrared Absorbance for Photothermal Therapy of Tumors.docx by Shan Huang (282228)

“…The CuFeS₂ nanoassemblies we developed are composed of ultrasmall CuFeS₂ nanoparticles with an average size of 5 nm, which have strong NIR photoabsorption. …”

Thyroid Hormone Regulation of Gene Expression in Primary Cerebrocortical Cells: Role of Thyroid Hormone Receptor Subtypes and Interactions with Retinoic Acid and Glucocorticoids by Pilar Gil-Ibáñez (533517)

“…<div><p>The effects of thyroid hormone on brain development and function are largely mediated by the binding of 3,5,3′-triiodo-L-thyronine (T3) to its nuclear receptors (TR) to regulate positively or negatively gene expression. …”

Table_1_Let-7g* and miR-98 Reduce Stroke-Induced Production of Proinflammatory Cytokines in Mouse Brain.DOCX by David L. Bernstein (9133364)

“…The impaired, BBB promotes the infiltration of peripheral inflammatory cells into the brain, secreting deleterious mediators (cytokines/chemokines) and resulting in permanent barrier injury. let-7 microRNAs (miRs) are critical for regulating immune responses within the BBB, particularly after ischemic stroke. We have previously shown how transient stroke decreases expression of multiple let-7 miRs, and that restoration of expression confers significant neuroprotection, reduction in brain infiltration by neutrophils, monocytes and T cells. …”

Image_2_Neural Processing of Dynamic Animated Social Interactions in Young Children With Autism Spectrum Disorder: A High-Density Electroencephalography Study.jpg by Reem K. Jan (7299143)

“…</p><p>Methods: We used a combination of 129-channel electroencephalography and high-resolution eye-tracking to study differences in the neural processing of dynamic cartoons containing human-like social interactions between 14 male children with autism spectrum disorder and 14 typically developing male children, aged 2–5 years. …”

Rapid Recovery of Visual Function Associated with Blue Cone Ablation in Zebrafish by Gordon F. Hagerman (3366290)

“…This visually mediated behaviour decreased to about 5% or 20% of control levels following ablation of UV or blue cones, respectively (P<0.05). …”

Table_3_Mutations identified in engineered Escherichia coli with a reduced genome.XLSX by Yuto Kotaka (15907688)

“…Interestingly, a SNV was identified in the promoter region of hcaT in all five strains, which increased hcaT expression and, we predict, rescued the attenuated Δ37b growth. …”